SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens) 		5 / 10 VAL A 138
ALA A 166
ILE A 165
LEU A 216
PHE A 163
 None
 1.23A 3fl9A-5eh1A:
undetectable		 3fl9A-5eh1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens) 		5 / 9 ASP A 200
LEU A 202
THR A 237
ILE A 156
LEU A 155
 None
 1.07A 3hy7B-5eh1A:
undetectable		 3hy7B-5eh1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens) 		5 / 9 TYR A  69
VAL A 111
LEU A  40
GLN A  45
VAL A  84
 None
None
None
None
GOL  A 306 (-4.2A)
 1.20A 3jwqA-5eh1A:
undetectable		 3jwqA-5eh1A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens) 		4 / 6 ILE A  38
LEU A 113
PHE A 105
GLY A 104
 None
 1.05A 3sj1X-5eh1A:
undetectable		 3sj1X-5eh1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens) 		5 / 12 TYR A 235
ASN A 231
VAL A 148
ILE A 157
LEU A 199
 None
 1.37A 4k36A-5eh1A:
undetectable		 4k36A-5eh1A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens) 		4 / 6 PHE A 132
VAL A 111
TYR A  69
ILE A  82
 None
 1.06A 5iwuA-5eh1A:
undetectable		 5iwuA-5eh1A:
19.88