SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ei0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 12 GLY A 135
SER A  78
HIS A 354
LEU A 138
LEU A 192
 None
 1.08A 1fm6D-5ei0A:
undetectable		 1fm6D-5ei0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 GLN A 288
ASP A  54
LEU A 393
SER A 293
 None
 1.19A 1ig3A-5ei0A:
undetectable
1ig3B-5ei0A:
undetectable		 1ig3A-5ei0A:
23.50
1ig3B-5ei0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 10 ILE A 134
ILE A 119
ASN A  52
LEU A  77
ILE A 394
 None
 1.21A 2nnhB-5ei0A:
undetectable		 2nnhB-5ei0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 12 LEU A 358
LEU A  74
LEU A  60
THR A 365
PHE A 210
 None
 1.48A 2oaxA-5ei0A:
undetectable		 2oaxA-5ei0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 5 VAL A 249
TYR A 247
VAL A 306
ASP A 305
 None
 1.03A 2x45A-5ei0A:
undetectable		 2x45A-5ei0A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 5 VAL A 249
TYR A 247
VAL A 306
ASP A 305
 None
 1.09A 2x45C-5ei0A:
undetectable		 2x45C-5ei0A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 8 GLY A 135
VAL A 353
SER A 133
THR A 185
 None
 0.92A 2yoeB-5ei0A:
undetectable
2yoeC-5ei0A:
undetectable		 2yoeB-5ei0A:
20.81
2yoeC-5ei0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 ILE A 262
PHE A 272
ARG A 310
MET A 360
 None
 1.19A 2zxwN-5ei0A:
undetectable
2zxwW-5ei0A:
undetectable		 2zxwN-5ei0A:
21.11
2zxwW-5ei0A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 ILE A 341
PHE A  83
PHE A 332
GLY A 336
 None
 1.09A 3em0B-5ei0A:
1.1		 3em0B-5ei0A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 8 GLY A 327
PHE A 116
PHE A 102
PHE A 104
 None
 0.91A 3ko0B-5ei0A:
undetectable
3ko0J-5ei0A:
undetectable		 3ko0B-5ei0A:
13.45
3ko0J-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 8 GLY A 327
PHE A 116
PHE A 102
PHE A 104
 None
 0.83A 3ko0D-5ei0A:
undetectable
3ko0E-5ei0A:
undetectable		 3ko0D-5ei0A:
13.45
3ko0E-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 8 PHE A 102
PHE A 104
GLY A 327
PHE A 116
 None
 0.83A 3ko0B-5ei0A:
undetectable
3ko0J-5ei0A:
undetectable		 3ko0B-5ei0A:
13.45
3ko0J-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 8 GLY A 327
PHE A 116
PHE A 102
PHE A 104
 None
 0.90A 3ko0K-5ei0A:
undetectable
3ko0S-5ei0A:
undetectable		 3ko0K-5ei0A:
13.45
3ko0S-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 GLY A 327
PHE A 116
PHE A 102
PHE A 104
 None
 0.90A 3ko0L-5ei0A:
undetectable
3ko0N-5ei0A:
undetectable		 3ko0L-5ei0A:
13.45
3ko0N-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 8 GLY A 327
PHE A 116
PHE A 102
PHE A 104
 None
 0.81A 3ko0O-5ei0A:
undetectable
3ko0Q-5ei0A:
undetectable		 3ko0O-5ei0A:
13.45
3ko0Q-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 PHE A 102
PHE A 104
GLY A 327
PHE A 116
 None
 0.84A 3ko0K-5ei0A:
undetectable
3ko0S-5ei0A:
undetectable		 3ko0K-5ei0A:
13.45
3ko0S-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 PHE A 102
PHE A 104
GLY A 327
PHE A 116
 None
 0.92A 3ko0R-5ei0A:
undetectable
3ko0T-5ei0A:
undetectable		 3ko0R-5ei0A:
13.45
3ko0T-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 12 VAL A 384
LEU A 299
THR A 258
ILE A 259
GLU A 261
 None
 0.99A 3mdvB-5ei0A:
undetectable		 3mdvB-5ei0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 5 LEU A  74
ALA A 356
PHE A 404
ASN A 206
 None
 1.48A 3uq6A-5ei0A:
undetectable		 3uq6A-5ei0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 12 ILE A 408
ALA A 356
PHE A  73
ILE A 394
PHE A 209
 None
 1.01A 3w67C-5ei0A:
undetectable		 3w67C-5ei0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 6 LYS A 155
LEU A 151
ALA A 160
THR A 137
 None
 1.25A 4d7bB-5ei0A:
undetectable		 4d7bB-5ei0A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 12 MET A 202
LEU A 138
ALA A  82
LEU A  86
LEU A  88
 None
 1.02A 4m11B-5ei0A:
undetectable		 4m11B-5ei0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5ei0 SERPIN A12
(Homo
sapiens) 		6 / 12 LEU A 393
LEU A 405
GLY A 406
LEU A 311
ILE A 386
VAL A 308
 None
 1.43A 4ok1A-5ei0A:
undetectable		 4ok1A-5ei0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 7 PHE A 272
LEU A 260
THR A 365
VAL A 308
 None
 0.61A 4wnvD-5ei0A:
undetectable		 4wnvD-5ei0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5ei0 SERPIN A12
(Homo
sapiens) 		5 / 12 GLY A  89
ALA A  90
ILE A 331
THR A  94
VAL A 328
 None
 1.00A 4xdrA-5ei0A:
undetectable		 4xdrA-5ei0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5ei0 SERPIN A12
(Homo
sapiens) 		3 / 4 ARG A 363
GLY A 364
GLU A 217
 None
 0.47A 4z2dB-5ei0A:
undetectable
4z2dC-5ei0A:
undetectable		 4z2dB-5ei0A:
21.75
4z2dC-5ei0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 6 LYS A 155
LEU A 151
ALA A 160
THR A 137
 None
 1.17A 5l4iB-5ei0A:
undetectable		 5l4iB-5ei0A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5ei0 SERPIN A12
(Homo
sapiens) 		4 / 6 ILE A 386
TYR A 390
LEU A 392
VAL A 308
 None
 1.16A 6f6jA-5ei0A:
undetectable		 6f6jA-5ei0A:
undetectable