SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ei3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		5 / 12 PRO A  87
GLY A  88
ASN A  50
LYS A  49
LEU A  81
 None
 1.41A 2b9eA-5ei3A:
undetectable		 2b9eA-5ei3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		3 / 3 GLN A 198
THR A 205
TRP A 102
 None
None
5O8  A 301 (-4.4A)
 1.14A 2rctA-5ei3A:
undetectable		 2rctA-5ei3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		5 / 10 GLU A 132
GLY A 180
VAL A 176
ALA A 175
PHE A 142
 None
 1.12A 3a3yA-5ei3A:
undetectable		 3a3yA-5ei3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		5 / 10 GLU A 132
GLY A 180
VAL A 176
PHE A 142
THR A 167
 None
 1.07A 3a3yA-5ei3A:
undetectable		 3a3yA-5ei3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.25A 3sudA-5ei3A:
1.1		 3sudA-5ei3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 5 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.24A 3sueC-5ei3A:
0.6		 3sueC-5ei3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		3 / 3 ASN A  41
TRP A  43
ASP A 147
 None
 1.27A 4a7tA-5ei3A:
undetectable
4a7tF-5ei3A:
undetectable		 4a7tA-5ei3A:
22.27
4a7tF-5ei3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 8 ASN A 213
GLY A 196
VAL A 216
ILE A 193
 None
 0.88A 4fglD-5ei3A:
undetectable		 4fglD-5ei3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 8 ILE A 115
ILE A 163
ALA A 152
TRP A 113
 None
 0.99A 4ou1A-5ei3A:
undetectable		 4ou1A-5ei3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		3 / 3 LYS A 162
LEU A 114
ARG A 112
 SO4  A 302 ( 3.9A)
None
5O8  A 301 (-3.5A)
 0.92A 5yw0A-5ei3A:
undetectable		 5yw0A-5ei3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 6 TYR A  91
HIS A  78
ASN A  77
TYR A  76
 None
 1.33A 6gneA-5ei3A:
undetectable		 6gneA-5ei3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Homo
sapiens) 		4 / 8 TYR A  91
HIS A  78
ASN A  77
TYR A  76
 None
 1.32A 6gneB-5ei3A:
undetectable		 6gneB-5ei3A:
17.62