SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eil'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5eil TRI-05
(synthetic
construct) 		4 / 7 ASP A 101
SER A 131
LEU A 141
GLU A 144
 None
 1.10A 2cdqB-5eilA:
undetectable		 2cdqB-5eilA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5eil TRI-05
(synthetic
construct) 		5 / 12 VAL A  19
LEU A   7
LEU A  40
ILE A  51
ALA A  60
 None
 1.02A 4p65B-5eilA:
undetectable
4p65D-5eilA:
undetectable
4p65I-5eilA:
undetectable
4p65J-5eilA:
undetectable		 4p65B-5eilA:
11.45
4p65D-5eilA:
11.45
4p65I-5eilA:
6.94
4p65J-5eilA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5eil TRI-05
(synthetic
construct) 		5 / 12 VAL A  85
LEU A  73
LEU A 106
ILE A 117
ALA A 126
 None
 1.01A 4p65B-5eilA:
undetectable
4p65D-5eilA:
undetectable
4p65I-5eilA:
undetectable
4p65J-5eilA:
undetectable		 4p65B-5eilA:
11.45
4p65D-5eilA:
11.45
4p65I-5eilA:
6.94
4p65J-5eilA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5eil TRI-05
(synthetic
construct) 		5 / 12 LEU A 106
VAL A  85
LEU A  73
ILE A 117
ALA A 126
 None
 1.02A 4p65F-5eilA:
undetectable
4p65H-5eilA:
undetectable
4p65K-5eilA:
undetectable
4p65L-5eilA:
undetectable		 4p65F-5eilA:
11.45
4p65H-5eilA:
11.45
4p65K-5eilA:
6.94
4p65L-5eilA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5eil TRI-05
(synthetic
construct) 		4 / 4 ASP A  68
SER A  67
ASP A  66
HIS A  41
 None
 1.33A 5wyqB-5eilA:
undetectable		 5wyqB-5eilA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5eil TRI-05
(synthetic
construct) 		4 / 4 ASP A 134
SER A 133
ASP A 132
HIS A 107
 None
 1.37A 5wyqB-5eilA:
undetectable		 5wyqB-5eilA:
25.00