SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 5 THR A 151
GLU A 212
HIS A  77
HIS A 207
 None
None
NAP  A 401 (-3.2A)
None
 1.48A 1d4fA-5eioA:
3.6		 1d4fA-5eioA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A 146
ALA A 150
ALA A 240
ILE A 293
ILE A 310
 None
 1.04A 1fk6A-5eioA:
undetectable		 1fk6A-5eioA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 GLU A 212
HIS A 209
ASP A 100
 None
 0.78A 1i9gA-5eioA:
3.6		 1i9gA-5eioA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 6 TYR A 261
GLU A 333
ILE A 310
GLY A 156
 None
 1.15A 1maaB-5eioA:
undetectable
1maaD-5eioA:
undetectable		 1maaB-5eioA:
22.42
1maaD-5eioA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 THR A 317
GLY A  10
GLY A  13
THR A  35
PRO A  76
 NAP  A 401 (-3.0A)
NAP  A 401 (-3.1A)
NAP  A 401 (-3.1A)
None
NAP  A 401 (-4.2A)
 0.98A 1nv8A-5eioA:
3.4		 1nv8A-5eioA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 GLY A 156
LEU A 217
ILE A 267
HIS A 320
ALA A 291
 None
 1.39A 2a58A-5eioA:
undetectable
2a58E-5eioA:
undetectable		 2a58A-5eioA:
20.85
2a58E-5eioA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 ILE A 267
HIS A 320
ALA A 291
GLY A 156
LEU A 217
 None
 1.38A 2a58C-5eioA:
undetectable
2a58D-5eioA:
undetectable		 2a58C-5eioA:
20.85
2a58D-5eioA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.20A 2f78A-5eioA:
undetectable		 2f78A-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.18A 2f78B-5eioA:
undetectable		 2f78B-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.27A 2f7aA-5eioA:
undetectable		 2f7aA-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.15A 2f7aB-5eioA:
undetectable		 2f7aB-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 ILE A 310
GLY A 147
HIS A 209
LEU A 175
GLY A 316
 None
NAP  A 401 ( 4.4A)
None
None
None
 1.32A 2fn1A-5eioA:
undetectable		 2fn1A-5eioA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 VAL A 213
LEU A 160
ILE A 236
VAL A 173
ILE A 171
 None
 1.12A 2uxoB-5eioA:
undetectable		 2uxoB-5eioA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 PRO A 106
PHE A 101
LYS A 104
 None
 1.24A 3bjwG-5eioA:
undetectable		 3bjwG-5eioA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 4 THR A 308
VAL A 285
GLY A 316
THR A 317
 None
None
None
NAP  A 401 (-3.0A)
 1.09A 3cflA-5eioA:
undetectable		 3cflA-5eioA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ILE A  60
GLY A  16
PHE A  19
LEU A   6
LEU A  57
 None
 1.18A 3em0B-5eioA:
undetectable		 3em0B-5eioA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 8 ASP A  85
CYH A 124
PHE A 101
ASP A 120
 None
 1.03A 3m0wE-5eioA:
undetectable
3m0wF-5eioA:
undetectable
3m0wG-5eioA:
undetectable
3m0wH-5eioA:
undetectable		 3m0wE-5eioA:
15.08
3m0wF-5eioA:
15.08
3m0wG-5eioA:
15.08
3m0wH-5eioA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 VAL A  31
LEU A   6
SER A   7
GLY A  16
ALA A  11
 None
 1.09A 3n8yA-5eioA:
undetectable		 3n8yA-5eioA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  75
GLU A  18
ALA A  15
ASP A  96
LEU A  97
 NAP  A 401 (-4.6A)
None
NAP  A 401 (-3.3A)
None
NAP  A 401 (-4.9A)
 1.24A 3ou6D-5eioA:
2.9		 3ou6D-5eioA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 5 GLU A 250
GLU A 296
PHE A 295
TYR A 279
 None
 1.43A 4a97J-5eioA:
undetectable		 4a97J-5eioA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  10
GLY A  13
LEU A  75
PRO A  76
VAL A  79
 NAP  A 401 (-3.1A)
NAP  A 401 (-3.1A)
NAP  A 401 (-4.6A)
NAP  A 401 (-4.2A)
NAP  A 401 (-4.6A)
 0.91A 4gc9A-5eioA:
3.1		 4gc9A-5eioA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 PRO A 332
ASN A 326
HIS A  26
 None
 1.00A 4ma3H-5eioA:
0.9
4ma3L-5eioA:
undetectable		 4ma3H-5eioA:
19.54
4ma3L-5eioA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  97
GLY A 316
CYH A 148
ASN A 149
ALA A 291
 NAP  A 401 (-4.9A)
None
NAP  A 401 ( 3.7A)
None
None
 1.34A 4pclB-5eioA:
undetectable		 4pclB-5eioA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 VAL A  31
LEU A   6
SER A   7
GLY A  16
ALA A  11
 None
 1.10A 4rrwB-5eioA:
undetectable		 4rrwB-5eioA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 VAL A  31
LEU A   6
SER A   7
GLY A  16
ALA A  11
 None
 1.10A 4rrzB-5eioA:
undetectable		 4rrzB-5eioA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 7 GLU A  63
LEU A  65
LEU A  90
LEU A  71
 None
 0.66A 4wg0B-5eioA:
undetectable
4wg0C-5eioA:
undetectable		 4wg0B-5eioA:
3.54
4wg0C-5eioA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 7 LEU A  90
LEU A  71
GLU A  63
LEU A  65
 None
 0.74A 4wg0L-5eioA:
undetectable
4wg0M-5eioA:
undetectable		 4wg0L-5eioA:
3.54
4wg0M-5eioA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 ALA A 128
VAL A  72
GLY A 319
PHE A  19
GLY A  16
 None
 1.14A 4xp4A-5eioA:
undetectable		 4xp4A-5eioA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 GLU A 212
HIS A 209
ASP A 100
 None
 0.81A 5c0oG-5eioA:
3.2		 5c0oG-5eioA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		4 / 7 VAL A 173
LEU A 175
ALA A 240
LEU A 217
 None
 0.54A 5jq7A-5eioA:
undetectable		 5jq7A-5eioA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A 264
GLU A 131
VAL A 129
GLN A 323
THR A 334
 None
 1.45A 6cdqB-5eioA:
undetectable		 6cdqB-5eioA:
12.93