SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		4 / 6 LEU A1420
ILE A1386
VAL A1389
ALA A1382
 None
 0.93A 2j5mA-5eixA:
undetectable		 2j5mA-5eixA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		4 / 7 GLU A1464
ARG A1361
GLU A1135
SER A1134
 None
 1.23A 2zt7A-5eixA:
undetectable		 2zt7A-5eixA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		3 / 3 GLU A 544
GLY A 547
THR A 546
 None
 0.57A 3iazA-5eixA:
1.9		 3iazA-5eixA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		5 / 12 GLY A1168
TYR A1097
LEU A1131
VAL A1188
ALA A1189
 None
 1.17A 3t7vA-5eixA:
undetectable		 3t7vA-5eixA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		3 / 4 SER A 422
GLY A1078
GLU A1084
 None
None
MG  A1502 ( 4.3A)
 0.50A 4juoA-5eixA:
45.4
4juoC-5eixA:
24.5		 4juoA-5eixA:
29.96
4juoC-5eixA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		3 / 3 ARG A1354
ASP A1468
ARG A1361
 None
 0.79A 4mx0A-5eixA:
undetectable		 4mx0A-5eixA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
(Klebsiella
pneumoniae) 		3 / 3 VAL A1070
GLN A1042
CYH A1082
 None
 0.84A 5icxA-5eixA:
undetectable
5icxE-5eixA:
undetectable		 5icxA-5eixA:
14.19
5icxE-5eixA:
3.49