SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ej3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		5 / 12 SER A 138
LEU A 165
ILE A 116
ALA A 157
ARG A  59
 None
 1.28A 2v0mC-5ej3A:
undetectable		 2v0mC-5ej3A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 8 HIS A 154
SER A 138
ASP A  92
ARG A 144
 None
 1.09A 2v57A-5ej3A:
undetectable		 2v57A-5ej3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 8 HIS A 154
SER A 138
ASP A  92
ARG A 144
 None
 1.09A 2v57C-5ej3A:
undetectable		 2v57C-5ej3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 6 VAL A  48
ASN A   7
TYR A  78
GLU A  87
 None
 1.23A 3q5sA-5ej3A:
undetectable		 3q5sA-5ej3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		5 / 12 GLY A  10
ILE A 187
GLY A  52
ALA A  49
SER A 185
 None
 1.11A 3sudB-5ej3A:
undetectable		 3sudB-5ej3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		5 / 11 VAL A 189
TYR A  37
SER A 185
SER A 186
GLY A  65
 None
 1.20A 4mmaA-5ej3A:
undetectable		 4mmaA-5ej3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 7 TYR A  74
TYR A  37
GLU A 177
PHE A  67
 None
 1.14A 5aclA-5ej3A:
undetectable		 5aclA-5ej3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 8 SER A 169
TYR A  88
ASN A 167
SER A 126
 None
 1.11A 5l1fA-5ej3A:
undetectable
5l1fB-5ej3A:
undetectable		 5l1fA-5ej3A:
15.35
5l1fB-5ej3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		3 / 3 GLY A  32
THR A   2
ASN A  12
 None
 0.65A 5odiG-5ej3A:
undetectable		 5odiG-5ej3A:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 8 THR A 100
THR A 119
ARG A 121
GLN A 135
 None
 1.26A 5tzoA-5ej3A:
27.5		 5tzoA-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		5 / 8 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.74A 5tzoA-5ej3A:
27.5		 5tzoA-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
PRO A 125
TRP A 137
TYR A 171
 None
 0.75A 5tzoA-5ej3A:
27.5		 5tzoA-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.81A 5tzoA-5ej3A:
27.5		 5tzoA-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.79A 5tzoB-5ej3A:
27.5		 5tzoB-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		5 / 8 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.73A 5tzoB-5ej3A:
27.5		 5tzoB-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
PRO A 125
TRP A 137
TYR A 171
 None
 0.78A 5tzoC-5ej3A:
27.5		 5tzoC-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.88A 5tzoC-5ej3A:
27.5		 5tzoC-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		5 / 8 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.70A 5tzoC-5ej3A:
27.5		 5tzoC-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 5 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.88A 6jmjA-5ej3A:
undetectable		 6jmjA-5ej3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 7 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.86A 6jnhA-5ej3A:
undetectable		 6jnhA-5ej3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5ej3 ENDO-1,4-BETA-XYLANA
SE B
(Streptomyces
lividans) 		4 / 6 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.87A 6jogA-5ej3A:
undetectable		 6jogA-5ej3A:
19.56