SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ejs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 SER A1919
GLU A1956
LEU A1856
TRP A1859
 None
 1.40A 1agmA-5ejsA:
undetectable		 1agmA-5ejsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		3 / 3 ASP A1955
LEU A1995
LEU A1994
 None
 0.71A 1ikeA-5ejsA:
undetectable		 1ikeA-5ejsA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 9 ILE A2260
GLY A2264
TYR A2186
ILE A2177
GLU A2180
 None
 1.30A 1mrgA-5ejsA:
undetectable		 1mrgA-5ejsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		3 / 3 ASP A1955
LEU A1995
LEU A1994
 None
 0.71A 1np1B-5ejsA:
undetectable		 1np1B-5ejsA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 4 SER A2099
ILE A2100
VAL A2144
THR A2273
 None
 1.25A 1u70A-5ejsA:
undetectable		 1u70A-5ejsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 10 PHE A2142
VAL A2089
ILE A2082
THR A2080
ILE A2076
 None
 1.11A 1z11C-5ejsA:
undetectable		 1z11C-5ejsA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 10 PHE A2142
VAL A2089
ILE A2082
THR A2080
ILE A2076
 None
 1.11A 1z11D-5ejsA:
undetectable		 1z11D-5ejsA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 ILE A1944
PHE A2050
GLU A2046
SER A2029
SER A1985
 None
 1.29A 3apwA-5ejsA:
undetectable		 3apwA-5ejsA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 11 LEU A2269
ASN A2291
PHE A2275
TRP A2287
LEU A2274
 None
 1.31A 3bgrA-5ejsA:
undetectable
3bgrB-5ejsA:
1.1		 3bgrA-5ejsA:
21.96
3bgrB-5ejsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 LEU A2269
ASN A2291
PHE A2275
TRP A2287
LEU A2274
 None
 1.31A 3medA-5ejsA:
undetectable
3medB-5ejsA:
undetectable		 3medA-5ejsA:
21.48
3medB-5ejsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 VAL A2222
LEU A2223
ILE A2240
ALA A2199
 None
 0.99A 3n8yB-5ejsA:
undetectable		 3n8yB-5ejsA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 ILE A2290
VAL A2295
ILE A2277
THR A2328
ILE A2347
 None
 1.27A 3vrjA-5ejsA:
undetectable
3vrjC-5ejsA:
undetectable		 3vrjA-5ejsA:
19.32
3vrjC-5ejsA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 9 ILE A2260
GLY A2264
TYR A2186
ILE A2177
GLU A2180
 None
 1.33A 4yp2B-5ejsA:
undetectable		 4yp2B-5ejsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 PRO A2042
ILE A1957
LEU A1953
PHE A1988
THR A1987
 None
 1.12A 5bykA-5ejsA:
undetectable		 5bykA-5ejsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 9 ILE A2260
GLY A2264
TYR A2186
ILE A2177
GLU A2180
 None
 1.33A 5cf9B-5ejsA:
undetectable		 5cf9B-5ejsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5ejs MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 6 LEU A2262
LEU A2204
LEU A2201
LEU A2247
 None
 0.92A 5gs4A-5ejsA:
undetectable		 5gs4A-5ejsA:
18.40