SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ejy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 GLN A 354
GLY A 280
ASN A 279
LEU A 527
PHE A 331
 None
 0.96A 1bx4A-5ejyA:
undetectable		 1bx4A-5ejyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 7 LEU A 468
GLY A 472
LEU A 535
TYR A 531
 None
 1.06A 1gtiD-5ejyA:
undetectable		 1gtiD-5ejyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 LEU A 300
ASP A 293
LEU A 330
SER A 276
ILE A 284
 None
 1.31A 1uobA-5ejyA:
undetectable		 1uobA-5ejyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 7 SER A 276
SER A 263
SER A 267
ASN A 279
 None
 0.97A 2cmlA-5ejyA:
undetectable		 2cmlA-5ejyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 8 SER A 276
SER A 263
SER A 267
ASN A 279
 None
 1.07A 2cmlB-5ejyA:
undetectable		 2cmlB-5ejyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 8 SER A 276
SER A 263
SER A 267
ASN A 279
 None
 0.98A 2cmlC-5ejyA:
undetectable		 2cmlC-5ejyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 8 SER A 276
SER A 263
SER A 267
ASN A 279
 None
 0.99A 2cmlD-5ejyA:
undetectable		 2cmlD-5ejyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 6 PHE A  99
GLN A 144
LEU A  65
LEU A  83
 None
 1.15A 3bgdA-5ejyA:
undetectable		 3bgdA-5ejyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 6 GLN A 380
TYR A 419
ILE A 416
SER A 383
 None
 1.13A 3peoG-5ejyA:
undetectable		 3peoG-5ejyA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 4 LYS A 327
PHE A 326
PHE A 324
VAL A 303
 None
 1.24A 3rv5A-5ejyA:
0.3
3rv5B-5ejyA:
0.2		 3rv5A-5ejyA:
10.73
3rv5B-5ejyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 6 HIS A  78
SER A 100
GLU A 140
ASP A  88
 None
15P  A 602 ( 4.3A)
None
None
 1.32A 4blvA-5ejyA:
undetectable		 4blvA-5ejyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.05A 4coxA-5ejyA:
undetectable		 4coxA-5ejyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.03A 4coxB-5ejyA:
undetectable		 4coxB-5ejyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.04A 4coxC-5ejyA:
undetectable		 4coxC-5ejyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.05A 4coxD-5ejyA:
undetectable		 4coxD-5ejyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 LEU A  83
ILE A  62
ALA A  56
PHE A  72
 None
 0.86A 4dc3B-5ejyA:
undetectable		 4dc3B-5ejyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 10 LEU A 466
LEU A 524
ALA A 516
LEU A 497
LEU A 514
 None
 1.24A 4p65A-5ejyA:
undetectable
4p65B-5ejyA:
undetectable
4p65F-5ejyA:
undetectable
4p65H-5ejyA:
undetectable		 4p65A-5ejyA:
7.26
4p65B-5ejyA:
4.74
4p65F-5ejyA:
4.74
4p65H-5ejyA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 11 LEU A 514
LEU A 497
LEU A 466
LEU A 524
ALA A 516
 None
 1.08A 4p65B-5ejyA:
undetectable
4p65D-5ejyA:
undetectable
4p65G-5ejyA:
undetectable
4p65H-5ejyA:
undetectable		 4p65B-5ejyA:
4.74
4p65D-5ejyA:
4.74
4p65G-5ejyA:
7.26
4p65H-5ejyA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.10A 4rrwA-5ejyA:
undetectable		 4rrwA-5ejyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.09A 4rrwB-5ejyA:
undetectable		 4rrwB-5ejyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.08A 4rrwC-5ejyA:
undetectable		 4rrwC-5ejyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.10A 4rrzA-5ejyA:
undetectable		 4rrzA-5ejyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.09A 4rrzB-5ejyA:
undetectable		 4rrzB-5ejyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.08A 4rrzC-5ejyA:
undetectable		 4rrzC-5ejyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 PHE A 182
LEU A 210
GLY A 131
LEU A 132
VAL A 222
 None
 1.03A 4wnwA-5ejyA:
undetectable		 4wnwA-5ejyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 ILE A 141
VAL A 222
LEU A 137
PHE A 172
THR A 171
 None
 1.24A 5bykA-5ejyA:
undetectable		 5bykA-5ejyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		3 / 3 THR A 258
ASP A 254
GLU A 227
 None
 0.83A 5fa8A-5ejyA:
undetectable		 5fa8A-5ejyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.13A 5ikrA-5ejyA:
undetectable		 5ikrA-5ejyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		5 / 12 SER A 149
VAL A 199
ALA A 203
SER A 206
LEU A 186
 None
 1.03A 5kirB-5ejyA:
undetectable		 5kirB-5ejyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 4 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.33A 5n0rA-5ejyA:
undetectable		 5n0rA-5ejyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 4 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.32A 5n0sA-5ejyA:
undetectable		 5n0sA-5ejyA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.30A 5n0tA-5ejyA:
undetectable		 5n0tA-5ejyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 4 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.34A 5n0wA-5ejyA:
undetectable		 5n0wA-5ejyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.38A 5n0wB-5ejyA:
undetectable		 5n0wB-5ejyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 4 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.38A 5n0xA-5ejyA:
undetectable		 5n0xA-5ejyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 SER A 206
ALA A 203
GLN A 191
THR A 189
 None
 1.39A 5n4iA-5ejyA:
undetectable		 5n4iA-5ejyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 7 SER A 305
ILE A 253
ASP A 302
ASN A 216
 None
 1.01A 5n5dA-5ejyA:
undetectable		 5n5dA-5ejyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 5 GLU A 349
PHE A 350
ASP A 245
HIS A 353
 None
 1.16A 6b58C-5ejyA:
0.0		 6b58C-5ejyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		3 / 3 LYS A 232
SER A 202
SER A 198
 None
 0.97A 6gbfA-5ejyA:
undetectable		 6gbfA-5ejyA:
21.35