SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ek0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Homo
sapiens;
Arcobacter
butzleri) 		5 / 12 THR A1672
LEU A1690
GLY A1656
GLY A1664
ALA A1651
 None
 1.21A 1httC-5ek0A:
undetectable		 1httC-5ek0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Homo
sapiens;
Arcobacter
butzleri) 		5 / 12 THR A1672
LEU A1690
GLY A1656
GLY A1664
ALA A1651
 None
 1.24A 1httD-5ek0A:
undetectable		 1httD-5ek0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Arcobacter
butzleri;
Homo
sapiens) 		4 / 6 ARG A1559
PHE A1562
ILE A1555
PHE A1572
 None
 1.20A 2qeiA-5ek0A:
undetectable		 2qeiA-5ek0A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Arcobacter
butzleri;
Homo
sapiens) 		5 / 11 ALA A1615
PHE A1570
SER A1578
ILE A1577
LEU A1610
 None
 1.08A 3qg2B-5ek0A:
undetectable		 3qg2B-5ek0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Arcobacter
butzleri;
Homo
sapiens) 		4 / 8 LEU A1612
THR A1614
LEU A1610
VAL A1623
 None
 0.93A 4qknA-5ek0A:
2.6		 4qknA-5ek0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Homo
sapiens;
Arcobacter
butzleri) 		4 / 6 ALA A1615
THR A1614
VAL A1613
VAL A1574
 None
 1.06A 5eckA-5ek0A:
undetectable		 5eckA-5ek0A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Homo
sapiens;
Arcobacter
butzleri) 		4 / 6 PHE A1704
PRO A1703
THR A1709
ILE A1705
 None
 1.29A 5ih0A-5ek0A:
undetectable		 5ih0A-5ek0A:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Arcobacter
butzleri;
Homo
sapiens) 		4 / 6 THR A1665
GLY A1667
GLU A1668
PHE A1670
 PX4  A1802 (-4.2A)
PX4  A1802 (-3.3A)
PX4  A1802 (-3.5A)
PX4  A1802 (-4.4A)
 0.87A 5kmfA-5ek0A:
19.4
5kmfC-5ek0A:
19.7		 5kmfA-5ek0A:
81.40
5kmfC-5ek0A:
81.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Homo
sapiens;
Arcobacter
butzleri) 		4 / 6 MET A1677
THR A1678
LEU A1679
MET A1712
 PX4  A1806 ( 4.3A)
PX4  A1806 ( 4.8A)
None
PX4  A1806 ( 4.6A)
 0.66A 6mvxA-5ek0A:
18.7
6mvxB-5ek0A:
18.8
6mvxC-5ek0A:
18.9		 6mvxA-5ek0A:
82.39
6mvxB-5ek0A:
82.39
6mvxC-5ek0A:
82.39