SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ek8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 ASP A 575
HIS A 359
ILE A 397
HIS A 570
 None
FE2  A 701 (-3.5A)
None
FE2  A 701 (-3.6A)
 0.97A 1ei6C-5ek8A:
undetectable		 1ei6C-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ARG A 173
GLY A 401
ASP A 402
 None
 0.56A 1kf6A-5ek8A:
undetectable
1kf6B-5ek8A:
undetectable		 1kf6A-5ek8A:
21.19
1kf6B-5ek8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 ARG A  78
GLY A 145
ASP A 146
TYR A 153
 None
 1.35A 1kf6M-5ek8A:
undetectable
1kf6N-5ek8A:
undetectable		 1kf6M-5ek8A:
21.19
1kf6N-5ek8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.72A 1rjoA-5ek8A:
undetectable		 1rjoA-5ek8A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.69A 1rkyA-5ek8A:
undetectable		 1rkyA-5ek8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.76A 1v54A-5ek8A:
1.6		 1v54A-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.76A 1v54N-5ek8A:
undetectable		 1v54N-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.73A 1v55A-5ek8A:
1.5		 1v55A-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.75A 1v55N-5ek8A:
undetectable		 1v55N-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.71A 1w2zD-5ek8A:
undetectable		 1w2zD-5ek8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 PHE A  98
ARG A 487
ASN A  95
 None
 0.91A 1xzxX-5ek8A:
undetectable		 1xzxX-5ek8A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 SER A 313
SER A 588
GLN A 614
ASP A 289
 None
 1.36A 2cl5B-5ek8A:
undetectable		 2cl5B-5ek8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.76A 2dyrN-5ek8A:
undetectable		 2dyrN-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.72A 2eijA-5ek8A:
undetectable		 2eijA-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.75A 2eijN-5ek8A:
undetectable		 2eijN-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.71A 2eikA-5ek8A:
undetectable		 2eikA-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.72A 2eimN-5ek8A:
undetectable		 2eimN-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 5 LEU A 458
ALA A 456
TRP A 572
LEU A 568
 None
 1.22A 2oaxA-5ek8A:
undetectable		 2oaxA-5ek8A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.73A 2oqeC-5ek8A:
undetectable		 2oqeC-5ek8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.73A 2oqeF-5ek8A:
undetectable		 2oqeF-5ek8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.68A 2w0qA-5ek8A:
undetectable		 2w0qA-5ek8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.69A 2w0qB-5ek8A:
undetectable		 2w0qB-5ek8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 SER A 313
SER A 588
GLN A 614
ASP A 289
 None
 1.37A 2zvjA-5ek8A:
undetectable		 2zvjA-5ek8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 ALA A 206
GLU A  11
LEU A 404
TYR A 228
THR A 209
 None
 1.20A 2zzaA-5ek8A:
undetectable		 2zzaA-5ek8A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 11 ALA A 206
GLU A  11
LEU A 404
TYR A 228
THR A 209
 None
 1.18A 2zzaB-5ek8A:
undetectable		 2zzaB-5ek8A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ARG A 487
ASP A 551
ASN A 545
 None
 0.82A 2zzmA-5ek8A:
undetectable		 2zzmA-5ek8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.73A 3ag1A-5ek8A:
undetectable		 3ag1A-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.75A 3ag2N-5ek8A:
undetectable		 3ag2N-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.75A 3ag3A-5ek8A:
undetectable		 3ag3A-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.66A 3ag4A-5ek8A:
3.4		 3ag4A-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.71A 3ag4N-5ek8A:
undetectable		 3ag4N-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.73A 3hiiA-5ek8A:
undetectable		 3hiiA-5ek8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.71A 3hiiB-5ek8A:
undetectable		 3hiiB-5ek8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 9 HIS A 570
HIS A 359
HIS A 364
ILE A 394
LEU A 665
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
None
None
 1.30A 3hy7A-5ek8A:
undetectable		 3hy7A-5ek8A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 LYS A 191
ILE A 174
PHE A 175
 None
 0.97A 3j7zS-5ek8A:
2.1
3j7za-5ek8A:
undetectable		 3j7zS-5ek8A:
11.15
3j7za-5ek8A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 10 PRO A 104
GLY A  88
TYR A 102
GLY A 108
ALA A 107
 None
 1.48A 3pp7B-5ek8A:
undetectable		 3pp7B-5ek8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 ASP A 448
ASP A 449
VAL A 251
LEU A 299
 None
 0.99A 4f8hA-5ek8A:
2.5
4f8hB-5ek8A:
2.4		 4f8hA-5ek8A:
20.26
4f8hB-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 ASP A 448
ASP A 449
VAL A 251
LEU A 299
 None
 1.03A 4f8hB-5ek8A:
2.4
4f8hC-5ek8A:
2.4		 4f8hB-5ek8A:
20.26
4f8hC-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 ASP A 448
ASP A 449
VAL A 251
LEU A 299
 None
 1.01A 4f8hC-5ek8A:
2.4
4f8hD-5ek8A:
2.4		 4f8hC-5ek8A:
20.26
4f8hD-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 ASP A 448
ASP A 449
VAL A 251
LEU A 299
 None
 0.99A 4f8hD-5ek8A:
2.4
4f8hE-5ek8A:
2.4		 4f8hD-5ek8A:
20.26
4f8hE-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 VAL A 251
LEU A 299
ASP A 448
ASP A 449
 None
 1.00A 4f8hA-5ek8A:
2.4
4f8hE-5ek8A:
2.5		 4f8hA-5ek8A:
20.26
4f8hE-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 11 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.91A 4j6cA-5ek8A:
undetectable		 4j6cA-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 10 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.90A 4j6cB-5ek8A:
undetectable		 4j6cB-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.89A 4j6dA-5ek8A:
undetectable		 4j6dA-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.89A 4j6dB-5ek8A:
undetectable		 4j6dB-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.88A 4jbtA-5ek8A:
0.5		 4jbtA-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 11 GLN A 193
ALA A 194
ALA A 198
THR A 202
LEU A 404
 None
 0.89A 4jbtB-5ek8A:
undetectable		 4jbtB-5ek8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 4 ILE A 624
SER A 197
ASP A 575
ASP A 658
 None
 1.26A 4krhB-5ek8A:
undetectable		 4krhB-5ek8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ILE A 394
MET A 176
ARG A 399
 None
 0.92A 4lnwA-5ek8A:
undetectable		 4lnwA-5ek8A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ILE A 394
MET A 176
ARG A 399
 None
 0.92A 4lnxA-5ek8A:
undetectable		 4lnxA-5ek8A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 5 VAL A 483
TYR A 466
ILE A 462
THR A 566
 None
 1.33A 4ze1A-5ek8A:
0.0		 4ze1A-5ek8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.71A 5b1bA-5ek8A:
0.4		 5b1bA-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.73A 5b1bN-5ek8A:
undetectable		 5b1bN-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.73A 5b3sA-5ek8A:
undetectable		 5b3sA-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.74A 5b3sN-5ek8A:
undetectable		 5b3sN-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 ILE A 204
ALA A 611
THR A 612
VAL A 615
 None
 0.66A 5eclD-5ek8A:
1.9		 5eclD-5ek8A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 5 SER A 313
SER A 588
GLN A 614
ASP A 289
 None
 1.36A 5fhrB-5ek8A:
undetectable		 5fhrB-5ek8A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ARG A 245
THR A 233
ASP A 237
 None
 0.84A 5g5gA-5ek8A:
undetectable
5g5gB-5ek8A:
undetectable		 5g5gA-5ek8A:
14.80
5g5gB-5ek8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 TYR A 516
LEU A 255
LEU A 304
THR A 307
 None
 1.10A 5hs6A-5ek8A:
undetectable		 5hs6A-5ek8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 5 ALA A 295
VAL A 293
PHE A 250
ILE A 345
 None
 0.81A 5of1A-5ek8A:
undetectable		 5of1A-5ek8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 5 ALA A 295
VAL A 293
PHE A 250
ILE A 345
 None
 0.81A 5of1B-5ek8A:
undetectable		 5of1B-5ek8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 495
SER A 496
LYS A 536
 None
 1.20A 5os7A-5ek8A:
undetectable		 5os7A-5ek8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.70A 5x19A-5ek8A:
undetectable		 5x19A-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.71A 5x1bA-5ek8A:
2.5		 5x1bA-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 570
HIS A 364
HIS A 359
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
 0.71A 5x1fA-5ek8A:
undetectable		 5x1fA-5ek8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5ek8 LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 495
SER A 496
LYS A 536
 None
 1.20A 6gmdB-5ek8A:
undetectable		 6gmdB-5ek8A:
19.09