SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 THR A 129
LEU A 177
GLY A 180
LEU A 262
 NAD  A 400 (-2.7A)
None
None
None
 0.99A 1gtiD-5eksA:
undetectable		 1gtiD-5eksA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 ASP A  22
HIS A  51
ASP A 165
 None
 0.77A 1nw5A-5eksA:
3.3		 1nw5A-5eksA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 PRO A 306
GLY A 249
LEU A 256
PRO A 302
 None
 0.92A 1ya4B-5eksA:
undetectable		 1ya4B-5eksA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 ALA A 275
THR A 292
PHE A 248
 None
 0.54A 2c6nB-5eksA:
undetectable		 2c6nB-5eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A 192
LEU A 336
GLY A 337
ARG A 291
 None
 1.20A 2j2pA-5eksA:
undetectable
2j2pB-5eksA:
undetectable		 2j2pA-5eksA:
21.87
2j2pB-5eksA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 4 ASP A 192
LEU A 336
GLY A 337
ARG A 291
 None
 1.24A 2j2pD-5eksA:
undetectable
2j2pE-5eksA:
undetectable		 2j2pD-5eksA:
21.87
2j2pE-5eksA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		5 / 12 LEU A  27
PHE A 123
GLY A 107
VAL A   6
ILE A  15
 None
 1.06A 3c6gA-5eksA:
undetectable		 3c6gA-5eksA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 HIS A 246
SER A 254
GLU A 253
 MG  A 401 (-3.6A)
None
None
 0.87A 3s8pA-5eksA:
undetectable		 3s8pA-5eksA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 LEU A 336
ALA A 188
MET A 271
THR A 292
 None
 1.30A 3vasB-5eksA:
2.9		 3vasB-5eksA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 HIS A 263
GLU A  72
ASN A 151
 MG  A 401 (-3.3A)
NAD  A 400 (-3.0A)
NAD  A 400 (-3.4A)
 0.64A 4bupB-5eksA:
undetectable		 4bupB-5eksA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 THR A  97
LEU A  59
VAL A 161
VAL A 124
 None
 0.96A 4cp4A-5eksA:
undetectable		 4cp4A-5eksA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 228
ARG A 227
VAL A 331
MET A 271
 None
 1.30A 4f4dA-5eksA:
undetectable		 4f4dA-5eksA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		5 / 12 GLN A 168
VAL A 218
SER A 132
LEU A  21
LEU A 163
 None
None
NAD  A 400 ( 4.0A)
None
None
 1.26A 4qztA-5eksA:
undetectable		 4qztA-5eksA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 SER A 304
LEU A 189
MET A 271
 None
 0.82A 5ikrB-5eksA:
undetectable		 5ikrB-5eksA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 HIS A 263
GLU A  72
ASN A 151
 MG  A 401 (-3.3A)
NAD  A 400 (-3.0A)
NAD  A 400 (-3.4A)
 0.56A 5wbvA-5eksA:
undetectable		 5wbvA-5eksA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 HIS A 263
GLU A  72
ASN A 151
 MG  A 401 (-3.3A)
NAD  A 400 (-3.0A)
NAD  A 400 (-3.4A)
 0.56A 5wbvB-5eksA:
undetectable		 5wbvB-5eksA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		5 / 9 LEU A 333
ARG A 280
ALA A 274
VAL A 272
ASP A 276
 None
 1.16A 6c2mB-5eksA:
undetectable		 6c2mB-5eksA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5eks 3-DEHYDROQUINATE
SYNTHASE
(Acinetobacter
baumannii) 		5 / 9 LEU A 333
ARG A 280
ALA A 275
VAL A 272
ASP A 276
 None
 1.38A 6c2mB-5eksA:
undetectable		 6c2mB-5eksA:
13.32