SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 0.96A 1bsxA-5ekuA:
undetectable		 1bsxA-5ekuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 0.96A 1bsxB-5ekuA:
undetectable		 1bsxB-5ekuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 GLU A 101
GLY A 103
SER A 106
GLU A 125
LEU A 130
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.0A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.2A)
 0.32A 1jg4A-5ekuA:
10.0		 1jg4A-5ekuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 SER A 106
GLY A 105
ARG A  81
 SAH  A 401 (-2.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.4A)
 0.66A 1t9wA-5ekuA:
undetectable		 1t9wA-5ekuA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.02A 1xzxX-5ekuA:
undetectable		 1xzxX-5ekuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 0.99A 1y0xX-5ekuA:
undetectable		 1y0xX-5ekuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.03A 2h77A-5ekuA:
undetectable		 2h77A-5ekuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 ARG A  81
SER A 106
LEU A 108
GLY A 107
 SAH  A 401 (-2.4A)
SAH  A 401 (-2.7A)
None
SAH  A 401 ( 4.8A)
 0.89A 2j2pA-5ekuA:
undetectable
2j2pC-5ekuA:
undetectable		 2j2pA-5ekuA:
17.14
2j2pC-5ekuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 ARG A  81
SER A 106
LEU A 108
GLY A 107
 SAH  A 401 (-2.4A)
SAH  A 401 (-2.7A)
None
SAH  A 401 ( 4.8A)
 0.87A 2j2pD-5ekuA:
undetectable
2j2pF-5ekuA:
undetectable		 2j2pD-5ekuA:
17.14
2j2pF-5ekuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 PRO A 317
ASN A 255
ARG A 253
 None
 0.96A 2qeuB-5ekuA:
undetectable		 2qeuB-5ekuA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 ILE A 281
ARG A 278
LEU A 179
ASP A 185
 None
 1.00A 2rlfA-5ekuA:
undetectable
2rlfD-5ekuA:
undetectable		 2rlfA-5ekuA:
8.90
2rlfD-5ekuA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 PHE A 362
CYH A 360
PHE A 287
 None
 0.96A 3cr5X-5ekuA:
undetectable		 3cr5X-5ekuA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ALA A 333
ILE A 281
LEU A 369
THR A 176
ILE A 173
 None
None
None
None
SAH  A 401 ( 4.4A)
 1.20A 3prsA-5ekuA:
undetectable		 3prsA-5ekuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 PRO A 325
ASP A  78
GLU A  79
 None
 0.86A 3v4tC-5ekuA:
undetectable		 3v4tC-5ekuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 CYH A 215
LEU A 218
ALA A 299
LEU A 301
VAL A 257
 None
 1.07A 4x1yB-5ekuA:
undetectable		 4x1yB-5ekuA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 103
GLY A 105
SER A 106
GLU A 125
 SAH  A 401 (-3.0A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.8A)
 0.52A 5ergB-5ekuA:
10.3		 5ergB-5ekuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 184
PHE A 273
ILE A 102
GLY A 103
LEU A 179
 None
None
SAH  A 401 (-4.9A)
SAH  A 401 (-3.0A)
None
 1.11A 5h5fA-5ekuA:
1.9		 5h5fA-5ekuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ALA A 183
VAL A 187
PHE A 174
ILE A 201
 None
 1.04A 5of1A-5ekuA:
undetectable		 5of1A-5ekuA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ALA A 183
VAL A 187
PHE A 174
ILE A 201
 None
 1.01A 5of1B-5ekuA:
undetectable		 5of1B-5ekuA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 CYH A 215
LEU A 334
ILE A 221
MET A 254
LEU A 262
 None
 1.14A 5ycpA-5ekuA:
undetectable		 5ycpA-5ekuA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A 102
LEU A 184
VAL A 188
LEU A 100
LEU A 162
 SAH  A 401 (-4.9A)
None
None
None
None
 1.09A 6b54A-5ekuA:
undetectable		 6b54A-5ekuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 LEU A 109
VAL A  99
VAL A 147
ALA A 114
LEU A  89
 SAH  A 401 (-3.9A)
None
None
None
None
 0.98A 6czmA-5ekuA:
undetectable
6czmC-5ekuA:
undetectable		 6czmA-5ekuA:
22.25
6czmC-5ekuA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLU A 101
ILE A 102
GLY A 103
GLY A 105
LEU A 130
 SAH  A 401 (-3.9A)
SAH  A 401 (-4.9A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.2A)
 0.61A 6iftA-5ekuA:
8.8		 6iftA-5ekuA:
23.88