SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ekz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1
(Mus
musculus) 		5 / 11 VAL A 289
VAL A 286
TYR A 283
LEU A 165
ILE A 161
 None
 1.44A 1t6zB-5ekzA:
undetectable		 1t6zB-5ekzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1
(Mus
musculus) 		5 / 12 LEU A 270
GLY A 139
GLY A 141
ILE A 293
LEU A 276
 None
 0.90A 4gc9A-5ekzA:
undetectable		 4gc9A-5ekzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1
(Mus
musculus) 		5 / 10 LEU A 276
GLY A 139
ASN A 292
ASP A 291
SER A 144
 None
 1.13A 4xj7C-5ekzA:
undetectable
4xj7D-5ekzA:
undetectable		 4xj7C-5ekzA:
21.47
4xj7D-5ekzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1
(Mus
musculus) 		3 / 3 MET A 172
HIS A 158
GLY A 175
 None
 0.85A 5gwzB-5ekzA:
undetectable		 5gwzB-5ekzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ekz TRANSLATIONAL
ACTIVATOR OF
CYTOCHROME C OXIDASE
1
(Mus
musculus) 		5 / 12 VAL A 215
GLU A 217
LEU A 206
ALA A 203
ARG A 240
 None
 1.08A 5nd7B-5ekzA:
undetectable		 5nd7B-5ekzA:
19.52