SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5elx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 390
LEU A 364
LEU A 321
LEU A 324
 None
 0.74A 1errA-5elxA:
undetectable		 1errA-5elxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 198
THR A 215
PRO A 216
GLY A 217
 U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
 0.61A 1h4oB-5elxA:
undetectable		 1h4oB-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 198
THR A 215
PRO A 216
GLY A 217
 U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
 0.57A 1h4oG-5elxA:
undetectable		 1h4oG-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 239
HIS A 422
ASP A 242
 MG  A 502 ( 3.8A)
None
None
 0.83A 1nw5A-5elxA:
4.0		 1nw5A-5elxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 198
THR A 215
PRO A 216
GLY A 217
 U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
 0.61A 1oc3A-5elxA:
undetectable		 1oc3A-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 307
VAL A 403
GLY A 326
VAL A 435
ILE A 437
 None
 0.74A 1t3rB-5elxA:
undetectable		 1t3rB-5elxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 11 THR A 462
VAL A 479
VAL A 435
GLU A 460
ILE A 475
 None
 1.37A 1t6zA-5elxA:
undetectable		 1t6zA-5elxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 CYH A 311
PHE A 439
ASP A 406
TYR A 405
 None
 1.33A 2todA-5elxA:
undetectable
2todB-5elxA:
undetectable		 2todA-5elxA:
22.82
2todB-5elxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 406
TYR A 405
CYH A 311
PHE A 439
 None
 1.38A 2todA-5elxA:
undetectable
2todB-5elxA:
undetectable		 2todA-5elxA:
22.82
2todB-5elxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 406
TYR A 405
CYH A 311
PHE A 439
 None
 1.35A 2todC-5elxA:
undetectable
2todD-5elxA:
undetectable		 2todC-5elxA:
22.82
2todD-5elxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 198
THR A 215
PRO A 216
GLY A 217
 U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
 0.63A 2vl2B-5elxA:
undetectable		 2vl2B-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 212
CYH A 167
ALA A 241
LEU A 267
MET A 152
 None
 1.31A 3adsB-5elxA:
undetectable		 3adsB-5elxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 299
ILE A 304
GLN A 306
GLY A 434
 None
 0.69A 3bjwB-5elxA:
undetectable		 3bjwB-5elxA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 299
ILE A 304
GLN A 306
GLY A 434
 None
 0.72A 3bjwF-5elxA:
undetectable		 3bjwF-5elxA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 299
ILE A 304
GLN A 306
GLY A 434
 None
 0.73A 3bjwH-5elxA:
undetectable		 3bjwH-5elxA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 209
ILE A 196
MET A 228
PHE A 260
LEU A 261
 None
 1.31A 3cl9A-5elxA:
undetectable		 3cl9A-5elxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 182
ARG A 176
ILE A 196
THR A 145
 None
None
None
M2A  A 501 (-3.5A)
 1.34A 3cl9A-5elxA:
1.7		 3cl9A-5elxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 399
ILE A 304
TYR A 308
MET A 309
 None
 1.29A 3gvuA-5elxA:
undetectable		 3gvuA-5elxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 282
VAL A 286
LEU A 245
LEU A 238
ALA A 241
 None
 1.11A 3kw2A-5elxA:
2.7		 3kw2A-5elxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 307
VAL A 403
GLY A 326
VAL A 435
ILE A 437
 None
 0.82A 3oy4A-5elxA:
undetectable		 3oy4A-5elxA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 395
GLU A 184
SER A 400
 M2A  A 501 (-2.7A)
M2A  A 501 (-3.6A)
None
 0.84A 3p2kA-5elxA:
3.1		 3p2kA-5elxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 424
TYR A 420
GLN A 453
SER A 438
MET A 309
 None
 1.42A 4a83A-5elxA:
undetectable		 4a83A-5elxA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 307
VAL A 403
GLY A 326
VAL A 435
ILE A 437
 None
 0.82A 4dqeA-5elxA:
undetectable		 4dqeA-5elxA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 307
VAL A 403
GLY A 326
VAL A 435
ILE A 437
 None
 0.74A 4dqhA-5elxA:
undetectable		 4dqhA-5elxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 217
PRO A 216
ALA A 169
 U  B   5 ( 3.3A)
U  B   4 ( 3.8A)
None
 0.53A 4qn9B-5elxA:
undetectable		 4qn9B-5elxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 360
ILE A 359
LEU A 364
GLU A 368
 None
 0.78A 4w5nA-5elxA:
undetectable		 4w5nA-5elxA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 7 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 0.97A 5btaA-5elxA:
undetectable
5btaC-5elxA:
undetectable
5btaD-5elxA:
2.0		 5btaA-5elxA:
22.65
5btaC-5elxA:
22.65
5btaD-5elxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 0.97A 5btaA-5elxA:
undetectable
5btaB-5elxA:
2.5
5btaC-5elxA:
undetectable		 5btaA-5elxA:
22.65
5btaB-5elxA:
20.96
5btaC-5elxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 1.00A 5btcA-5elxA:
undetectable
5btcC-5elxA:
undetectable
5btcD-5elxA:
2.0		 5btcA-5elxA:
22.65
5btcC-5elxA:
22.65
5btcD-5elxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 1.01A 5btcA-5elxA:
undetectable
5btcB-5elxA:
2.5
5btcC-5elxA:
undetectable		 5btcA-5elxA:
22.65
5btcB-5elxA:
20.96
5btcC-5elxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 182
SER A 193
VAL A 257
CYH A 254
LEU A 168
 None
 1.18A 5ergB-5elxA:
3.1		 5ergB-5elxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 429
HIS A 422
ARG A 426
 BEF  A 503 ( 2.6A)
None
BEF  A 503 (-2.7A)
 1.12A 5iaoC-5elxA:
3.4		 5iaoC-5elxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 429
HIS A 422
ARG A 426
 BEF  A 503 ( 2.6A)
None
BEF  A 503 (-2.7A)
 1.15A 5iaoF-5elxA:
3.4		 5iaoF-5elxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 278
SER A 271
MET A 134
 None
 0.80A 5ikqA-5elxA:
undetectable		 5ikqA-5elxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 MET A 244
GLN A 247
ARG A 392
 None
U  B   2 ( 2.9A)
None
 0.99A 5m36A-5elxA:
undetectable		 5m36A-5elxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 MET A 244
GLN A 247
ARG A 392
 None
U  B   2 ( 2.9A)
None
 1.01A 6fn9A-5elxA:
undetectable		 6fn9A-5elxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 MET A 244
GLN A 247
ARG A 392
 None
U  B   2 ( 2.9A)
None
 1.06A 6fnaB-5elxA:
undetectable		 6fnaB-5elxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 MET A 244
GLN A 247
ARG A 392
 None
U  B   2 ( 2.9A)
None
 1.00A 6fnbA-5elxA:
undetectable		 6fnbA-5elxA:
19.12