SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5emi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 10 ALA A 540
VAL A 577
ILE A 547
GLY A 607
ILE A 575
 None
 0.98A 1hsgA-5emiA:
undetectable		 1hsgA-5emiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		4 / 7 GLY A 558
THR A 559
TYR A 532
ASN A 556
 None
 1.07A 2g70A-5emiA:
undetectable		 2g70A-5emiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		4 / 7 GLY A 558
THR A 559
TYR A 532
ASN A 556
 None
 1.03A 2g70B-5emiA:
undetectable		 2g70B-5emiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		4 / 7 LEU A 460
GLN A 599
ALA A 605
ILE A 476
 None
 0.79A 2xkwA-5emiA:
undetectable		 2xkwA-5emiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 11 SER A 571
LEU A 439
LEU A 612
SER A 574
LEU A 477
 None
 0.95A 2xn5A-5emiA:
undetectable		 2xn5A-5emiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 11 ALA A 540
VAL A 577
ILE A 547
GLY A 607
ILE A 575
 None
 1.01A 3ekxB-5emiA:
undetectable		 3ekxB-5emiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 9 VAL A 543
ILE A 575
ILE A 466
ALA A 603
ILE A 547
 None
 0.99A 3el0B-5emiA:
undetectable		 3el0B-5emiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 11 ILE A 514
ILE A 547
ILE A 608
VAL A 543
GLY A 607
 None
 0.96A 3kw4A-5emiA:
undetectable		 3kw4A-5emiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 11 ILE A 547
ILE A 608
ILE A 514
VAL A 577
VAL A 512
 None
 0.90A 3kw4A-5emiA:
undetectable		 3kw4A-5emiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 11 VAL A 530
LEU A 528
ILE A 604
GLY A 607
LEU A 539
 None
 1.15A 3n8yA-5emiA:
undetectable		 3n8yA-5emiA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 12 SER A 570
ASP A 444
ILE A 443
ALA A 474
VAL A 473
 None
 1.09A 4dx5B-5emiA:
undetectable		 4dx5B-5emiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		4 / 5 GLY A 459
GLY A 456
MET A 582
ASN A 588
 None
 1.17A 4fglC-5emiA:
5.0		 4fglC-5emiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 12 ALA A 454
GLY A 453
ASN A 588
GLY A 456
ASN A 517
 None
 1.28A 4obwD-5emiA:
undetectable		 4obwD-5emiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		4 / 7 LEU A 576
ILE A 547
ILE A 604
VAL A 543
 MES  A 704 (-4.9A)
None
None
None
 0.83A 4ojbA-5emiA:
undetectable		 4ojbA-5emiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		5 / 12 SER A 570
ASP A 444
ILE A 443
ALA A 474
VAL A 473
 None
 1.16A 4u95B-5emiA:
undetectable		 4u95B-5emiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5emi CELL WALL
HYDROLASE/AUTOLYSIN
(Nostoc
punctiforme) 		4 / 5 VAL A 441
LEU A 539
VAL A 530
LEU A 567
 None
 0.50A 6bqgA-5emiA:
undetectable		 6bqgA-5emiA:
16.67