SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5emw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		4 / 5 LEU A 413
ALA A 224
LEU A 228
SER A 326
 None
 1.15A 1tt6B-5emwA:
2.2		 1tt6B-5emwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		5 / 9 LEU A 435
ALA A 296
GLU A 347
GLY A 284
LEU A 288
 None
 1.30A 2v0mB-5emwA:
undetectable		 2v0mB-5emwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		3 / 3 PRO A 279
PHE A 397
LYS A 277
 None
P1L  A 371 ( 4.6A)
None
 1.06A 3bjwG-5emwA:
undetectable		 3bjwG-5emwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		3 / 3 SER A 326
GLU A 410
ASP A 328
 None
 0.85A 3bwmA-5emwA:
undetectable		 3bwmA-5emwA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		4 / 6 LEU A 413
ALA A 224
LEU A 228
SER A 326
 None
 1.11A 4d7bB-5emwA:
1.8		 4d7bB-5emwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		4 / 5 ILE A 399
LEU A 230
HIS A 253
VAL A 252
 None
 1.20A 5jmnB-5emwA:
undetectable		 5jmnB-5emwA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens) 		4 / 6 LEU A 413
ALA A 224
LEU A 228
SER A 326
 None
 1.10A 5l4iB-5emwA:
2.2		 5l4iB-5emwA:
22.75