SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5en2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Mus
musculus;
Argentinian
mammarenavirus) 		3 / 3 VAL A  97
VAL C 117
TRP A  33
 None
 0.92A 1av2A-5en2A:
undetectable
1av2B-5en2A:
undetectable		 1av2A-5en2A:
6.03
1av2B-5en2A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Mus
musculus;
Argentinian
mammarenavirus) 		3 / 3 VAL A  97
VAL C 117
TRP A  33
 None
 0.97A 1w5uA-5en2A:
undetectable
1w5uB-5en2A:
undetectable		 1w5uA-5en2A:
6.03
1w5uB-5en2A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5en2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Argentinian
mammarenavirus) 		4 / 5 LEU C  91
PHE C 192
MET C 215
SER C 111
 None
 1.21A 1wrlC-5en2C:
undetectable		 1wrlC-5en2C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Mus
musculus;
Argentinian
mammarenavirus) 		3 / 3 VAL C 117
TRP A  33
VAL A  97
 None
 0.82A 2izqC-5en2C:
undetectable
2izqD-5en2C:
undetectable		 2izqC-5en2C:
7.30
2izqD-5en2C:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5en2 GD01 HEAVY CHAIN
(Mus
musculus) 		3 / 3 GLY A  53
TRP A  33
VAL A  97
 None
 0.64A 3n62B-5en2A:
undetectable		 3n62B-5en2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5en2 GD01 HEAVY CHAIN
(Mus
musculus) 		3 / 3 GLY A  53
TRP A  33
VAL A  97
 None
 0.61A 3n65B-5en2A:
undetectable		 3n65B-5en2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5en2 GD01 HEAVY CHAIN
(Mus
musculus) 		3 / 3 GLY A  53
TRP A  33
VAL A  97
 None
 0.62A 3n66B-5en2A:
undetectable		 3n66B-5en2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Argentinian
mammarenavirus;
Mus
musculus) 		4 / 7 TYR A  98
GLN C 176
PRO C 204
TYR C 203
 None
NAG  C 601 ( 4.6A)
None
None
 1.29A 3ugrA-5en2A:
undetectable		 3ugrA-5en2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5en2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Argentinian
mammarenavirus) 		4 / 6 PHE C 192
LYS C 193
GLY C 195
ALA C 151
 None
 0.97A 4yshB-5en2C:
undetectable		 4yshB-5en2C:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5en2 GD01 HEAVY CHAIN
(Mus
musculus) 		3 / 3 GLY A  53
TRP A  33
VAL A  97
 None
 0.60A 5vuoB-5en2A:
undetectable		 5vuoB-5en2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 5en2 GD01 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER A 203
ALA A 198
VAL A 197
 None
 0.55A 5xiwC-5en2A:
undetectable		 5xiwC-5en2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 5en2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Argentinian
mammarenavirus) 		5 / 11 PHE C 148
VAL C 152
MET C 196
THR C 179
ILE C 174
 None
 1.42A 6hcoA-5en2C:
undetectable
6hcoB-5en2C:
undetectable		 6hcoA-5en2C:
11.79
6hcoB-5en2C:
11.79