SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5en4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		4 / 4 THR A 189
GLY A  18
ASP A  40
ALA A  90
 NAD  A 301 (-2.8A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 ( 3.8A)
 1.20A 1sg9A-5en4A:
6.5		 1sg9A-5en4A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
ASP A  40
ASP A  62
ASN A  89
ALA A  90
 NAD  A 301 (-3.2A)
NAD  A 301 (-2.8A)
NAD  A 301 (-3.4A)
NAD  A 301 (-3.4A)
NAD  A 301 ( 3.8A)
 0.93A 2bm9E-5en4A:
5.5		 2bm9E-5en4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 9 GLY A  45
GLU A  43
ILE A  38
ALA A  23
VAL A  26
 None
 1.28A 2drdA-5en4A:
undetectable		 2drdA-5en4A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  18
GLY A  24
ASP A  42
ASP A  62
LEU A 113
 NAD  A 301 ( 4.2A)
None
None
NAD  A 301 (-3.4A)
NAD  A 301 (-4.5A)
 1.09A 2hmyB-5en4A:
6.6		 2hmyB-5en4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A 117
ASP A  62
GLY A  16
VAL A  73
VAL A  69
 None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
None
None
 0.95A 2nnkA-5en4A:
undetectable		 2nnkA-5en4A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.89A 2pxcA-5en4A:
5.7		 2pxcA-5en4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.86A 3p97A-5en4A:
5.4		 3p97A-5en4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 11 GLY A  18
ASP A  40
ASP A  42
ASN A  89
LEU A 113
 NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-4.5A)
 1.20A 3v8vB-5en4A:
7.0		 3v8vB-5en4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		6 / 11 GLY A  18
ASP A  40
ASP A  42
ASP A  62
VAL A  63
LEU A 113
 NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
NAD  A 301 (-4.5A)
 0.72A 3v8vB-5en4A:
7.0		 3v8vB-5en4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 11 ILE A  25
ILE A  21
GLY A  20
VAL A 245
GLY A 219
 None
NAD  A 301 (-3.8A)
NAD  A 301 (-3.5A)
None
None
 0.85A 4ac9B-5en4A:
6.5
4ac9C-5en4A:
6.2		 4ac9B-5en4A:
19.79
4ac9C-5en4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		6 / 12 GLY A  16
GLY A  18
ASP A  40
ASP A  62
ALA A  90
LEU A 113
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 (-3.4A)
NAD  A 301 ( 3.8A)
NAD  A 301 (-4.5A)
 1.32A 4iv8A-5en4A:
6.9		 4iv8A-5en4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		6 / 12 GLY A  16
GLY A  18
ASP A  40
ASP A  62
ALA A  90
LEU A 113
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 (-3.4A)
NAD  A 301 ( 3.8A)
NAD  A 301 (-4.5A)
 1.29A 4iv8B-5en4A:
6.0		 4iv8B-5en4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.91A 5ehiA-5en4A:
5.5		 5ehiA-5en4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.91A 5eiwA-5en4A:
5.6		 5eiwA-5en4A:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		8 / 8 HIS A  93
GLN A 148
TYR A 154
LEU A 191
TRP A 192
LEU A 195
MET A 199
THR A 205
 5Q6  A 302 (-3.5A)
5Q6  A 302 (-3.6A)
5Q6  A 302 ( 4.3A)
NAD  A 301 (-3.6A)
5Q6  A 302 ( 3.3A)
5Q6  A 302 (-4.1A)
None
None
 0.33A 5hs6A-5en4A:
45.6		 5hs6A-5en4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.93A 5ikmA-5en4A:
5.4		 5ikmA-5en4A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
ASP A  62
VAL A  63
THR A  64
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
NAD  A 301 ( 4.2A)
 0.70A 5kpcB-5en4A:
undetectable		 5kpcB-5en4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.93A 5kqrA-5en4A:
5.6		 5kqrA-5en4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.93A 5kqsA-5en4A:
5.7		 5kqsA-5en4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.86A 5wz1B-5en4A:
5.3		 5wz1B-5en4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.89A 5wz2A-5en4A:
2.2		 5wz2A-5en4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		5 / 12 GLY A  16
GLY A  18
GLY A  24
ASP A  62
VAL A  63
 NAD  A 301 (-3.2A)
NAD  A 301 ( 4.2A)
None
NAD  A 301 (-3.4A)
NAD  A 301 (-3.7A)
 0.87A 5wz2B-5en4A:
5.6		 5wz2B-5en4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		4 / 6 SER A 173
ARG A 130
GLU A 172
TYR A 175
 None
 1.28A 5x7pB-5en4A:
undetectable		 5x7pB-5en4A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		4 / 6 SER A 173
ARG A 130
GLU A 172
TYR A 175
 None
 1.28A 5x7qA-5en4A:
2.0		 5x7qA-5en4A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		4 / 6 SER A 173
ARG A 130
GLU A 172
TYR A 175
 None
 1.29A 5x7rA-5en4A:
2.0		 5x7rA-5en4A:
12.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens) 		9 / 9 HIS A  93
SER A 141
VAL A 143
GLN A 148
TYR A 154
ASN A 186
LEU A 191
TRP A 192
LEU A 195
 5Q6  A 302 (-3.5A)
5Q6  A 302 ( 2.4A)
5Q6  A 302 ( 4.7A)
5Q6  A 302 (-3.6A)
5Q6  A 302 ( 4.3A)
5Q6  A 302 (-4.4A)
NAD  A 301 (-3.6A)
5Q6  A 302 ( 3.3A)
5Q6  A 302 (-4.1A)
 0.23A 6emmA-5en4A:
44.3		 6emmA-5en4A:
100.00