SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 10 GLY A  64
GLN A 219
ASN A  32
THR A 345
GLY A 233
 None
 1.32A 1kvlA-5enyA:
undetectable		 1kvlA-5enyA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ALA A 440
ILE A 576
LEU A 578
PRO A 579
TYR A 568
 None
 1.13A 1rx8A-5enyA:
undetectable		 1rx8A-5enyA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ALA A 440
LEU A 499
LEU A 578
PRO A 579
TYR A 568
 None
 1.13A 1rx8A-5enyA:
undetectable		 1rx8A-5enyA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLY A 122
GLY A 195
GLY A 237
ASP A 166
SER A 171
 None
 1.15A 1wg8B-5enyA:
undetectable		 1wg8B-5enyA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 GLY A 336
GLU A 302
ASN A 389
 None
 0.67A 1zq9A-5enyA:
undetectable		 1zq9A-5enyA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 PHE A  76
TYR A  99
ALA A 238
ALA A 236
GLY A 194
 None
 1.27A 2igtC-5enyA:
undetectable		 2igtC-5enyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 LEU A 156
VAL A 354
LEU A 358
ARG A 180
 None
 1.03A 2oiqA-5enyA:
undetectable		 2oiqA-5enyA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 LEU A 499
ARG A 496
ALA A 493
ILE A 469
 None
 0.86A 2qhfA-5enyA:
undetectable		 2qhfA-5enyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 GLY A 336
THR A 369
PHE A 381
PHE A 379
 None
 1.01A 2qx4A-5enyA:
undetectable
2qx4B-5enyA:
undetectable		 2qx4A-5enyA:
14.65
2qx4B-5enyA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ILE A   7
SER A 172
GLY A 237
LEU A 359
ASN A 362
 None
 1.18A 2zw9A-5enyA:
undetectable		 2zw9A-5enyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 VAL A 240
GLY A 194
TYR A 120
ILE A 123
GLN A  90
 None
 1.42A 3bwyA-5enyA:
undetectable		 3bwyA-5enyA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 TYR A  23
ASP A  67
GLU A  70
GLU A 234
 None
 1.34A 3dh0A-5enyA:
undetectable		 3dh0A-5enyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 TYR A  23
ASP A  67
GLU A  70
GLU A 234
 None
 1.43A 3dh0B-5enyA:
undetectable		 3dh0B-5enyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLN A 265
GLY A 267
SER A 279
ALA A 277
ALA A 318
 None
 1.11A 3keeD-5enyA:
undetectable		 3keeD-5enyA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 GLU A 483
TYR A 455
TYR A 581
PHE A 155
 None
 1.36A 3ku9B-5enyA:
undetectable		 3ku9B-5enyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.96A 3sudA-5enyA:
undetectable		 3sudA-5enyA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.91A 3sudC-5enyA:
undetectable		 3sudC-5enyA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.93A 3sudD-5enyA:
undetectable		 3sudD-5enyA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 6 MET A 489
LEU A 444
PRO A 579
TYR A 455
 None
 1.30A 3vkxA-5enyA:
undetectable		 3vkxA-5enyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 VAL A 193
LEU A 239
LEU A 241
ILE A 419
 None
 0.95A 4a9jB-5enyA:
undetectable		 4a9jB-5enyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLY A 353
ALA A 349
SER A 408
VAL A 407
ILE A 421
 None
 0.96A 4ax8A-5enyA:
2.3		 4ax8A-5enyA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 TYR A  14
VAL A  20
TYR A  23
LEU A 239
 None
 1.09A 4jtrA-5enyA:
undetectable		 4jtrA-5enyA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 ARG A  41
ARG A  13
ASP A  88
GLU A 127
 None
 1.25A 4kr4C-5enyA:
undetectable		 4kr4C-5enyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 9 SER A 125
ALA A 148
LEU A 121
GLY A 122
ALA A 580
 None
 1.27A 4l6va-5enyA:
undetectable
4l6vf-5enyA:
undetectable		 4l6va-5enyA:
21.59
4l6vf-5enyA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		6 / 12 ALA A 168
CYH A 169
HIS A 304
THR A 306
HIS A 344
GLY A 411
 None
 0.44A 4ls7A-5enyA:
49.1		 4ls7A-5enyA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		6 / 12 ALA A 168
CYH A 169
HIS A 304
THR A 306
HIS A 344
GLY A 411
 None
 0.45A 4ls7A-5enyA:
49.1
4ls7B-5enyA:
49.0		 4ls7A-5enyA:
23.55
4ls7B-5enyA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 4 ILE A 298
VAL A 407
VAL A 420
ARG A 404
 None
 1.34A 4m6tA-5enyA:
undetectable		 4m6tA-5enyA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 GLN A 479
THR A 477
LEU A 578
THR A 464
 None
 1.04A 4mbsA-5enyA:
undetectable		 4mbsA-5enyA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 9 ALA A 405
ILE A 258
GLY A 260
ILE A 287
VAL A 357
 None
 1.13A 4nptA-5enyA:
undetectable		 4nptA-5enyA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLY A 233
GLY A 235
ALA A  33
ILE A  34
ALA A 347
 None
 1.21A 5bw4B-5enyA:
undetectable		 5bw4B-5enyA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_C_ACTC1742_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SUBUNIT)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 ASP A  45
LYS A  46
THR A  39
ASP A  43
 None
 1.33A 5g5hC-5enyA:
0.0		 5g5hC-5enyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 ASN A 376
PHE A 379
THR A 369
GLY A 336
 None
 0.76A 5nzxA-5enyA:
undetectable		 5nzxA-5enyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 ASN A 376
PHE A 379
THR A 369
GLY A 336
 None
 0.79A 5nzyA-5enyA:
2.1		 5nzyA-5enyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 SER A 408
GLY A 353
ALA A 352
SER A 171
GLU A 315
 None
 1.48A 5wbvA-5enyA:
undetectable		 5wbvA-5enyA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 MET A 190
ASP A 252
ARG A 482
 None
 0.98A 5z6jA-5enyA:
undetectable		 5z6jA-5enyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 SER A 279
LYS A 278
SER A 276
 None
 0.70A 6az3P-5enyA:
undetectable		 6az3P-5enyA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 6 ILE A 293
TYR A 288
VAL A 420
SER A 297
 None
 1.25A 6f6jA-5enyA:
undetectable		 6f6jA-5enyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5eny POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 6 LEU A 578
THR A 477
GLY A 106
ARG A 482
 None
 1.37A 6gtqB-5enyA:
undetectable
6gtqD-5enyA:
undetectable		 6gtqB-5enyA:
14.95
6gtqD-5enyA:
5.78