SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5enz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 11 LEU A  20
ALA A  23
ALA A 353
THR A 173
VAL A 117
 None
 1.11A 1ictA-5enzA:
undetectable
1ictC-5enzA:
undetectable		 1ictA-5enzA:
18.48
1ictC-5enzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 ASN A 346
GLY A 284
ILE A 285
ILE A 175
 None
UDP  A 401 (-3.5A)
None
None
 0.78A 1n49D-5enzA:
undetectable		 1n49D-5enzA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 7 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.12A 1tv8A-5enzA:
3.2		 1tv8A-5enzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 7 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.13A 1tv8B-5enzA:
undetectable		 1tv8B-5enzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 ARG A 136
GLY A 120
ALA A 119
HIS A 156
 None
 0.99A 1wrqA-5enzA:
undetectable		 1wrqA-5enzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 ARG A 136
GLY A 120
ALA A 119
HIS A 156
 None
 0.99A 1wrqB-5enzA:
undetectable		 1wrqB-5enzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 8 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.14A 2fb2A-5enzA:
3.4		 2fb2A-5enzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 7 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.18A 2fb2B-5enzA:
3.4		 2fb2B-5enzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 PRO A 295
LEU A 297
LYS A 315
GLY A 308
 None
 1.08A 2hs2B-5enzA:
undetectable		 2hs2B-5enzA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		6 / 12 THR A 100
ILE A 114
GLY A 115
HIS A 116
ASN A 135
LEU A 105
 None
 1.50A 3eeyD-5enzA:
3.8		 3eeyD-5enzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 11 GLU A  13
VAL A  91
ALA A 106
THR A 100
THR A  99
 TRS  A 403 (-4.6A)
None
None
None
None
 1.27A 3mdzA-5enzA:
undetectable		 3mdzA-5enzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		6 / 12 ILE A  53
LEU A  48
ALA A 177
THR A 181
VAL A 266
VAL A  47
 None
 1.43A 3rukA-5enzA:
undetectable		 3rukA-5enzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		3 / 3 ARG A 300
ARG A 136
ASP A 125
 None
 0.72A 3wipG-5enzA:
undetectable
3wipH-5enzA:
undetectable		 3wipG-5enzA:
20.85
3wipH-5enzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 8 ASP A 176
ASN A 346
GLU A 287
ASP A 350
 None
 1.01A 4feuD-5enzA:
undetectable		 4feuD-5enzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 ARG A 305
GLY A 308
ALA A 153
GLU A 307
 TRS  A 403 ( 4.5A)
None
None
None
 1.13A 4g0uA-5enzA:
undetectable		 4g0uA-5enzA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 5 TYR A 194
ARG A 256
ASP A 226
VAL A 324
 None
 1.46A 4nkvB-5enzA:
undetectable		 4nkvB-5enzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 12 TYR A 109
ASN A 110
ALA A 102
GLY A 103
GLY A 104
 None
 1.02A 4obwB-5enzA:
undetectable		 4obwB-5enzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 12 LEU A  20
GLY A 171
GLY A 349
PRO A 347
GLU A 287
 None
 1.31A 4x61A-5enzA:
undetectable		 4x61A-5enzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 12 VAL A 265
PRO A  19
ALA A  18
VAL A  47
SER A 282
 UDP  A 401 (-3.7A)
None
None
None
UDP  A 401 (-2.7A)
 1.22A 5hv1A-5enzA:
undetectable		 5hv1A-5enzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 11 THR A 203
ALA A 204
VAL A 296
GLY A 284
GLY A 283
 UDP  A 401 ( 4.4A)
None
None
UDP  A 401 (-3.5A)
UDP  A 401 (-3.8A)
 0.86A 5lf7K-5enzA:
undetectable
5lf7L-5enzA:
undetectable		 5lf7K-5enzA:
20.00
5lf7L-5enzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 11 THR A 203
ALA A 204
VAL A 296
GLY A 284
GLY A 283
 UDP  A 401 ( 4.4A)
None
None
UDP  A 401 (-3.5A)
UDP  A 401 (-3.8A)
 0.85A 5lf7Y-5enzA:
undetectable
5lf7Z-5enzA:
undetectable		 5lf7Y-5enzA:
20.00
5lf7Z-5enzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5enz UDP-GLCNAC
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ALA A  18
VAL A  34
GLY A   9
THR A  97
THR A   6
 None
None
None
TRS  A 403 ( 4.9A)
None
 1.42A 5w5vA-5enzA:
undetectable		 5w5vA-5enzA:
21.50