SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 0.95A 1axwA-5eo9B:
undetectable		 1axwA-5eo9B:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 1.00A 1hvyD-5eo9B:
undetectable		 1hvyD-5eo9B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5eo9 DPR6, ISOFORM C
(Drosophila
melanogaster) 		4 / 8 ASP A 126
PHE A 129
ASP A 112
THR A 122
 None
 1.12A 1rmtD-5eo9A:
undetectable		 1rmtD-5eo9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 0.97A 1tlsA-5eo9B:
undetectable		 1tlsA-5eo9B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 0.97A 1tlsB-5eo9B:
undetectable		 1tlsB-5eo9B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 0.94A 1tsnA-5eo9B:
undetectable		 1tsnA-5eo9B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 10 LEU B 207
LEU B 209
SER B 239
LEU B 238
LEU B 165
 None
 1.08A 2xn7A-5eo9B:
undetectable
2xn7B-5eo9B:
undetectable		 2xn7A-5eo9B:
21.25
2xn7B-5eo9B:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 1.03A 4fogD-5eo9B:
undetectable		 4fogD-5eo9B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5eo9 DPR6, ISOFORM C
(Drosophila
melanogaster) 		4 / 8 ILE A 108
GLU A 156
GLN A 158
ILE A 159
 None
 0.82A 4mj8A-5eo9A:
undetectable		 4mj8A-5eo9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 9 VAL B  45
ASN B 105
GLY B  69
LEU B  68
GLN B 104
 None
None
SO4  B 902 ( 4.7A)
None
SO4  B 903 (-4.2A)
 1.24A 6czmB-5eo9B:
undetectable
6czmC-5eo9B:
undetectable		 6czmB-5eo9B:
19.18
6czmC-5eo9B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5eo9 DPR6, ISOFORM C
(Drosophila
melanogaster) 		4 / 7 ASP A 151
ARG A 109
TYR A 155
ASP A 112
 None
 1.23A 6mn5E-5eo9A:
undetectable		 6mn5E-5eo9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5eo9 CG32791, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE B 135
LEU B 109
GLY B 120
PHE B 137
ALA B  82
 None
None
None
NAG  B 901 ( 4.6A)
None
 0.97A 6r2eE-5eo9B:
undetectable		 6r2eE-5eo9B:
18.67