SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eor'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		3 / 3 VAL L 104
VAL L  95
TRP H  48
 None
 0.94A 1av2C-5eorL:
undetectable
1av2D-5eorL:
undetectable		 1av2C-5eorL:
6.25
1av2D-5eorL:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 7 LEU H  28
VAL H  35
TYR H 100
GLY H  34
 None
NA  H 301 ( 4.9A)
None
NA  H 301 ( 3.8A)
 0.94A 1lweA-5eorH:
undetectable		 1lweA-5eorH:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		5 / 12 LEU L  78
LEU L  21
ILE L  63
ILE L  83
ARG L  66
 None
 1.12A 1tw4B-5eorL:
undetectable		 1tw4B-5eorL:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		3 / 3 VAL L 104
VAL L  95
TRP H  48
 None
 0.97A 1w5uC-5eorL:
undetectable
1w5uD-5eorL:
undetectable		 1w5uC-5eorL:
6.25
1w5uD-5eorL:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 6 VAL H  38
LEU H  49
PHE H  64
MET H  83
 None
 1.13A 1x8vA-5eorH:
undetectable		 1x8vA-5eorH:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		5 / 12 ALA H  92
ILE H  93
PHE L 107
ILE L  90
GLN L  39
 None
 1.08A 1xozA-5eorH:
undetectable		 1xozA-5eorH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		4 / 6 LEU L  78
TYR L  91
ILE L  63
ILE L  80
 None
 0.97A 2q8hA-5eorL:
undetectable		 2q8hA-5eorL:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		3 / 3 THR L 124
SER L 147
PHE L 128
 None
 0.77A 3d4sA-5eorL:
undetectable		 3d4sA-5eorL:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		4 / 4 GLY L  96
TYR L 105
GLY L  94
ASP L  35
 None
 1.07A 3kl3A-5eorL:
undetectable		 3kl3A-5eorL:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		5 / 12 PHE H 169
VAL L 204
VAL L 154
PRO L 123
PHE L 149
 None
 1.48A 3nbrA-5eorH:
undetectable		 3nbrA-5eorH:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 7 LEU H  28
VAL H  35
TYR H 100
LEU H   5
 None
NA  H 301 ( 4.9A)
None
None
 1.14A 4b3qA-5eorH:
undetectable		 4b3qA-5eorH:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.92A 4f8hA-5eorH:
undetectable
4f8hB-5eorH:
undetectable		 4f8hA-5eorH:
19.63
4f8hB-5eorH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.94A 4f8hB-5eorH:
undetectable
4f8hC-5eorH:
undetectable		 4f8hB-5eorH:
19.63
4f8hC-5eorH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.91A 4f8hC-5eorH:
undetectable
4f8hD-5eorH:
undetectable		 4f8hC-5eorH:
19.63
4f8hD-5eorH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR H  94
ASP H  89
PHE H  64
LEU H  49
 None
 0.92A 4f8hD-5eorH:
undetectable
4f8hE-5eorH:
undetectable		 4f8hD-5eorH:
19.63
4f8hE-5eorH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		4 / 8 PHE H  64
LEU H  49
TYR H  94
ASP H  89
 None
 0.92A 4f8hA-5eorH:
undetectable
4f8hE-5eorH:
undetectable		 4f8hA-5eorH:
19.63
4f8hE-5eorH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		4 / 7 VAL H 124
PRO H 126
LYS L 136
GLU L 137
 None
 1.12A 4lb2A-5eorH:
undetectable		 4lb2A-5eorH:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		4 / 5 ARG L  52
THR L  33
ASP L  35
TYR L  47
 None
 1.38A 4oltB-5eorL:
undetectable		 4oltB-5eorL:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		4 / 5 ARG L  52
THR L  33
ASP L  35
TYR L  47
 None
 1.43A 4oltB-5eorL:
undetectable		 4oltB-5eorL:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		3 / 3 ASN L 148
SER L 121
SER L 150
 None
 0.68A 5gsnA-5eorL:
undetectable		 5gsnA-5eorL:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		4 / 8 THR H 185
SER H 138
THR L 124
THR L 126
 None
 1.02A 5l4eA-5eorH:
undetectable
5l4eB-5eorH:
undetectable
5l4eC-5eorH:
2.5
5l4eD-5eorH:
undetectable
5l4eE-5eorH:
undetectable		 5l4eA-5eorH:
19.94
5l4eB-5eorH:
19.94
5l4eC-5eorH:
19.94
5l4eD-5eorH:
19.94
5l4eE-5eorH:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		5 / 5 SER H 115
ALA H 117
PHE H 149
LEU H 173
ASP H 176
 None
 0.55A 5mthA-5eorH:
26.7		 5mthA-5eorH:
62.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN
(Mus
musculus) 		5 / 9 THR H 140
SER H 183
THR L 126
THR L 124
SER L 147
 None
 0.95A 5muoA-5eorH:
undetectable
5muoB-5eorH:
undetectable
5muoC-5eorH:
undetectable
5muoD-5eorH:
undetectable
5muoE-5eorH:
undetectable		 5muoA-5eorH:
16.35
5muoB-5eorH:
16.35
5muoC-5eorH:
16.35
5muoD-5eorH:
16.35
5muoE-5eorH:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY H  11
SER H  20
LEU H  19
VAL H  13
LEU H  86
 None
 1.28A 5ubbA-5eorH:
undetectable		 5ubbA-5eorH:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 206
ALA H 201
VAL H 200
 None
 0.53A 5xiwC-5eorH:
undetectable		 5xiwC-5eorH:
13.76