SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 10 ASP A  88
GLY A  90
ALA A  91
ASP A 112
VAL A  99
 None
 0.96A 1t3rA-5eovA:
undetectable		 1t3rA-5eovA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ASP A  88
GLY A  90
GLY A  95
ASP A 154
 None
 0.67A 2oxtD-5eovA:
13.2		 2oxtD-5eovA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 240
ALA A 227
ALA A  89
ALA A  91
THR A  93
 None
 1.22A 2x2nA-5eovA:
undetectable		 2x2nA-5eovA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 240
ALA A 227
ALA A  89
ALA A  91
THR A  93
 None
 1.23A 2x2nB-5eovA:
undetectable		 2x2nB-5eovA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 240
LEU A 180
GLU A 238
ALA A  67
SER A  64
 None
 1.42A 3apvA-5eovA:
undetectable		 3apvA-5eovA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 166
LEU A 155
ILE A 177
GLY A  90
ALA A 111
 None
 1.38A 3lbdA-5eovA:
undetectable		 3lbdA-5eovA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		4 / 7 ASP A  88
ALA A  91
ASP A 112
VAL A 130
 None
 0.68A 3t3cA-5eovA:
undetectable		 3t3cA-5eovA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 139
GLY A  90
ALA A  91
VAL A 109
VAL A 108
 None
 1.13A 4nkvC-5eovA:
undetectable		 4nkvC-5eovA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 139
GLY A  90
ALA A  91
VAL A 109
VAL A 108
 None
 1.15A 4nkvD-5eovA:
undetectable		 4nkvD-5eovA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 11 ASP A  88
GLY A  90
ALA A  91
ASP A 112
VAL A  99
 None
 0.95A 4qgiA-5eovA:
undetectable		 4qgiA-5eovA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 114
LEU A 155
ALA A  89
ASP A  88
ALA A 110
 None
 1.14A 4wnuD-5eovA:
undetectable		 4wnuD-5eovA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  74
PHE A  77
LEU A  70
PHE A  96
 None
 1.27A 5xdxP-5eovA:
undetectable
5xdxW-5eovA:
undetectable		 5xdxP-5eovA:
22.92
5xdxW-5eovA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 190
GLY A 193
PRO A 194
GLY A 196
 None
 0.59A 6ag0C-5eovA:
undetectable		 6ag0C-5eovA:
14.75