SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A  11
GLY A  13
ALA A  18
GLN A  35
LEU A 130
 FAD  A 401 (-3.0A)
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.3A)
FAD  A 401 (-4.6A)
 1.03A 1i9gA-5eowA:
3.3		 1i9gA-5eowA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		4 / 7 GLU A 312
VAL A 366
TRP A 356
ASN A  51
 None
 1.33A 1jqdA-5eowA:
undetectable		 1jqdA-5eowA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A  15
GLY A  16
VAL A 124
LEU A 111
HIS A 112
 FAD  A 401 (-3.3A)
None
None
None
None
 0.92A 1ya4C-5eowA:
undetectable		 1ya4C-5eowA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 169
LEU A 283
GLY A 157
ASP A 159
ALA A   8
 None
 1.28A 2bm9B-5eowA:
2.9		 2bm9B-5eowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A  13
ALA A  12
VAL A 124
VAL A  30
VAL A  32
 FAD  A 401 (-3.4A)
None
None
None
None
 0.90A 2ieoB-5eowA:
undetectable		 2ieoB-5eowA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		4 / 7 GLY A  16
LEU A  61
PHE A  56
THR A  21
 None
 0.77A 2vl2B-5eowA:
undetectable		 2vl2B-5eowA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 ARG A 184
GLY A 306
ALA A 307
GLY A 160
ILE A 161
 FAD  A 401 (-3.9A)
FAD  A 401 (-3.1A)
FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
None
 0.92A 3d20A-5eowA:
undetectable		 3d20A-5eowA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 ARG A 166
ASP A 313
TYR A 336
PRO A 282
 None
 0.99A 3jqaC-5eowA:
5.4		 3jqaC-5eowA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 VAL A 203
LEU A 263
THR A 259
HIS A 195
TRP A 205
 None
 1.32A 3lxeA-5eowA:
undetectable		 3lxeA-5eowA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 VAL A 203
LEU A 263
THR A 259
HIS A 195
TRP A 205
 None
 1.32A 3lxeB-5eowA:
undetectable		 3lxeB-5eowA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 317
ALA A 315
LEU A  22
ILE A   9
GLY A  16
 None
 1.10A 3q95A-5eowA:
undetectable		 3q95A-5eowA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 317
ALA A 315
LEU A  22
ILE A   9
GLY A  16
 None
 1.06A 3q95B-5eowA:
undetectable		 3q95B-5eowA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 9 ALA A 295
ASP A 294
GLY A  16
ILE A   9
LEU A 130
 None
FAD  A 401 (-3.1A)
None
None
FAD  A 401 (-4.6A)
 1.18A 3u7sB-5eowA:
undetectable		 3u7sB-5eowA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 9 ALA A 295
ASP A 294
GLY A  16
ILE A   9
LEU A 130
 None
FAD  A 401 (-3.1A)
None
None
FAD  A 401 (-4.6A)
 1.10A 3u7sA-5eowA:
undetectable		 3u7sA-5eowA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 291
VAL A 290
ARG A 286
VAL A  10
LEU A 142
 None
None
None
FAD  A 401 (-4.7A)
None
 1.45A 3vt7A-5eowA:
undetectable		 3vt7A-5eowA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 11 TRP A 356
LEU A 357
GLY A  49
TYR A  99
VAL A 366
 None
 1.23A 4fogC-5eowA:
undetectable		 4fogC-5eowA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 171
SER A 285
ASP A 313
GLY A 293
PRO A 282
 None
None
None
FAD  A 401 (-3.2A)
None
 0.93A 4fp9D-5eowA:
2.1		 4fp9D-5eowA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 171
SER A 285
ASP A 313
GLY A 293
PRO A 282
 None
None
None
FAD  A 401 (-3.2A)
None
 0.90A 4fzvA-5eowA:
undetectable		 4fzvA-5eowA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A  23
GLY A  27
LEU A 326
THR A 123
ILE A 119
 None
 1.02A 4p6xA-5eowA:
undetectable		 4p6xA-5eowA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A  23
GLY A  27
LEU A 326
THR A 123
ILE A 119
 None
 1.05A 4p6xE-5eowA:
undetectable		 4p6xE-5eowA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A  23
GLY A  27
LEU A 326
THR A 123
ILE A 119
 None
 1.10A 4p6xI-5eowA:
undetectable		 4p6xI-5eowA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLU A  62
ARG A  57
ALA A 315
ILE A 311
ARG A  58
 None
 1.17A 4uroC-5eowA:
undetectable		 4uroC-5eowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 371
LEU A  65
MET A  68
ILE A  46
ALA A  18
 None
None
None
FAD  A 401 (-4.6A)
None
 1.16A 5ienB-5eowA:
undetectable		 5ienB-5eowA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 292
SER A 163
GLY A 160
GLY A  11
VAL A  10
 None
None
FAD  A 401 (-3.5A)
FAD  A 401 (-3.0A)
FAD  A 401 (-4.7A)
 1.30A 5o4yD-5eowA:
undetectable
5o4yE-5eowA:
undetectable		 5o4yD-5eowA:
3.20
5o4yE-5eowA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		4 / 8 ILE A   7
ALA A 152
LEU A 289
ILE A   9
 None
 0.87A 5uihA-5eowA:
undetectable		 5uihA-5eowA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 PHE A  33
ARG A 129
ALA A   8
GLN A  35
 None
None
None
FAD  A 401 (-3.3A)
 1.03A 6b89B-5eowA:
undetectable		 6b89B-5eowA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE
(Pseudomonas
putida) 		4 / 8 ASP A 313
TYR A 336
GLY A 287
VAL A 155
 None
 0.90A 6giqL-5eowA:
undetectable
6giqP-5eowA:
undetectable
6giqT-5eowA:
undetectable		 6giqL-5eowA:
21.01
6giqP-5eowA:
19.51
6giqT-5eowA:
11.00