SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ep1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 208
LEU A 211
LEU A 250
LEU A 299
LEU A 238
 None
 1.16A 1errB-5ep1A:
undetectable		 1errB-5ep1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 11 VAL A 346
VAL A 378
GLU A 351
LEU A 362
ILE A 366
 None
 1.29A 1t6zB-5ep1A:
undetectable		 1t6zB-5ep1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		4 / 6 VAL A 359
PHE A 142
MET A 149
SER A 146
 ACT  A 404 ( 4.9A)
ACT  A 404 (-4.8A)
None
None
 1.04A 1wrlB-5ep1A:
undetectable		 1wrlB-5ep1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 11 ARG A 277
ILE A 168
ALA A 182
ALA A 180
VAL A 279
 None
 1.18A 2qhfA-5ep1A:
undetectable		 2qhfA-5ep1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.34A 3g1uC-5ep1A:
undetectable		 3g1uC-5ep1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 10 GLN A 259
LEU A 238
VAL A 276
VAL A 230
LEU A 211
 None
 1.07A 3gwxA-5ep1A:
undetectable		 3gwxA-5ep1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		4 / 6 SER A 187
VAL A 166
THR A 165
ARG A 277
 None
None
ACT  A 402 ( 4.9A)
None
 1.22A 4lnxA-5ep1A:
undetectable		 4lnxA-5ep1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.35A 4pfjB-5ep1A:
undetectable		 4pfjB-5ep1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.31A 4pgfA-5ep1A:
undetectable		 4pgfA-5ep1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.32A 4pgfB-5ep1A:
undetectable		 4pgfB-5ep1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 11 ALA A 229
ALA A 233
LEU A 238
LEU A 254
TYR A 263
 None
 1.28A 5eb5A-5ep1A:
undetectable		 5eb5A-5ep1A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.37A 6aphA-5ep1A:
undetectable		 6aphA-5ep1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.39A 6f3nC-5ep1A:
undetectable		 6f3nC-5ep1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.47A 6gbnB-5ep1A:
undetectable		 6gbnB-5ep1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO
(Photobacterium
angustum) 		5 / 12 GLU A 177
ASP A 241
LEU A 310
MET A 239
PHE A 194
 None
 1.48A 6gbnC-5ep1A:
undetectable		 6gbnC-5ep1A:
22.55