SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5epa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 5 THR A 135
GLU A 124
THR A 125
HIS A 210
 None
None
None
FE  A 300 ( 3.3A)
 1.39A 1d4fD-5epaA:
undetectable		 1d4fD-5epaA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 5 THR A 137
ASP A 123
HIS A 121
HIS A 204
HIS A 210
 AKG  A 301 ( 4.3A)
FE  A 300 ( 2.5A)
FE  A 300 ( 3.3A)
AKG  A 301 (-4.4A)
FE  A 300 ( 3.3A)
 1.31A 1ei6A-5epaA:
undetectable		 1ei6A-5epaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 8 THR A 137
ASP A 123
HIS A 121
HIS A 204
HIS A 210
 AKG  A 301 ( 4.3A)
FE  A 300 ( 2.5A)
FE  A 300 ( 3.3A)
AKG  A 301 (-4.4A)
FE  A 300 ( 3.3A)
 1.37A 1ei6C-5epaA:
undetectable		 1ei6C-5epaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 9 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.74A 1ohrB-5epaA:
undetectable		 1ohrB-5epaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 12 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.71A 2avoB-5epaA:
undetectable		 2avoB-5epaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 12 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.78A 2bpxB-5epaA:
undetectable		 2bpxB-5epaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 12 LEU A  95
ILE A  88
THR A   8
VAL A  32
VAL A  27
 None
 1.15A 2g78A-5epaA:
undetectable		 2g78A-5epaA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 12 GLY A 126
ASN A 130
THR A 135
LEU A 244
LEU A 247
 None
 1.04A 2hw2A-5epaA:
undetectable		 2hw2A-5epaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 12 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.76A 2o4sA-5epaA:
undetectable		 2o4sA-5epaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 12 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.79A 2r5pB-5epaA:
undetectable		 2r5pB-5epaA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 11 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.87A 3ekxB-5epaA:
undetectable		 3ekxB-5epaA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 10 LEU A 108
THR A 118
HIS A 121
ASP A 123
HIS A 210
 AKG  A 301 ( 3.7A)
AKG  A 301 (-3.2A)
FE  A 300 ( 3.3A)
FE  A 300 ( 2.5A)
FE  A 300 ( 3.3A)
 0.73A 3kcxA-5epaA:
11.1		 3kcxA-5epaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 11 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.79A 3lzvB-5epaA:
undetectable		 3lzvB-5epaA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 11 ALA A 223
VAL A  66
ALA A 214
ALA A 212
SER A 217
 None
None
None
AKG  A 301 (-3.4A)
None
 0.92A 3mg0K-5epaA:
undetectable
3mg0L-5epaA:
undetectable		 3mg0K-5epaA:
23.10
3mg0L-5epaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 5 LEU A 132
THR A 135
GLU A 124
HIS A 169
 None
 1.36A 3n58C-5epaA:
undetectable		 3n58C-5epaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 10 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.73A 3nu6A-5epaA:
undetectable		 3nu6A-5epaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 10 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.82A 3nujA-5epaA:
undetectable		 3nujA-5epaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 10 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.82A 3oxvB-5epaA:
undetectable		 3oxvB-5epaA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 11 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.82A 3oxvD-5epaA:
undetectable		 3oxvD-5epaA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5epa SNOK
(Streptomyces
nogalater) 		3 / 3 LYS A 110
ARG A 221
TRP A 139
 AKG  A 301 (-4.2A)
AKG  A 301 (-2.7A)
AKG  A 301 (-4.3A)
 1.24A 4i90A-5epaA:
undetectable		 4i90A-5epaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 11 ALA A  72
GLN A  74
VAL A  66
HIS A  67
LEU A  49
 None
 1.16A 4nqaA-5epaA:
undetectable		 4nqaA-5epaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 7 VAL A  27
LEU A  13
VAL A  32
THR A   8
 None
 0.90A 5e4dA-5epaA:
undetectable
5e4dB-5epaA:
undetectable		 5e4dA-5epaA:
23.24
5e4dB-5epaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 4 VAL A 194
VAL A 192
TYR A 154
GLN A  24
 None
 1.37A 5qggA-5epaA:
undetectable		 5qggA-5epaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 4 VAL A 194
VAL A 192
TYR A 154
GLN A  24
 None
 1.36A 5qgoA-5epaA:
undetectable		 5qgoA-5epaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 4 VAL A 194
VAL A 192
TYR A 154
GLN A  24
 None
 1.33A 5qgpA-5epaA:
undetectable		 5qgpA-5epaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 4 VAL A 194
VAL A 192
TYR A 154
GLN A  24
 None
 1.36A 5qgqA-5epaA:
undetectable		 5qgqA-5epaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 4 VAL A 194
VAL A 192
TYR A 154
GLN A  24
 None
 1.38A 5qhbA-5epaA:
undetectable		 5qhbA-5epaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5epa SNOK
(Streptomyces
nogalater) 		3 / 3 MET A 229
GLU A 254
ARG A 101
 None
 1.03A 5tjyA-5epaA:
undetectable		 5tjyA-5epaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5epa SNOK
(Streptomyces
nogalater) 		3 / 3 MET A 229
GLU A 254
ARG A 101
 None
 1.10A 5tjzA-5epaA:
undetectable		 5tjzA-5epaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5epa SNOK
(Streptomyces
nogalater) 		3 / 3 GLU A 131
LEU A 132
ARG A 207
 None
 0.65A 6d8fA-5epaA:
undetectable		 6d8fA-5epaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 5epa SNOK
(Streptomyces
nogalater) 		5 / 10 VAL A 201
ILE A  88
GLY A  90
VAL A  27
ILE A  29
 None
 0.90A 6dj2A-5epaA:
undetectable		 6dj2A-5epaA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5epa SNOK
(Streptomyces
nogalater) 		4 / 8 VAL A 155
TYR A 186
HIS A 121
GLU A 124
 None
None
FE  A 300 ( 3.3A)
None
 1.13A 6gneB-5epaA:
undetectable		 6gneB-5epaA:
19.48