SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5epd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 7 GLN A  60
THR A  71
TYR A  68
GLN A 100
 None
 1.15A 1eiiA-5epdA:
undetectable		 1eiiA-5epdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 9 THR A  59
PRO A  72
GLY A  73
PHE A 170
GLY A  82
 None
 1.29A 1h4oE-5epdA:
undetectable
1h4oF-5epdA:
undetectable		 1h4oE-5epdA:
18.39
1h4oF-5epdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 9 LEU A   6
GLY A  52
ALA A  51
LEU A 326
PHE A 316
 None
 1.17A 1nr6A-5epdA:
undetectable		 1nr6A-5epdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		3 / 3 GLN A  60
ILE A  61
TYR A  75
 None
 0.69A 1vifA-5epdA:
undetectable		 1vifA-5epdA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 8 ILE A 154
ARG A 144
LEU A 146
GLU A 150
 None
 0.68A 2cdqA-5epdA:
undetectable		 2cdqA-5epdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 11 TYR A 261
GLU A 266
VAL A 264
ILE A 229
HIS A 176
 None
 1.26A 2dg3A-5epdA:
undetectable		 2dg3A-5epdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 10 THR A  59
PRO A  72
GLY A  73
PHE A 170
GLY A  82
 None
 1.24A 2vl2A-5epdA:
undetectable
2vl2C-5epdA:
undetectable		 2vl2A-5epdA:
20.52
2vl2C-5epdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 5 ILE A 107
THR A  27
PHE A 345
PHE A 137
 None
 1.22A 3em0A-5epdA:
undetectable		 3em0A-5epdA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 12 ASP A 312
VAL A 264
ALA A 260
LEU A 254
ILE A 227
 None
 1.05A 3ku1H-5epdA:
undetectable		 3ku1H-5epdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 12 ILE A  97
LEU A  17
GLY A 172
PHE A 170
ILE A  55
 None
 1.00A 3uwlB-5epdA:
undetectable		 3uwlB-5epdA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 9 ALA A  24
PRO A  25
GLN A 100
ARG A 228
ASN A 294
 None
 1.15A 4a3uA-5epdA:
52.7		 4a3uA-5epdA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 9 ALA A  24
PRO A  25
ILE A  55
ARG A 228
ASN A 294
 None
 0.36A 4a3uA-5epdA:
52.7		 4a3uA-5epdA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 7 THR A  27
TRP A 102
HIS A 176
ASN A 179
TYR A 181
 None
 0.32A 4a3uA-5epdA:
52.7		 4a3uA-5epdA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 7 THR A  27
TRP A 102
HIS A 176
ASN A 179
TYR A 181
 None
 0.32A 4a3uB-5epdA:
52.9		 4a3uB-5epdA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		6 / 7 THR A  27
TRP A 102
HIS A 176
ASN A 179
TYR A 181
PHE A 345
 None
 0.36A 4awuA-5epdA:
54.0		 4awuA-5epdA:
46.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 6 TYR A  68
PHE A 132
PHE A 137
PHE A 345
 None
 0.98A 4awuA-5epdA:
54.0		 4awuA-5epdA:
46.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 6 THR A  27
TYR A  68
HIS A 176
TYR A 181
 None
 0.74A 4df2A-5epdA:
44.5		 4df2A-5epdA:
33.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 6 PRO A  25
ARG A 228
GLY A 177
ALA A  58
 None
 1.04A 4g0uA-5epdA:
undetectable		 4g0uA-5epdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 5 HIS A 103
GLN A 185
ILE A 107
TYR A 181
 None
 1.45A 5fuqA-5epdA:
undetectable
5fuqB-5epdA:
undetectable		 5fuqA-5epdA:
21.91
5fuqB-5epdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 12 ILE A  97
LEU A  17
GLY A 172
PHE A 170
ILE A  55
 None
 0.96A 5j7wC-5epdA:
undetectable		 5j7wC-5epdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 12 ILE A  97
LEU A  17
GLY A 172
PHE A 170
ILE A  55
 None
 1.01A 5j7wD-5epdA:
undetectable		 5j7wD-5epdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		4 / 6 GLU A 266
PHE A 287
THR A 290
TYR A 291
 None
 1.13A 5lrbA-5epdA:
undetectable		 5lrbA-5epdA:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 8 THR A  27
TRP A 102
HIS A 176
ASN A 179
TYR A 181
 None
 0.27A 5v4vA-5epdA:
47.2		 5v4vA-5epdA:
37.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 8 THR A  27
TRP A 102
HIS A 176
ASN A 179
TYR A 181
 None
 0.26A 5v4vB-5epdA:
47.2		 5v4vB-5epdA:
37.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 12 ALA A  18
LEU A 313
ILE A 314
VAL A 327
PHE A 320
 None
 1.12A 5vlmE-5epdA:
undetectable		 5vlmE-5epdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5epd GLYCEROL TRINITRATE
REDUCTASE
(Agrobacterium
tumefaciens) 		5 / 12 ILE A  97
LEU A  17
GLY A 172
PHE A 170
ILE A  55
 None
 1.05A 6qxsB-5epdA:
undetectable		 6qxsB-5epdA:
21.07