SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5epe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 LEU A  25
GLY A  29
VAL A  40
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 0.91A 1akdA-5epeA:
undetectable		 1akdA-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 4 GLY A  97
ASP A  94
GLY A  44
THR A  63
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.6A)
None
 0.62A 1hxbB-5epeA:
undetectable		 1hxbB-5epeA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 LEU A  25
GLY A  29
VAL A  40
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 0.88A 1phgA-5epeA:
undetectable		 1phgA-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 LEU A 125
THR A 124
ALA A 127
LEU A  41
ILE A 115
 None
None
None
None
SAH  A 301 (-4.7A)
 0.92A 1qknA-5epeA:
undetectable		 1qknA-5epeA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 7 LEU A  25
GLY A  29
VAL A  40
ASP A  42
 None
None
None
SAH  A 301 ( 4.5A)
 0.97A 1t88A-5epeA:
undetectable		 1t88A-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 LEU A  25
GLY A  29
VAL A  40
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 0.94A 2a1nA-5epeA:
undetectable		 2a1nA-5epeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 5 LEU A 186
GLY A 111
PRO A  19
ALA A 187
 None
SAH  A 301 (-4.9A)
None
None
 0.96A 2aohA-5epeA:
undetectable		 2aohA-5epeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  25
GLY A  29
VAL A  40
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 0.96A 2cp4A-5epeA:
undetectable		 2cp4A-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
ASP A  94
VAL A 110
GLY A 111
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.9A)
 0.52A 2qe6A-5epeA:
8.0		 2qe6A-5epeA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
ASP A  94
VAL A 110
GLY A 111
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.9A)
 0.52A 2qe6B-5epeA:
8.8		 2qe6B-5epeA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 MET A 184
LEU A  32
LEU A  34
PRO A  19
THR A  27
 None
 1.11A 3dcjA-5epeA:
undetectable
3dcjB-5epeA:
undetectable		 3dcjA-5epeA:
26.36
3dcjB-5epeA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 GLY A  44
GLY A  46
ILE A  65
ASP A  94
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.6A)
 0.71A 3dxyA-5epeA:
9.2		 3dxyA-5epeA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 TRP A 240
MET A  50
LEU A  51
GLY A  44
ALA A 108
 None
None
None
SAH  A 301 (-3.6A)
None
 1.19A 3i5uA-5epeA:
12.5		 3i5uA-5epeA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 TRP A 240
MET A  50
LEU A  51
GLY A  44
ALA A 108
 None
None
None
SAH  A 301 (-3.6A)
None
 1.16A 3i5uB-5epeA:
12.3		 3i5uB-5epeA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 4 GLY A  97
ASP A  94
GLY A  44
THR A  63
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.6A)
None
 0.64A 3k4vC-5epeA:
undetectable		 3k4vC-5epeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A 139
GLY A  44
PHE A  71
SER A  68
ALA A 112
 None
SAH  A 301 (-3.6A)
SAH  A 301 (-4.7A)
SAH  A 301 (-4.8A)
SAH  A 301 ( 3.7A)
 1.06A 3kkzB-5epeA:
23.6		 3kkzB-5epeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.73A 3lxiA-5epeA:
undetectable		 3lxiA-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 LEU A  25
LEU A  28
GLY A  29
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.18A 3lxiB-5epeA:
undetectable		 3lxiB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.76A 3lxiB-5epeA:
undetectable		 3lxiB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		3 / 3 GLY A  46
ASP A  66
ASP A  94
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.38A 3ou7C-5epeA:
11.6		 3ou7C-5epeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 9 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.71A 4c9kB-5epeA:
undetectable		 4c9kB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.68A 4c9lA-5epeA:
undetectable		 4c9lA-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.69A 4c9lB-5epeA:
undetectable		 4c9lB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  25
LEU A  28
GLY A  29
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.10A 4c9nB-5epeA:
undetectable		 4c9nB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.68A 4c9nB-5epeA:
undetectable		 4c9nB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  28
LEU A  32
GLY A  29
ASP A  42
VAL A  40
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.34A 4c9nB-5epeA:
undetectable		 4c9nB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.66A 4c9oA-5epeA:
undetectable		 4c9oA-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.64A 4c9oB-5epeA:
undetectable		 4c9oB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 9 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.74A 4c9pA-5epeA:
undetectable		 4c9pA-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  25
LEU A  28
GLY A  29
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.20A 4c9pB-5epeA:
undetectable		 4c9pB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.78A 4c9pB-5epeA:
undetectable		 4c9pB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 7 LEU A  25
VAL A  40
ASP A  42
VAL A 106
 None
None
SAH  A 301 ( 4.5A)
None
 0.98A 4cp4A-5epeA:
undetectable		 4cp4A-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 4 LEU A  67
ALA A  95
ILE A  65
LYS A   1
 SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
None
None
 1.17A 4eixA-5epeA:
undetectable		 4eixA-5epeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
LEU A  67
SER A  68
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.6A)
 0.52A 4htfA-5epeA:
13.0		 4htfA-5epeA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
LEU A  67
SER A  68
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.6A)
 0.49A 4htfB-5epeA:
12.9		 4htfB-5epeA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
ASP A  66
ASP A  94
ALA A 112
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
 0.35A 4iv8A-5epeA:
15.7		 4iv8A-5epeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
ASP A  66
ASP A  94
ALA A 112
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
 0.37A 4iv8B-5epeA:
17.3		 4iv8B-5epeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		6 / 12 GLY A  44
GLY A  46
LEU A  67
SER A  68
ASP A  94
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.6A)
 0.72A 4krhA-5epeA:
17.8		 4krhA-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
LEU A  67
SER A  68
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.6A)
 0.66A 4krhB-5epeA:
17.5		 4krhB-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 8 LEU A  25
VAL A  40
ASP A  42
VAL A 106
 None
None
SAH  A 301 ( 4.5A)
None
 1.01A 4l4bA-5epeA:
undetectable		 4l4bA-5epeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 ASP A  42
GLY A  44
ASP A  66
LEU A  67
ASP A  94
 SAH  A 301 ( 4.5A)
SAH  A 301 (-3.6A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.81A 4pghB-5epeA:
9.6		 4pghB-5epeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
GLY A  48
LEU A  67
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.94A 4uciA-5epeA:
5.7		 4uciA-5epeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
LEU A  67
ALA A  95
ALA A 112
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
 1.01A 4uciA-5epeA:
5.7		 4uciA-5epeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
GLY A  48
LEU A  67
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.91A 4uciB-5epeA:
6.0		 4uciB-5epeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
LEU A  67
ALA A  95
ALA A 112
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
 0.98A 4uciB-5epeA:
6.0		 4uciB-5epeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
GLY A  46
GLY A  48
LEU A  67
ALA A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
 0.94A 4uckA-5epeA:
4.0		 4uckA-5epeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
ASP A  66
LEU A  67
SER A  68
ILE A 115
 SAH  A 301 (-3.6A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-4.7A)
 0.83A 5dpdB-5epeA:
8.2		 5dpdB-5epeA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 6 SER A  47
ALA A  75
HIS A  17
LEU A  70
 None
None
SAH  A 301 (-4.5A)
None
 1.09A 5dzkB-5epeA:
undetectable
5dzkP-5epeA:
undetectable		 5dzkB-5epeA:
23.13
5dzkP-5epeA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 7 SER A  47
ALA A  75
HIS A  17
LEU A  70
 None
None
SAH  A 301 (-4.5A)
None
 1.03A 5dzkD-5epeA:
undetectable
5dzkR-5epeA:
undetectable		 5dzkD-5epeA:
23.13
5dzkR-5epeA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 4 ASP A  42
GLY A  46
ASP A  66
ASP A  94
 SAH  A 301 ( 4.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.49A 5e72A-5epeA:
12.8		 5e72A-5epeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 THR A 122
GLY A 118
PRO A 141
GLY A 241
PHE A  20
 None
 1.09A 5tuiB-5epeA:
undetectable		 5tuiB-5epeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  44
VAL A 110
GLY A  48
GLY A  46
ALA A  79
 SAH  A 301 (-3.6A)
SAH  A 301 (-4.2A)
None
SAH  A 301 (-3.4A)
None
 0.84A 5x7fA-5epeA:
11.3		 5x7fA-5epeA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		4 / 8 LEU A  25
VAL A  40
ASP A  42
VAL A 106
 None
None
SAH  A 301 ( 4.5A)
None
 0.99A 6cp4A-5epeA:
undetectable		 6cp4A-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5epe SAM-DEPENDENT
METHYLTRANSFERASE
(Thiobacillus
denitrificans) 		5 / 11 GLY A  44
GLY A  46
ASP A  66
LEU A  67
ASP A  94
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.78A 6i5zD-5epeA:
9.6		 6i5zD-5epeA:
19.44