SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5epo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 12 ILE A 165
VAL A 121
ALA A  23
SER A  22
SER A  13
 None
None
None
None
NAP  A 301 (-3.0A)
 1.32A 1nbhA-5epoA:
7.6		 1nbhA-5epoA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 12 ILE A 165
VAL A 121
ALA A  23
SER A  22
SER A  13
 None
None
None
None
NAP  A 301 (-3.0A)
 1.34A 1nbhC-5epoA:
6.7		 1nbhC-5epoA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 12 ILE A 165
VAL A 121
ALA A  23
SER A  22
SER A  13
 None
None
None
None
NAP  A 301 (-3.0A)
 1.33A 1nbhD-5epoA:
3.5		 1nbhD-5epoA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 10 ARG A 112
THR A 107
GLY A 105
THR A  94
GLU A 109
 None
 1.29A 1z35A-5epoA:
undetectable		 1z35A-5epoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		4 / 4 ASN A  63
ALA A  37
ARG A  38
TYR A  91
 NAP  A 301 (-3.4A)
None
NAP  A 301 (-3.2A)
NAP  A 301 (-4.9A)
 1.30A 2ak1H-5epoA:
undetectable		 2ak1H-5epoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		4 / 6 ILE A 146
PHE A 208
GLY A 248
GLY A 247
 None
TUD  A 302 ( 4.6A)
None
None
 0.80A 2qx6A-5epoA:
4.0
2qx6B-5epoA:
4.1		 2qx6A-5epoA:
21.32
2qx6B-5epoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 9 ALA A  27
GLY A  30
GLY A  55
ILE A  50
LYS A   2
 None
 0.98A 2v7bA-5epoA:
5.0		 2v7bA-5epoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 9 ALA A  27
GLY A  30
GLY A  55
ILE A  50
LYS A   2
 None
 0.97A 2v7bB-5epoA:
3.8		 2v7bB-5epoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 11 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
 NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
 1.25A 2y7kA-5epoA:
undetectable		 2y7kA-5epoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 12 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
 NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
 1.32A 2y7kC-5epoA:
undetectable		 2y7kC-5epoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 10 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
 NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
 1.29A 2y7pA-5epoA:
undetectable		 2y7pA-5epoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 10 THR A 193
ILE A 191
GLY A 192
GLY A  17
PRO A 188
 NAP  A 301 (-2.9A)
NAP  A 301 (-3.9A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-3.7A)
 1.36A 2y7wB-5epoA:
undetectable		 2y7wB-5epoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		5 / 12 ALA A 224
LEU A 228
LEU A   4
ILE A 191
GLY A  17
 None
None
None
NAP  A 301 (-3.9A)
NAP  A 301 (-3.3A)
 1.07A 3ozwB-5epoA:
5.8		 3ozwB-5epoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		4 / 8 ILE A  50
ASP A  49
VAL A  11
GLY A  19
 None
 0.73A 4acbC-5epoA:
4.4		 4acbC-5epoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		3 / 3 VAL A  96
PHE A 204
ARG A 205
 None
TUD  A 302 (-4.8A)
None
 0.97A 4xr4B-5epoA:
9.4		 4xr4B-5epoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		3 / 3 ASP A  99
ARG A 155
TYR A 158
 None
TUD  A 302 (-4.2A)
TUD  A 302 ( 4.5A)
 1.02A 5a7mA-5epoA:
5.5		 5a7mA-5epoA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		3 / 3 ASP A  99
ARG A 155
TYR A 158
 None
TUD  A 302 (-4.2A)
TUD  A 302 ( 4.5A)
 1.04A 5a7mB-5epoA:
5.4		 5a7mB-5epoA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		4 / 7 VAL A  77
GLU A  81
ASN A  89
ILE A 140
 None
 1.10A 5jh7C-5epoA:
6.1		 5jh7C-5epoA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE
(Clostridium
sardiniense) 		4 / 6 ILE A 223
VAL A  88
TYR A 230
VAL A 227
 None
 1.00A 5jwaH-5epoA:
6.3		 5jwaH-5epoA:
18.39