SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  54
GLU A  47
ASN A  55
 FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-3.8A)
 0.70A 1zq9A-5eqdA:
undetectable		 1zq9A-5eqdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A  76
VAL A  87
TRP A 216
 None
 0.83A 2cc8A-5eqdA:
undetectable		 2cc8A-5eqdA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A  76
VAL A  87
TRP A 216
 None
 0.83A 2ccbA-5eqdA:
undetectable		 2ccbA-5eqdA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 239
ARG A 242
ARG A 238
 None
 0.86A 2j9dA-5eqdA:
undetectable
2j9dC-5eqdA:
undetectable		 2j9dA-5eqdA:
16.58
2j9dC-5eqdA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 HIS A  74
HIS A 303
ARG A 301
TYR A 337
 FAD  A 501 (-3.7A)
None
None
None
 1.34A 2vmyA-5eqdA:
undetectable
2vmyB-5eqdA:
undetectable		 2vmyA-5eqdA:
23.28
2vmyB-5eqdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A  76
VAL A  87
TRP A 216
 None
 0.83A 2vx9A-5eqdA:
undetectable		 2vx9A-5eqdA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 279
THR A 281
ARG A 323
PHE A 284
 None
None
NO3  A 505 (-4.2A)
None
 1.10A 2wm3A-5eqdA:
2.5		 2wm3A-5eqdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A  23
ILE A  46
GLU A  47
HIS A  51
ASP A 233
 FAD  A 501 (-3.1A)
None
FAD  A 501 (-2.7A)
None
FAD  A 501 (-3.6A)
 0.97A 3dxyA-5eqdA:
3.9		 3dxyA-5eqdA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  25
GLY A  23
ALA A  56
THR A 214
LEU A 217
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.1A)
FAD  A 501 ( 4.4A)
None
None
 1.00A 3p2kA-5eqdA:
3.2		 3p2kA-5eqdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  25
GLY A  23
ALA A  56
THR A 214
LEU A 217
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.1A)
FAD  A 501 ( 4.4A)
None
None
 0.91A 3p2kB-5eqdA:
undetectable		 3p2kB-5eqdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 218
LEU A 217
HIS A  51
GLY A  53
 None
 1.27A 3pp1A-5eqdA:
undetectable		 3pp1A-5eqdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 TYR A 194
THR A 195
PHE A 196
LEU A 117
 None
 1.34A 3qelC-5eqdA:
3.3		 3qelC-5eqdA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 MET A 378
PHE A  26
ASN A  55
GLY A  25
GLY A 212
 FAD  A 501 (-4.1A)
FAD  A 501 (-4.7A)
FAD  A 501 (-3.8A)
FAD  A 501 (-3.3A)
NO3  A 502 (-3.2A)
 1.32A 4a6nB-5eqdA:
12.0		 4a6nB-5eqdA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A 261
ASP A 233
ASP A 236
GLU A 358
 None
FAD  A 501 (-3.6A)
None
None
 0.90A 4feuD-5eqdA:
undetectable		 4feuD-5eqdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 371
TYR A 259
THR A 253
GLY A  23
PHE A 235
 None
None
FAD  A 501 (-4.5A)
FAD  A 501 (-3.1A)
FAD  A 501 (-4.6A)
 1.01A 5d4uA-5eqdA:
undetectable		 5d4uA-5eqdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 371
TYR A 259
THR A 253
GLY A  23
PHE A 235
 None
None
FAD  A 501 (-4.5A)
FAD  A 501 (-3.1A)
FAD  A 501 (-4.6A)
 0.98A 5d4uB-5eqdA:
2.5		 5d4uB-5eqdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A  23
GLY A 254
PRO A 255
GLY A 371
 FAD  A 501 (-3.1A)
FAD  A 501 (-3.6A)
FAD  A 501 ( 4.9A)
None
 0.70A 6ag0C-5eqdA:
undetectable		 6ag0C-5eqdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 TYR A 170
GLU A 324
TYR A  96
HIS A 303
 None
 1.27A 6ep4A-5eqdA:
undetectable		 6ep4A-5eqdA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 5eqd UDP-GALACTOPYRANOSE
MUTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 TYR A 337
GLU A 324
TYR A  96
HIS A 303
 None
 1.35A 6ep4A-5eqdA:
undetectable		 6ep4A-5eqdA:
11.89