SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		3 / 3 MET A 364
LEU A 367
SER A 368
 None
 0.53A 1ee2A-5eqiA:
undetectable		 1ee2A-5eqiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 8 CYH A 207
VAL A 203
GLY A  17
GLY A  18
 None
 0.73A 1ekjE-5eqiA:
undetectable
1ekjF-5eqiA:
undetectable		 1ekjE-5eqiA:
16.57
1ekjF-5eqiA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 372
ALA A 309
LEU A 355
PRO A 431
THR A 310
 None
 1.15A 1jolB-5eqiA:
undetectable		 1jolB-5eqiA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 4 THR A 158
LEU A 162
VAL A 165
LEU A 169
 None
 0.80A 1mz9D-5eqiA:
undetectable		 1mz9D-5eqiA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 278
LEU A 341
ILE A 287
GLY A 286
LEU A 284
 None
 1.27A 2j7xA-5eqiA:
undetectable		 2j7xA-5eqiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 5 LEU A 188
GLY A 111
ILE A 193
ILE A 192
 None
 0.73A 2q9rA-5eqiA:
undetectable		 2q9rA-5eqiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 PHE A  26
PHE A 291
GLY A  31
ILE A 164
PHE A 379
 None
5RH  A 501 ( 4.9A)
None
5RH  A 501 (-4.3A)
5RH  A 501 ( 4.5A)
 1.43A 2zznB-5eqiA:
undetectable		 2zznB-5eqiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 4 GLY A  79
GLY A  76
GLY A 130
GLY A 134
 None
 0.67A 3bogD-5eqiA:
undetectable		 3bogD-5eqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A  12
LEU A 215
SER A 148
GLY A 145
GLU A 146
 None
 1.08A 3g2oB-5eqiA:
undetectable		 3g2oB-5eqiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 11 TYR A 293
GLY A 314
SER A 313
PHE A 373
ALA A 309
 None
 1.12A 3sufC-5eqiA:
undetectable		 3sufC-5eqiA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 7 PHE A  72
PHE A  26
GLY A 134
THR A 137
 None
None
None
5RH  A 501 (-2.9A)
 1.01A 4ejjB-5eqiA:
undetectable		 4ejjB-5eqiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		3 / 3 PHE A 389
VAL A 328
GLU A 329
 None
 0.78A 4fvqA-5eqiA:
undetectable		 4fvqA-5eqiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 168
GLY A 312
GLY A 314
ILE A 372
ILE A 369
 None
 1.11A 4iv0B-5eqiA:
undetectable		 4iv0B-5eqiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 168
GLY A 312
GLY A 314
ILE A 372
ILE A 369
 None
 1.13A 4mwzA-5eqiA:
undetectable		 4mwzA-5eqiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		3 / 3 GLU A 380
ALA A 377
PHE A 379
 5RH  A 501 ( 3.6A)
None
5RH  A 501 ( 4.5A)
 0.65A 4v1fC-5eqiA:
undetectable		 4v1fC-5eqiA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 4 GLY A  27
VAL A  32
PHE A 194
ILE A 192
 None
 1.11A 4xv2B-5eqiA:
undetectable		 4xv2B-5eqiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		3 / 3 SER A 368
GLU A 426
GLU A  41
 None
 0.81A 4ymgB-5eqiA:
undetectable		 4ymgB-5eqiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 5 ARG A 269
GLN A 270
PRO A 271
ILE A 272
 None
 1.40A 5ki6A-5eqiA:
undetectable		 5ki6A-5eqiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A  33
TYR A 292
PHE A 416
VAL A 418
ILE A 129
 None
 1.12A 5n0xA-5eqiA:
undetectable		 5n0xA-5eqiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		5 / 12 VAL A 165
GLY A 167
ALA A 171
ASN A 317
VAL A 290
 None
 1.12A 6bqgA-5eqiA:
2.1		 6bqgA-5eqiA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1
(Homo
sapiens) 		4 / 8 TRP A 388
GLY A 138
SER A  80
PHE A  26
 5RH  A 501 (-3.1A)
None
5RH  A 501 (-2.7A)
None
 1.04A 6eqpA-5eqiA:
undetectable		 6eqpA-5eqiA:
9.71