SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		5 / 10 GLY A 103
LEU A  55
VAL A  60
ASP A  54
ASN A  46
 None
 1.28A 1fpqA-5eqnA:
2.0		 1fpqA-5eqnA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.10A 1p6kA-5eqnA:
undetectable		 1p6kA-5eqnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.18A 1p6kB-5eqnA:
undetectable		 1p6kB-5eqnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.07A 1rs6A-5eqnA:
undetectable		 1rs6A-5eqnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.18A 1rs6B-5eqnA:
undetectable		 1rs6B-5eqnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		5 / 12 MET A 278
LEU A  62
ILE A  38
VAL A  88
LEU A 107
 None
 1.34A 1wsvA-5eqnA:
undetectable		 1wsvA-5eqnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		5 / 12 MET A 278
LEU A  62
ILE A  38
VAL A  88
LEU A 107
 None
 1.28A 1wsvB-5eqnA:
undetectable		 1wsvB-5eqnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.08A 1zzqA-5eqnA:
undetectable		 1zzqA-5eqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.19A 1zzqB-5eqnA:
undetectable		 1zzqB-5eqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 0.89A 1zzuA-5eqnA:
1.2		 1zzuA-5eqnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.17A 1zzuB-5eqnA:
undetectable		 1zzuB-5eqnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 5 LEU A  85
GLY A  33
PRO A  89
VAL A  88
 None
 0.88A 2aojA-5eqnA:
undetectable		 2aojA-5eqnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.09A 3n62A-5eqnA:
1.1		 3n62A-5eqnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.05A 3n62B-5eqnA:
undetectable		 3n62B-5eqnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 0.99A 3n66B-5eqnA:
1.1		 3n66B-5eqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		6 / 12 LEU A  30
VAL A  69
MET A  34
GLU A  37
ILE A  38
ALA A  41
 None
 1.17A 4ltwA-5eqnA:
undetectable		 4ltwA-5eqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		3 / 3 TRP A  15
MET A 177
ASN A 181
 None
 1.24A 5uc1B-5eqnA:
undetectable		 5uc1B-5eqnA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		3 / 3 TRP A  15
MET A 177
ASN A 181
 None
 1.18A 5uc1A-5eqnA:
undetectable		 5uc1A-5eqnA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.08A 5vunA-5eqnA:
undetectable		 5vunA-5eqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.02A 5vunB-5eqnA:
undetectable		 5vunB-5eqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.01A 5vuoB-5eqnA:
undetectable		 5vuoB-5eqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 8 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.02A 6auuB-5eqnA:
undetectable		 6auuB-5eqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 5eqn FRBJ
(Streptomyces
rubellomurinus) 		4 / 5 HIS A 150
ASP A 152
HIS A 288
ARG A 309
 MG  A 401 (-3.6A)
MG  A 401 (-3.5A)
MG  A 401 (-3.8A)
MG  A 401 (-4.7A)
 0.80A 6dchA-5eqnA:
13.6		 6dchA-5eqnA:
22.70