SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 8 ARG A1062
THR A1054
GLY A1060
THR A1076
 None
None
SO4  A1201 ( 4.0A)
None
 0.96A 2f9wA-5eqqA:
undetectable
2f9wB-5eqqA:
undetectable		 2f9wA-5eqqA:
22.51
2f9wB-5eqqA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		7 / 12 ARG A1123
LEU A1135
GLY A1137
PHE A1154
ARG A1155
ALA A1157
VAL A1158
 5RS  A1203 ( 3.3A)
5RS  A1203 (-4.2A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
 1.12A 2oc8A-5eqqA:
29.9		 2oc8A-5eqqA:
86.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
HIS A1057
ARG A1123
ILE A1132
LEU A1135
GLY A1137
PHE A1154
ALA A1156
ALA A1157
VAL A1158
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
 0.77A 2oc8A-5eqqA:
29.9		 2oc8A-5eqqA:
86.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		3 / 3 ARG A1155
ASN A1049
THR A1178
 5RS  A1203 (-4.8A)
None
None
 0.85A 2q63A-5eqqA:
undetectable		 2q63A-5eqqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 12 GLY A1050
ALA A1087
ILE A1064
GLY A1084
VAL A1033
 None
 0.99A 3cyxA-5eqqA:
undetectable		 3cyxA-5eqqA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
CYH A1159
ASP A1168
 5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.5A)
5RS  A1203 ( 4.0A)
 0.37A 3keeA-5eqqA:
31.0		 3keeA-5eqqA:
80.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		9 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.37A 3keeB-5eqqA:
30.8		 3keeB-5eqqA:
80.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		3 / 3 PHE A1043
TYR A1056
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
 0.26A 3keeB-5eqqA:
30.8		 3keeB-5eqqA:
80.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		9 / 12 HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
ASP A1168
 5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.0A)
 0.23A 3keeC-5eqqA:
30.7		 3keeC-5eqqA:
80.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 4 GLN A1041
PHE A1043
TYR A1056
LEU A1135
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
 0.50A 3keeC-5eqqA:
30.7		 3keeC-5eqqA:
80.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
ASP A1168
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.0A)
 0.37A 3keeD-5eqqA:
31.1		 3keeD-5eqqA:
80.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ARG A1123
LYS A1136
GLY A1137
ALA A1139
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.41A 3sudA-5eqqA:
36.0		 3sudA-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 4 PHE A1043
TYR A1056
ILE A1132
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
 0.37A 3sudA-5eqqA:
36.0		 3sudA-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 GLN A1041
PHE A1043
TYR A1056
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
ALA A1139
PHE A1154
ALA A1156
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
 0.35A 3sudB-5eqqA:
35.8		 3sudB-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		12 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ARG A1123
ILE A1132
GLY A1137
ALA A1139
PHE A1154
ARG A1155
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.65A 3sudC-5eqqA:
34.6		 3sudC-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 4 PHE A1043
TYR A1056
LEU A1135
LYS A1136
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.32A 3sudC-5eqqA:
34.6		 3sudC-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 GLN A1041
HIS A1057
GLY A1058
VAL A1078
ASP A1081
GLY A1137
ALA A1139
PHE A1154
ALA A1156
ALA A1157
ASP A1168
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.0A)
 0.30A 3sudD-5eqqA:
34.5		 3sudD-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 5 PHE A1043
TYR A1056
LEU A1135
LYS A1136
ARG A1155
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
5RS  A1203 (-4.8A)
 0.31A 3sudD-5eqqA:
34.5		 3sudD-5eqqA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		9 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.33A 3sueA-5eqqA:
35.7		 3sueA-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 4 PHE A1043
TYR A1056
ARG A1123
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-4.2A)
 0.38A 3sueA-5eqqA:
35.7		 3sueA-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ARG A1123
LYS A1136
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.39A 3sueB-5eqqA:
12.5		 3sueB-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		3 / 3 PHE A1043
TYR A1056
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
 0.11A 3sueB-5eqqA:
12.5		 3sueB-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
HIS A1057
GLY A1058
VAL A1078
ASP A1081
GLY A1137
PHE A1154
ALA A1156
ALA A1157
ASP A1168
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.0A)
 0.67A 3sueC-5eqqA:
34.3		 3sueC-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 5 PHE A1043
TYR A1056
ILE A1132
LEU A1135
LYS A1136
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.63A 3sueC-5eqqA:
34.3		 3sueC-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		9 / 12 GLN A1041
PHE A1043
HIS A1057
GLY A1058
ASP A1081
ARG A1123
GLY A1137
PHE A1154
ALA A1156
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
 0.29A 3sueD-5eqqA:
33.9		 3sueD-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		3 / 3 TYR A1056
LEU A1135
LYS A1136
 SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.44A 3sueD-5eqqA:
33.9		 3sueD-5eqqA:
93.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ARG A1123
LEU A1135
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-4.2A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.40A 3sufA-5eqqA:
35.5		 3sufA-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 GLN A1041
PHE A1043
VAL A1055
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
None
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.30A 3sufB-5eqqA:
35.1		 3sufB-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		3 / 3 TYR A1056
LEU A1135
ARG A1155
 SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.30A 3sufB-5eqqA:
35.1		 3sufB-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 5 SER A1128
ARG A1130
PRO A1131
VAL A1163
 None
 0.53A 3sufC-5eqqA:
33.9		 3sufC-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 11 GLN A1041
PHE A1043
TYR A1056
HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.32A 3sufC-5eqqA:
33.9		 3sufC-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 VAL A1055
HIS A1057
GLY A1058
VAL A1078
ASP A1081
ILE A1132
GLY A1137
PHE A1154
ALA A1156
ALA A1157
CYH A1159
 None
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.5A)
 0.51A 3sufD-5eqqA:
32.7		 3sufD-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 5 GLN A1041
PHE A1043
TYR A1056
LYS A1136
ARG A1155
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.8A)
5RS  A1203 (-4.8A)
 0.46A 3sufD-5eqqA:
32.7		 3sufD-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		8 / 12 HIS A1057
GLY A1058
ARG A1123
GLY A1137
ALA A1139
PHE A1154
ALA A1157
ASP A1168
 5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.0A)
 0.73A 3sugA-5eqqA:
36.4		 3sugA-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		8 / 12 HIS A1057
GLY A1058
ARG A1123
GLY A1137
ALA A1139
PHE A1154
ARG A1155
ASP A1168
 5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 ( 4.0A)
 1.03A 3sugA-5eqqA:
36.4		 3sugA-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		9 / 12 HIS A1057
GLY A1058
VAL A1078
ASP A1081
ARG A1123
GLY A1137
ALA A1139
PHE A1154
ALA A1157
 5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-3.5A)
 0.41A 3sugA-5eqqA:
36.4		 3sugA-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		9 / 12 HIS A1057
GLY A1058
VAL A1078
ASP A1081
ARG A1123
GLY A1137
ALA A1139
PHE A1154
ARG A1155
 5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
 0.87A 3sugA-5eqqA:
36.4		 3sugA-5eqqA:
94.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 5 GLN A1041
PHE A1043
TYR A1056
LEU A1135
LYS A1136
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.33A 3sugA-5eqqA:
36.4		 3sugA-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 12 VAL A1083
GLY A1060
ARG A1062
THR A1038
GLN A1073
 None
SO4  A1201 ( 4.0A)
None
None
None
 1.26A 4o5fA-5eqqA:
undetectable
4o5fB-5eqqA:
undetectable		 4o5fA-5eqqA:
22.09
4o5fB-5eqqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 12 GLN A1073
VAL A1083
GLY A1060
ARG A1062
THR A1038
 None
None
SO4  A1201 ( 4.0A)
None
None
 1.27A 4o5fA-5eqqA:
undetectable
4o5fB-5eqqA:
undetectable		 4o5fA-5eqqA:
22.09
4o5fB-5eqqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 11 GLY A1050
ALA A1087
ILE A1064
GLY A1084
VAL A1033
 None
 0.98A 4qgiA-5eqqA:
undetectable		 4qgiA-5eqqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		3 / 3 GLY A1141
PRO A1142
ALA A1150
 None
 0.51A 4qn9B-5eqqA:
undetectable		 4qn9B-5eqqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 12 VAL A1083
GLY A1060
ARG A1062
THR A1038
GLN A1073
 None
SO4  A1201 ( 4.0A)
None
None
None
 1.26A 5b8hA-5eqqA:
undetectable
5b8hB-5eqqA:
undetectable		 5b8hA-5eqqA:
21.45
5b8hB-5eqqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 12 GLN A1073
VAL A1083
GLY A1060
ARG A1062
THR A1038
 None
None
SO4  A1201 ( 4.0A)
None
None
 1.24A 5b8hA-5eqqA:
undetectable
5b8hB-5eqqA:
undetectable		 5b8hA-5eqqA:
21.45
5b8hB-5eqqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_2
(BETA-LACTAMASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		4 / 4 CYH A1145
ILE A1048
PRO A1142
THR A1098
 ZN  A1202 (-2.3A)
None
None
None
 1.28A 6b68D-5eqqA:
0.0		 6b68D-5eqqA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 GLN A1041
PHE A1043
HIS A1057
GLY A1058
VAL A1078
ARG A1123
ILE A1132
LEU A1135
GLY A1137
PHE A1154
ALA A1156
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
 0.35A 6c2mA-5eqqA:
35.6		 6c2mA-5eqqA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		6 / 9 VAL A1055
ASP A1081
ARG A1155
ALA A1157
VAL A1158
ASP A1168
 None
5RS  A1203 (-3.5A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
5RS  A1203 ( 4.0A)
 0.25A 6c2mA-5eqqA:
35.6		 6c2mA-5eqqA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
PHE A1043
HIS A1057
GLY A1058
VAL A1078
ARG A1123
ILE A1132
GLY A1137
PHE A1154
ALA A1156
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
 0.39A 6c2mB-5eqqA:
35.9		 6c2mB-5eqqA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		7 / 9 VAL A1055
ASP A1081
LEU A1135
ARG A1155
ALA A1157
VAL A1158
ASP A1168
 None
5RS  A1203 (-3.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
5RS  A1203 ( 4.0A)
 0.27A 6c2mB-5eqqA:
35.9		 6c2mB-5eqqA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		10 / 12 GLN A1041
HIS A1057
VAL A1078
ASP A1081
ARG A1123
GLY A1137
PHE A1154
ALA A1156
ALA A1157
VAL A1158
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
 0.33A 6c2mC-5eqqA:
35.5		 6c2mC-5eqqA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		8 / 9 PHE A1043
VAL A1055
GLY A1058
ILE A1132
LEU A1135
LYS A1136
ARG A1155
ASP A1168
 5RS  A1203 (-4.3A)
None
5RS  A1203 ( 2.9A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
5RS  A1203 (-4.8A)
5RS  A1203 ( 4.0A)
 0.52A 6c2mC-5eqqA:
35.5		 6c2mC-5eqqA:
98.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		11 / 12 GLN A1041
HIS A1057
GLY A1058
VAL A1078
ARG A1123
ILE A1132
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.47A 6c2mD-5eqqA:
35.4		 6c2mD-5eqqA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5eqq NS3 PROTEASE
(Hepacivirus
C) 		5 / 12 VAL A 992
SER A 991
LEU A1052
GLY A1060
VAL A1071
 None
None
None
SO4  A1201 ( 4.0A)
None
 1.15A 6drzA-5eqqA:
undetectable		 6drzA-5eqqA:
16.43