SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 212
LEU A 230
LEU A 234
ALA A 250
PHE A 268
 None
 0.96A 1gseA-5eqtA:
undetectable		 1gseA-5eqtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 212
LEU A 230
LEU A 234
ALA A 250
PHE A 268
 None
 0.97A 1gseB-5eqtA:
undetectable		 1gseB-5eqtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 277
PRO A 149
GLY A 150
CYH A 151
 None
ACT  A 402 ( 3.6A)
ADP  A 401 (-3.1A)
None
 0.82A 1h4oB-5eqtA:
undetectable		 1h4oB-5eqtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 277
PRO A 149
GLY A 150
CYH A 151
 None
ACT  A 402 ( 3.6A)
ADP  A 401 (-3.1A)
None
 0.80A 1h4oG-5eqtA:
undetectable		 1h4oG-5eqtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.06A 1iiuA-5eqtA:
undetectable		 1iiuA-5eqtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.06A 1kt5A-5eqtA:
undetectable		 1kt5A-5eqtA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 277
PRO A 149
GLY A 150
CYH A 151
 None
ACT  A 402 ( 3.6A)
ADP  A 401 (-3.1A)
None
 0.82A 1oc3A-5eqtA:
undetectable		 1oc3A-5eqtA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.05A 1rbpA-5eqtA:
undetectable		 1rbpA-5eqtA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.12A 1rlbE-5eqtA:
undetectable		 1rlbE-5eqtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.05A 1rlbF-5eqtA:
undetectable		 1rlbF-5eqtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 7 GLY A 110
GLN A 114
MET A 156
ILE A 285
PRO A 277
 None
None
None
ADP  A 401 (-4.2A)
None
 1.46A 1rxcC-5eqtA:
undetectable		 1rxcC-5eqtA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 155
THR A 154
ALA A 157
LEU A 118
LEU A 115
 ADP  A 401 (-3.8A)
ADP  A 401 (-3.5A)
None
None
None
 1.16A 3hm1A-5eqtA:
undetectable		 3hm1A-5eqtA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 110
GLN A 114
MET A 156
ILE A 285
PRO A 277
 None
None
None
ADP  A 401 (-4.2A)
None
 1.48A 4e1vC-5eqtA:
undetectable		 4e1vC-5eqtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 110
GLN A 114
MET A 156
ILE A 285
PRO A 277
 None
None
None
ADP  A 401 (-4.2A)
None
 1.48A 4e1vD-5eqtA:
undetectable		 4e1vD-5eqtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 110
GLN A 114
MET A 156
ILE A 285
PRO A 277
 None
None
None
ADP  A 401 (-4.2A)
None
 1.45A 4e1vH-5eqtA:
undetectable		 4e1vH-5eqtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 321
ALA A 322
PHE A 325
 None
 0.57A 4v1fA-5eqtA:
undetectable		 4v1fA-5eqtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 321
ALA A 322
PHE A 325
 None
 0.62A 4v1fC-5eqtA:
undetectable		 4v1fC-5eqtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 234
THR A 252
ALA A 250
VAL A 248
ILE A 205
 None
 1.12A 4x1kD-5eqtA:
undetectable		 4x1kD-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 234
LEU A 262
ALA A 250
VAL A 248
ILE A 208
 None
 1.14A 4x1yB-5eqtA:
undetectable		 4x1yB-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 234
LEU A 262
THR A 252
ALA A 250
VAL A 248
 None
 0.88A 4x20D-5eqtA:
undetectable		 4x20D-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 234
THR A 252
ALA A 250
VAL A 248
ILE A 205
 None
 1.11A 4x20D-5eqtA:
undetectable		 4x20D-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 211
GLY A 212
LEU A 176
GLU A 207
VAL A 171
 None
 1.33A 5hw4B-5eqtA:
undetectable		 5hw4B-5eqtA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 211
LEU A 233
MET A 237
LEU A 234
 None
 1.07A 5u4sB-5eqtA:
undetectable		 5u4sB-5eqtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 10 MET A 306
ASP A 299
ILE A 285
PRO A 277
GLY A 281
 None
None
ADP  A 401 (-4.2A)
None
None
 1.34A 5weoA-5eqtA:
undetectable
5weoD-5eqtA:
3.5		 5weoA-5eqtA:
13.83
5weoD-5eqtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 9 MET A 306
ASP A 299
ILE A 285
PRO A 277
GLY A 281
 None
None
ADP  A 401 (-4.2A)
None
None
 1.33A 5weoB-5eqtA:
3.4
5weoC-5eqtA:
undetectable		 5weoB-5eqtA:
13.83
5weoC-5eqtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 285
PRO A 277
GLY A 281
MET A 306
ASP A 299
 ADP  A 401 (-4.2A)
None
None
None
None
 1.34A 5weoA-5eqtA:
undetectable
5weoD-5eqtA:
3.5		 5weoA-5eqtA:
13.83
5weoD-5eqtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Pyrococcus
horikoshii) 		5 / 10 MET A 306
ASP A 299
ILE A 285
PRO A 277
GLY A 281
 None
None
ADP  A 401 (-4.2A)
None
None
 1.21A 6dm0B-5eqtA:
undetectable
6dm0C-5eqtA:
undetectable		 6dm0B-5eqtA:
17.12
6dm0C-5eqtA:
17.12