SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5equ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 5 THR A 146
ASP A 132
HIS A 130
HIS A 207
HIS A 213
 AKG  A 301 ( 4.3A)
FE  A 300 (-2.2A)
FE  A 300 (-3.1A)
AKG  A 301 (-4.2A)
FE  A 300 ( 3.2A)
 1.22A 1ei6A-5equA:
undetectable		 1ei6A-5equA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 8 THR A 146
ASP A 132
HIS A 130
HIS A 207
 AKG  A 301 ( 4.3A)
FE  A 300 (-2.2A)
FE  A 300 (-3.1A)
AKG  A 301 (-4.2A)
 0.99A 1ei6C-5equA:
undetectable		 1ei6C-5equA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 7 LEU A 108
THR A 227
ALA A 229
VAL A 149
 None
 0.63A 1tyrB-5equA:
undetectable		 1tyrB-5equA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 12 MET A 161
HIS A 213
ASP A 132
HIS A 207
SER A 226
 AKG  A 301 ( 3.7A)
FE  A 300 ( 3.2A)
FE  A 300 (-2.2A)
AKG  A 301 (-4.2A)
AKG  A 301 ( 4.9A)
 1.16A 1uobA-5equA:
9.9		 1uobA-5equA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 7 THR A 127
PRO A 126
GLY A 216
THR A 162
 AKG  A 301 (-3.0A)
None
None
None
 1.04A 2vl2B-5equA:
undetectable		 2vl2B-5equA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 10 LEU A 114
THR A 127
HIS A 130
ASP A 132
HIS A 213
 AKG  A 301 (-4.6A)
AKG  A 301 (-3.0A)
FE  A 300 (-3.1A)
FE  A 300 (-2.2A)
FE  A 300 ( 3.2A)
 0.46A 3kcxA-5equA:
8.6		 3kcxA-5equA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5equ SNON,SNON
(Streptomyces
nogalater) 		3 / 3 LYS A 116
ARG A 224
TRP A 148
 AKG  A 301 ( 4.2A)
AKG  A 301 (-2.7A)
AKG  A 301 (-3.9A)
 1.14A 4i90A-5equA:
undetectable		 4i90A-5equA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 8 LEU A 108
THR A 227
ALA A 229
VAL A 149
 None
 0.63A 4ik6B-5equA:
undetectable		 4ik6B-5equA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 7 LEU A 108
THR A 227
ALA A 229
VAL A 149
 None
 0.69A 4ik7A-5equA:
undetectable		 4ik7A-5equA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 8 GLU A 189
HIS A 131
GLY A 182
VAL A 212
ASP A 172
 None
 1.21A 5f8yA-5equA:
undetectable		 5f8yA-5equA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 8 GLU A 189
HIS A 131
GLY A 182
VAL A 212
ASP A 172
 None
 1.37A 5f8yA-5equA:
undetectable		 5f8yA-5equA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 8 GLU A 189
HIS A 131
GLY A 182
VAL A 212
ASP A 172
 None
 1.23A 5f8yB-5equA:
undetectable		 5f8yB-5equA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5equ SNON,SNON
(Streptomyces
nogalater) 		5 / 8 GLU A 189
HIS A 131
GLY A 182
VAL A 212
ASP A 172
 None
 1.31A 5f8yB-5equA:
undetectable		 5f8yB-5equA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 8 GLU A  60
GLY A  81
THR A 227
TYR A  74
 None
None
None
5R6  A 302 (-3.5A)
 0.97A 5flcB-5equA:
undetectable		 5flcB-5equA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 8 GLU A  60
GLY A  81
THR A 227
TYR A  74
 None
None
None
5R6  A 302 (-3.5A)
 0.97A 5flcF-5equA:
undetectable		 5flcF-5equA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5equ SNON,SNON
(Streptomyces
nogalater) 		4 / 5 GLY A 142
THR A 143
GLY A  65
LEU A 246
 None
 0.93A 5jlcA-5equA:
undetectable		 5jlcA-5equA:
18.20