SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5erb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 325
GLY A 238
PHE A 237
GLY A 241
 None
 0.74A 1d0vA-5erbA:
undetectable		 1d0vA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 8 THR A 320
GLY A 325
GLY A 238
GLY A 241
 None
 0.70A 1d0vA-5erbA:
undetectable		 1d0vA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.24A 1ddrB-5erbA:
undetectable		 1ddrB-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.20A 1ddsB-5erbA:
undetectable		 1ddsB-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.15A 1dyiA-5erbA:
undetectable		 1dyiA-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.12A 1dyiB-5erbA:
undetectable		 1dyiB-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ALA A 575
VAL A 577
TRP A 568
 None
 0.99A 1gmkC-5erbA:
undetectable
1gmkD-5erbA:
undetectable		 1gmkC-5erbA:
2.86
1gmkD-5erbA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 325
GLY A 238
PHE A 237
GLY A 241
 None
 0.76A 1jhaA-5erbA:
undetectable		 1jhaA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 8 THR A 320
GLY A 325
GLY A 238
GLY A 241
 None
 0.70A 1jhaA-5erbA:
undetectable		 1jhaA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 9 THR A 320
GLY A 325
GLY A 238
PHE A 237
GLY A 241
 None
 0.90A 1jhyA-5erbA:
undetectable		 1jhyA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.18A 1jolA-5erbA:
undetectable		 1jolA-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.15A 1jolB-5erbA:
undetectable		 1jolB-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
LEU A 372
GLY A 209
GLY A 208
THR A 369
 None
 1.05A 1liiA-5erbA:
undetectable		 1liiA-5erbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
LEU A 372
GLY A 209
GLY A 208
THR A 369
 None
 1.09A 1likA-5erbA:
undetectable		 1likA-5erbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.08A 1rx3A-5erbA:
undetectable		 1rx3A-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.12A 1rx8A-5erbA:
undetectable		 1rx8A-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 9 LEU A 429
LEU A 187
VAL A 297
ALA A 295
LEU A 333
 None
 1.24A 1tbfA-5erbA:
undetectable		 1tbfA-5erbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 6 ARG A  17
ILE A 356
ALA A 366
ALA A 252
 None
 0.97A 1w0gA-5erbA:
undetectable		 1w0gA-5erbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 CYH A 101
TYR A 269
GLY A 251
LEU A  24
SER A 602
 None
 1.11A 2bxeB-5erbA:
undetectable		 2bxeB-5erbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 373
TYR A 269
HIS A 267
ILE A 601
TYR A 490
 None
 1.23A 2efjA-5erbA:
2.4		 2efjA-5erbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.99A 2f81B-5erbA:
undetectable		 2f81B-5erbA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.05A 2hs2B-5erbA:
undetectable		 2hs2B-5erbA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 9 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.91A 2idwB-5erbA:
undetectable		 2idwB-5erbA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.95A 2ienB-5erbA:
undetectable		 2ienB-5erbA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A 208
ALA A 207
GLY A  13
ILE A  14
ILE A 190
 None
 0.96A 2o4sA-5erbA:
undetectable		 2o4sA-5erbA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 6 LEU A 429
SER A 236
PHE A 237
GLU A 316
 None
 1.21A 2vn1B-5erbA:
undetectable		 2vn1B-5erbA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.13A 2zzaA-5erbA:
undetectable		 2zzaA-5erbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.13A 2zzaB-5erbA:
undetectable		 2zzaB-5erbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 6 LEU A 271
GLY A 274
LEU A 258
SER A 259
 None
 0.94A 3aiaA-5erbA:
undetectable		 3aiaA-5erbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.34A 3bexC-5erbA:
undetectable
3bexD-5erbA:
undetectable		 3bexC-5erbA:
18.10
3bexD-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 10 LEU A  24
THR A 369
GLY A 251
THR A 105
ILE A  14
 None
 1.34A 3bexC-5erbA:
undetectable
3bexD-5erbA:
undetectable		 3bexC-5erbA:
18.10
3bexD-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 10 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.33A 3bexE-5erbA:
undetectable
3bexF-5erbA:
undetectable		 3bexE-5erbA:
18.10
3bexF-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A  24
THR A 369
GLY A 251
THR A 105
ILE A  14
 None
 1.34A 3bexE-5erbA:
undetectable
3bexF-5erbA:
undetectable		 3bexE-5erbA:
18.10
3bexF-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.31A 3bf1A-5erbA:
undetectable
3bf1B-5erbA:
undetectable		 3bf1A-5erbA:
18.10
3bf1B-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.35A 3bf1C-5erbA:
undetectable
3bf1D-5erbA:
undetectable		 3bf1C-5erbA:
18.10
3bf1D-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A  24
THR A 369
GLY A 251
THR A 105
ILE A  14
 None
 1.34A 3bf1C-5erbA:
undetectable
3bf1D-5erbA:
undetectable		 3bf1C-5erbA:
18.10
3bf1D-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.31A 3bf1E-5erbA:
undetectable
3bf1F-5erbA:
undetectable		 3bf1E-5erbA:
18.10
3bf1F-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A  24
THR A 369
GLY A 251
THR A 105
ILE A  14
 None
 1.34A 3bf1E-5erbA:
undetectable
3bf1F-5erbA:
undetectable		 3bf1E-5erbA:
18.10
3bf1F-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 9 LEU A 258
SER A 447
ILE A 268
ILE A 441
GLY A 428
 None
 1.00A 3cv9A-5erbA:
undetectable		 3cv9A-5erbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.96A 3d1zB-5erbA:
undetectable		 3d1zB-5erbA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.07A 3d20A-5erbA:
undetectable		 3d20A-5erbA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.13A 3dauA-5erbA:
undetectable		 3dauA-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.00A 3ektD-5erbA:
undetectable		 3ektD-5erbA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 4 ILE A  11
ARG A 497
ILE A  12
THR A 369
 None
 1.20A 3ia4C-5erbA:
undetectable		 3ia4C-5erbA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.99A 3k4vD-5erbA:
undetectable		 3k4vD-5erbA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.03A 3mwsA-5erbA:
undetectable		 3mwsA-5erbA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ASP A 304
GLY A 274
ALA A 305
ILE A 298
ALA A 276
 None
 1.15A 3n3iA-5erbA:
undetectable		 3n3iA-5erbA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 10 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.98A 3nu6B-5erbA:
undetectable		 3nu6B-5erbA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.11A 3ql0A-5erbA:
undetectable		 3ql0A-5erbA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.94A 3s45B-5erbA:
undetectable		 3s45B-5erbA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.99A 3tkwA-5erbA:
undetectable		 3tkwA-5erbA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ALA A 484
LEU A 603
LEU A 502
LEU A 466
ILE A 464
 None
 0.98A 3uvvA-5erbA:
undetectable		 3uvvA-5erbA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 5 HIS A 460
SER A 462
SER A 518
VAL A 517
 None
 1.45A 4a99D-5erbA:
undetectable		 4a99D-5erbA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		6 / 10 GLY A 208
ALA A 207
ILE A 190
ILE A 443
LEU A 372
ILE A  11
 None
 1.14A 4dt8B-5erbA:
undetectable		 4dt8B-5erbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 10 ALA A 207
ILE A 190
ILE A 443
LEU A 372
ILE A  11
 None
 1.10A 4dtaA-5erbA:
undetectable		 4dtaA-5erbA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.02A 4hlaA-5erbA:
undetectable		 4hlaA-5erbA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.00A 4hlaB-5erbA:
undetectable		 4hlaB-5erbA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 580
PHE A 555
ASP A 558
ASP A 560
MET A 561
 None
 1.21A 4j7xF-5erbA:
undetectable		 4j7xF-5erbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 580
PHE A 555
ASP A 558
ASP A 560
MET A 561
 None
 1.29A 4j7xJ-5erbA:
undetectable		 4j7xJ-5erbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 9 THR A 320
GLY A 325
GLY A 238
PHE A 237
GLY A 241
 None
 0.87A 4kqiA-5erbA:
undetectable		 4kqiA-5erbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.29A 4o5fA-5erbA:
undetectable
4o5fB-5erbA:
undetectable		 4o5fA-5erbA:
19.97
4o5fB-5erbA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.16A 4qi9B-5erbA:
undetectable		 4qi9B-5erbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.11A 4qlfA-5erbA:
undetectable		 4qlfA-5erbA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.14A 4qlgA-5erbA:
undetectable		 4qlgA-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ALA A 362
SER A 186
GLY A 208
GLY A  16
TYR A  18
 None
 1.30A 4r29A-5erbA:
undetectable		 4r29A-5erbA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.10A 4rgcA-5erbA:
undetectable		 4rgcA-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 11 LEU A  24
GLY A  13
LEU A 254
ALA A 605
PHE A 206
 None
 1.35A 4wnuC-5erbA:
undetectable		 4wnuC-5erbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.10A 4x5fA-5erbA:
undetectable		 4x5fA-5erbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.10A 4x5fB-5erbA:
undetectable		 4x5fB-5erbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.11A 4x5gA-5erbA:
undetectable		 4x5gA-5erbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.14A 4x5hA-5erbA:
undetectable		 4x5hA-5erbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 373
VAL A 253
ILE A 365
ILE A  11
GLY A 270
 None
 1.02A 4y8wC-5erbA:
undetectable		 4y8wC-5erbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A 251
THR A 105
ILE A  14
LEU A  24
THR A 369
 None
 1.30A 5b8hA-5erbA:
undetectable
5b8hB-5erbA:
undetectable		 5b8hA-5erbA:
20.81
5b8hB-5erbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A  24
THR A 369
GLY A 251
THR A 105
ILE A  14
 None
 1.28A 5b8hA-5erbA:
undetectable
5b8hB-5erbA:
undetectable		 5b8hA-5erbA:
20.81
5b8hB-5erbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 5 THR A 320
GLY A 243
HIS A 385
ASP A 326
 None
 1.18A 5c0oH-5erbA:
undetectable		 5c0oH-5erbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		6 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 441
ILE A 190
 None
 1.20A 5e5jA-5erbA:
undetectable		 5e5jA-5erbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		6 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 441
ILE A 190
 None
 1.27A 5e5kB-5erbA:
undetectable		 5e5kB-5erbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 365
ALA A 189
LEU A 255
ILE A 443
LEU A 372
 None
 1.16A 5e8qB-5erbA:
undetectable		 5e8qB-5erbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 7 VAL A 128
GLU A 203
ALA A 204
LEU A 116
 None
 0.59A 5jq7A-5erbA:
undetectable		 5jq7A-5erbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 1.07A 5t2zA-5erbA:
undetectable		 5t2zA-5erbA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 10 LEU A  97
ILE A 162
GLY A 251
GLY A 208
LEU A  99
 None
 1.12A 5twjB-5erbA:
undetectable		 5twjB-5erbA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 6 ASN A 127
ALA A 126
VAL A 128
ASP A 122
 None
 1.21A 5umd2-5erbA:
undetectable
5umdF-5erbA:
undetectable		 5umd2-5erbA:
11.74
5umdF-5erbA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 SER A 430
GLY A 367
ALA A 366
SER A 185
GLU A 329
 None
 1.45A 5wbvA-5erbA:
undetectable		 5wbvA-5erbA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 SER A 430
GLY A 367
ALA A 366
SER A 185
GLU A 329
 None
 1.45A 5wbvB-5erbA:
undetectable		 5wbvB-5erbA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A 357
GLY A 247
THR A 369
LEU A 373
PHE A  27
 None
 1.09A 5ybbA-5erbA:
undetectable		 5ybbA-5erbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A 325
GLY A 241
ASP A 280
ASP A 326
PHE A 432
 None
 1.30A 5yn6A-5erbA:
undetectable		 5yn6A-5erbA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 270
ILE A  11
ASP A 266
HIS A 267
 None
 0.85A 6ag0A-5erbA:
undetectable		 6ag0A-5erbA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 8 ILE A 330
THR A 331
GLU A 339
SER A 338
 None
 0.96A 6c06C-5erbA:
undetectable		 6c06C-5erbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 190
 None
 0.91A 6dgxA-5erbA:
undetectable		 6dgxA-5erbA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		6 / 12 LEU A 187
GLY A 208
ALA A 207
ILE A  14
ILE A 441
ILE A 190
 None
 1.11A 6dh3A-5erbA:
undetectable		 6dh3A-5erbA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 5 LEU A 527
ARG A 480
PRO A 607
ARG A 473
 None
 1.25A 6ew0B-5erbA:
undetectable		 6ew0B-5erbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 5 LEU A 527
ARG A 480
PRO A 607
ARG A 473
 None
 1.25A 6ew0D-5erbA:
undetectable		 6ew0D-5erbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 5 LEU A 527
ARG A 480
PRO A 607
ARG A 473
 None
 1.25A 6ew0H-5erbA:
undetectable		 6ew0H-5erbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 5 LEU A 527
ARG A 480
PRO A 607
ARG A 473
 None
 1.25A 6ew0I-5erbA:
undetectable		 6ew0I-5erbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5erb POLYKETIDE SYNTHASE
(Bacillus
amyloliquefacien
s) 		4 / 6 LEU A 603
THR A 501
GLY A 110
ARG A 506
 None
 1.30A 6gtqB-5erbA:
undetectable
6gtqD-5erbA:
undetectable		 6gtqB-5erbA:
15.31
6gtqD-5erbA:
6.54