SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5erd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 10 ASP A 215
SER A 123
ALA A 124
THR A 177
ASP A 218
 CA  A 619 (-3.3A)
None
None
None
CA  A 620 ( 2.4A)
 1.45A 1m4dA-5erdA:
undetectable		 1m4dA-5erdA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 9 ASP A 215
SER A 123
ALA A 124
THR A 177
ASP A 218
 CA  A 619 (-3.3A)
None
None
None
CA  A 620 ( 2.4A)
 1.39A 1m4dB-5erdA:
undetectable		 1m4dB-5erdA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 6 THR A 503
ASP A 470
ASN A 446
ASP A 445
 None
CA  A 623 (-2.0A)
CA  A 626 (-4.7A)
CA  A 626 ( 2.4A)
 1.26A 2okcA-5erdA:
undetectable		 2okcA-5erdA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 6 ILE A 485
PRO A 448
LEU A 450
ILE A 523
 None
 0.97A 2q83B-5erdA:
undetectable		 2q83B-5erdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 7 TYR A 319
VAL A 303
VAL A 246
VAL A 223
 None
 0.99A 2qbnA-5erdA:
undetectable		 2qbnA-5erdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 SER A 148
GLN A 112
PHE A 115
ILE A 132
PHE A 110
 None
 1.32A 2vdyA-5erdA:
undetectable		 2vdyA-5erdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 VAL A 343
SER A 345
THR A 435
ILE A 398
ASN A 439
 MAN  A 615 ( 3.6A)
None
MAN  A 615 (-2.2A)
None
None
 1.17A 3ddyA-5erdA:
undetectable		 3ddyA-5erdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 4 GLY A 230
VAL A 241
GLY A 283
THR A 276
 None
 0.92A 3ib2A-5erdA:
undetectable		 3ib2A-5erdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 4 ASP A 250
ASP A 248
GLY A 253
THR A 276
 CA  A 619 ( 3.6A)
CA  A 621 (-2.2A)
None
None
 1.32A 3tl9B-5erdA:
undetectable		 3tl9B-5erdA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 SER A 148
GLN A 112
PHE A 115
ILE A 132
PHE A 110
 None
 1.18A 4c49A-5erdA:
undetectable		 4c49A-5erdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 SER A 148
GLN A 112
PHE A 115
ILE A 132
PHE A 110
 None
 1.32A 4c49C-5erdA:
undetectable		 4c49C-5erdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 6 GLU A 107
ASP A 138
ASP A 102
GLU A  11
 None
CA  A 616 ( 3.3A)
CA  A 616 (-3.4A)
CA  A 617 ( 2.5A)
 1.38A 4ntxA-5erdA:
undetectable
4ntxC-5erdA:
undetectable		 4ntxA-5erdA:
21.22
4ntxC-5erdA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 ALA A  22
ALA A  82
GLY A  80
TYR A  40
TYR A  38
 None
 1.17A 4r29A-5erdA:
undetectable		 4r29A-5erdA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 ALA A  22
ALA A  82
GLY A  80
TYR A  40
TYR A  38
 None
 1.16A 4r29B-5erdA:
undetectable		 4r29B-5erdA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 ALA A  22
ALA A  82
GLY A  80
TYR A  40
TYR A  38
 None
 1.19A 4r29C-5erdA:
undetectable		 4r29C-5erdA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		4 / 5 GLN A 365
HIS A 338
ILE A 432
TYR A 379
 None
 1.19A 5dnuA-5erdA:
undetectable		 5dnuA-5erdA:
19.92