SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ere'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AEG_A_4APA296_1 (CYTOCHROME C PEROXIDASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	GLY A 134 THR A 136 GLY A 333 LEU A 128	None	0.83A	1aegA-5ereA: undetectable	1aegA-5ereA: 19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BDW_A_DVAA6_0 (GRAMICIDIN A)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	3 / 3	ALA A 76 VAL A 78 TRP A 104	None	0.84A	1bdwA-5ereA: undetectable 1bdwB-5ereA: undetectable	1bdwA-5ereA: 2.58 1bdwB-5ereA: 2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_I_BEZI518_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	ILE A 216 GLY A 170 PRO A 242 ASN A 167	None None COI A 601 ( 4.4A) None	0.76A	1oniG-5ereA: undetectable 1oniI-5ereA: undetectable	1oniG-5ereA: 14.47 1oniI-5ereA: 14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q0Y_H_MOIH401_1 (FAB 9B1, HEAVY CHAIN FAB 9B1, LIGHT CHAIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	GLU A 146 ILE A 243 TRP A 173 LEU A 169	None None None COI A 601 (-3.7A)	1.36A	1q0yH-5ereA: undetectable 1q0yL-5ereA: undetectable	1q0yH-5ereA: 18.02 1q0yL-5ereA: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TYR_B_9CRB130_1 (TRANSTHYRETIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	LEU A 511 THR A 591 ALA A 589 SER A 578	None	0.83A	1tyrB-5ereA: undetectable	1tyrB-5ereA: 12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	TYR A 315 PHE A 329 ALA A 122 LEU A 293	None	1.09A	1x8vA-5ereA: undetectable	1x8vA-5ereA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOU_B_CQAB401_0 (HISTAMINE N-METHYLTRANSFERASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	PHE A 285 PRO A 242 TYR A 339 THR A 140	None COI A 601 ( 4.4A) None None	1.13A	2aouB-5ereA: 5.0	2aouB-5ereA: 18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXK_A_IMNA2001_1 (SERUM ALBUMIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	PHE A 509 ALA A 589 ARG A 587 LEU A 574	None	1.07A	2bxkA-5ereA: undetectable	2bxkA-5ereA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C12_C_SPMC1434_1 (NITROALKANE OXIDASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	LEU A 293 GLU A 289 LEU A 128 LEU A 139 ASP A 334	None	1.19A	2c12C-5ereA: undetectable	2c12C-5ereA: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C12_F_SPMF1433_1 (NITROALKANE OXIDASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 11	LEU A 293 GLU A 289 LEU A 128 LEU A 139 ASP A 334	None	1.16A	2c12F-5ereA: undetectable	2c12F-5ereA: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_A_BEZA1003_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	SER A 100 LEU A 112 HIS A 110 THR A 136	None	1.12A	2f78A-5ereA: 4.4	2f78A-5ereA: 18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA501_1 (CYTOCHROME P450 2C8)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 11	GLY A 124 SER A 106 ILE A 38 SER A 100 ALA A 84	COI A 601 (-4.1A) None None None None	0.94A	2nnhA-5ereA: undetectable	2nnhA-5ereA: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q72_A_IXXA802_1 (TRANSPORTER)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 6	ILE A 496 SER A 495 ILE A 467 PHE A 371	None	1.07A	2q72A-5ereA: undetectable	2q72A-5ereA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEI_A_CXXA802_1 (TRANSPORTER)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 6	SER A 495 PHE A 492 ILE A 467 PHE A 371	None	1.29A	2qeiA-5ereA: undetectable	2qeiA-5ereA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQT_A_AINA596_1 (LACTOPEROXIDASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 6	GLU A 462 PHE A 464 GLN A 489 PRO A 490	CYT A 602 (-2.8A) None None None	1.39A	2qqtA-5ereA: 0.1	2qqtA-5ereA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 10	TYR A 191 ILE A 198 LEU A 213 VAL A 214 LEU A 215	None	1.47A	2w98A-5ereA: 5.3	2w98A-5ereA: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WSC_B_PQNB1773_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 10	PHE A 67 SER A 63 ALA A 300 LEU A 301 ALA A 66	None	1.47A	2wscB-5ereA: undetectable	2wscB-5ereA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WSE_B_PQNB1774_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 10	PHE A 67 SER A 63 ALA A 300 LEU A 301 ALA A 66	None	1.46A	2wseB-5ereA: undetectable	2wseB-5ereA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WSF_B_PQNB1773_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 9	PHE A 67 SER A 63 ALA A 300 LEU A 301 ALA A 66	None	1.48A	2wsfB-5ereA: undetectable	2wsfB-5ereA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_B_QPSB1060_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 10	VAL A 98 SER A 106 SER A 125 GLY A 74 ALA A 81	None	1.39A	2x2iB-5ereA: undetectable	2x2iB-5ereA: 19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGN_A_PCFA1179_1 (WNT INHIBITORY FACTOR 1)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 5	PHE A 329 PRO A 338 VAL A 37 PHE A 285	None	1.07A	2ygnA-5ereA: undetectable	2ygnA-5ereA: 15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CL9_A_MTXA602_2 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS))	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 4	VAL A 238 ARG A 180 ILE A 174 THR A 261	None	1.27A	3cl9A-5ereA: undetectable	3cl9A-5ereA: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWV_A_RFXA801_1 (TRANSPORTER)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	LEU A 258 GLY A 257 LEU A 237 ALA A 212 LEU A 150	None	0.93A	3gwvA-5ereA: undetectable	3gwvA-5ereA: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_A_EPAA1_2 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	LEU A 588 ILE A 370 ILE A 496 MET A 374 LEU A 454	None	1.33A	3gwxA-5ereA: undetectable	3gwxA-5ereA: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TF1_A_ACTA191_0 (METHYL-ACCEPTING CHEMOTAXIS PROTEIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 5	THR A 488 ILE A 467 PHE A 371 LEU A 469	None	1.39A	3tf1A-5ereA: undetectable	3tf1A-5ereA: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E3H_A_HQEA303_1 (CARBONIC ANHYDRASE 2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 10	VAL A 121 VAL A 99 LEU A 297 THR A 296 VAL A 35	None	1.06A	4e3hA-5ereA: undetectable	4e3hA-5ereA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KT0_A_PQNA2001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 11	GLY A 392 ARG A 391 LEU A 390 GLY A 389 LEU A 581	None	1.08A	4kt0A-5ereA: undetectable 4kt0J-5ereA: undetectable	4kt0A-5ereA: 22.61 4kt0J-5ereA: 6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWJ_B_30ZB201_1 (TRANSTHYRETIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	LEU A 511 THR A 591 ALA A 589 SER A 578	None	0.64A	4pwjB-5ereA: undetectable	4pwjB-5ereA: 15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZT_C_RTLC201_0 (RETINOL-BINDING PROTEIN 2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	ILE A 205 ALA A 228 GLN A 227 TYR A 191 LEU A 163	None	1.49A	4qztC-5ereA: undetectable	4qztC-5ereA: 11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XDT_A_ACTA407_0 (FAD:PROTEIN FMN TRANSFERASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	3 / 3	ASP A 436 GLY A 419 ASP A 416	None	0.67A	4xdtA-5ereA: undetectable	4xdtA-5ereA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BOJ_B_4TXB201_1 (TRANSTHYRETIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	LEU A 511 THR A 591 ALA A 589 SER A 578	None	0.65A	5bojB-5ereA: undetectable	5bojB-5ereA: 12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FUK_A_SNPA1236_1 (MROUPO)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	ILE A 467 ILE A 579 ILE A 496 LEU A 588	None	0.81A	5fukA-5ereA: undetectable 5fukB-5ereA: undetectable	5fukA-5ereA: 19.00 5fukB-5ereA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J7W_C_MTXC402_1 (THYMIDYLATE SYNTHASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	ILE A 518 GLY A 494 PHE A 493 ILE A 526 ALA A 523	None ACY A 603 (-3.7A) ACY A 603 (-4.6A) None None	1.19A	5j7wC-5ereA: undetectable	5j7wC-5ereA: 18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JQ7_B_T0RB705_1 (ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1 ENVELOPE GLYCOPROTEIN 2)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 7	VAL A 378 LEU A 402 ALA A 379 LEU A 469 LEU A 581	None	1.36A	5jq7A-5ereA: undetectable	5jq7A-5ereA: 22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_B_08JB602_1 (CYTOCHROME P450 3A4)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	SER A 103 THR A 240 ILE A 243 ALA A 218	COI A 601 (-2.4A) None None COI A 601 ( 4.3A)	0.81A	5te8B-5ereA: undetectable	5te8B-5ereA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UXD_B_ZITB501_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E MPHH)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	LEU A 39 VAL A 37 PHE A 271 ALA A 323 GLY A 325	None	1.01A	5uxdB-5ereA: undetectable	5uxdB-5ereA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZVG_A_SAMA401_0 (389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	ALA A 382 GLY A 389 SER A 485 ASP A 375 PRO A 472	None None CYT A 602 (-3.5A) None None	1.13A	5zvgA-5ereA: undetectable	5zvgA-5ereA: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZVG_B_SAMB401_0 (389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	ALA A 382 GLY A 389 SER A 485 ASP A 375 PRO A 472	None None CYT A 602 (-3.5A) None None	1.16A	5zvgB-5ereA: 2.2	5zvgB-5ereA: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BRD_A_RFPA502_1 (RIFAMPIN MONOOXYGENASE)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	5 / 12	HIS A 447 VAL A 453 VAL A 461 THR A 420 GLY A 419	None None CYT A 602 (-3.7A) None None	1.10A	6brdA-5ereA: undetectable	6brdA-5ereA: 9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD6_A_STIA603_1 (TYROSINE-PROTEIN KINASE ABL1)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 5	LEU A 324 TYR A 265 ILE A 216 GLY A 287	None	0.96A	6hd6A-5ereA: 0.7	6hd6A-5ereA: 8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_A_TKTA508_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	ASP A 334 ILE A 137 ARG A 138 ARG A 130	None None EDO A 606 (-2.7A) None	1.21A	6hisA-5ereA: undetectable 6hisB-5ereA: undetectable	6hisA-5ereA: 8.98 6hisB-5ereA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_B_TKTB508_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	ASP A 334 ILE A 137 ARG A 138 ARG A 130	None None EDO A 606 (-2.7A) None	1.21A	6hisB-5ereA: undetectable 6hisC-5ereA: undetectable	6hisB-5ereA: 8.98 6hisC-5ereA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_C_TKTC508_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	ASP A 334 ILE A 137 ARG A 138 ARG A 130	None None EDO A 606 (-2.7A) None	1.21A	6hisC-5ereA: undetectable 6hisD-5ereA: undetectable	6hisC-5ereA: 8.98 6hisD-5ereA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_D_TKTD501_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	ASP A 334 ILE A 137 ARG A 138 ARG A 130	None None EDO A 606 (-2.7A) None	1.21A	6hisD-5ereA: undetectable 6hisE-5ereA: undetectable	6hisD-5ereA: 8.98 6hisE-5ereA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_E_TKTE501_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 8	ASP A 334 ILE A 137 ARG A 138 ARG A 130	None None EDO A 606 (-2.7A) None	1.21A	6hisA-5ereA: undetectable 6hisE-5ereA: undetectable	6hisA-5ereA: 8.98 6hisE-5ereA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6J20_A_GBQA1201_1 (SUBSTANCE-P RECEPTOR,ENDOLYSIN)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	ILE A 443 GLN A 440 GLU A 435 VAL A 415	None CYT A 602 (-2.9A) None None	1.12A	6j20A-5ereA: undetectable	6j20A-5ereA: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MA7_A_TPFA602_0 (CYTOCHROME P450 3A4)	5ere	EXTRACELLULAR LIGAND-BINDING RECEPTOR (Desulfohalobium retbaense)	4 / 7	SER A 103 THR A 240 ILE A 243 ALA A 218	COI A 601 (-2.4A) None None COI A 601 ( 4.3A)	0.81A	6ma7A-5ereA: undetectable	6ma7A-5ereA: 8.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AEG_A_4APA296_1","CYTOCHROME C PEROXIDASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"GLY A 134;THR A 136;GLY A 333;LEU A 128","None","0.83A","1aegA-5ereA:undetectable","1aegA-5ereA:19.26"],["1BDW_A_DVAA6_0","GRAMICIDIN A","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",3,"ALA A  76;VAL A  78;TRP A 104","None","0.84A","1bdwA-5ereA:undetectable;1bdwB-5ereA:undetectable","1bdwA-5ereA:2.58;1bdwB-5ereA:2.58"],["1ONI_I_BEZI518_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ILE A 216;GLY A 170;PRO A 242;ASN A 167","None;None;COI A 601 ( 4.4A);None","0.76A","1oniG-5ereA:undetectable;1oniI-5ereA:undetectable","1oniG-5ereA:14.47;1oniI-5ereA:14.47"],["1Q0Y_H_MOIH401_1","FAB 9B1, HEAVY CHAIN;FAB 9B1, LIGHT CHAIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"GLU A 146;ILE A 243;TRP A 173;LEU A 169","None;None;None;COI A 601 (-3.7A)","1.36A","1q0yH-5ereA:undetectable;1q0yL-5ereA:undetectable","1q0yH-5ereA:18.02;1q0yL-5ereA:18.72"],["1TYR_B_9CRB130_1","TRANSTHYRETIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"LEU A 511;THR A 591;ALA A 589;SER A 578","None","0.83A","1tyrB-5ereA:undetectable","1tyrB-5ereA:12.13"],["1X8V_A_ESLA471_1","CYTOCHROME P450 51","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"TYR A 315;PHE A 329;ALA A 122;LEU A 293","None","1.09A","1x8vA-5ereA:undetectable","1x8vA-5ereA:22.37"],["2AOU_B_CQAB401_0","HISTAMINE N-METHYLTRANSFERASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"PHE A 285;PRO A 242;TYR A 339;THR A 140","None;COI A 601 ( 4.4A);None;None","1.13A","2aouB-5ereA:5.0","2aouB-5ereA:18.95"],["2BXK_A_IMNA2001_1","SERUM ALBUMIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"PHE A 509;ALA A 589;ARG A 587;LEU A 574","None","1.07A","2bxkA-5ereA:undetectable","2bxkA-5ereA:22.37"],["2C12_C_SPMC1434_1","NITROALKANE OXIDASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"LEU A 293;GLU A 289;LEU A 128;LEU A 139;ASP A 334","None","1.19A","2c12C-5ereA:undetectable","2c12C-5ereA:22.93"],["2C12_F_SPMF1433_1","NITROALKANE OXIDASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"LEU A 293;GLU A 289;LEU A 128;LEU A 139;ASP A 334","None","1.16A","2c12F-5ereA:undetectable","2c12F-5ereA:22.93"],["2F78_A_BEZA1003_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"SER A 100;LEU A 112;HIS A 110;THR A 136","None","1.12A","2f78A-5ereA:4.4","2f78A-5ereA:18.63"],["2NNH_A_9CRA501_1","CYTOCHROME P450 2C8","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"GLY A 124;SER A 106;ILE A  38;SER A 100;ALA A  84","COI A 601 (-4.1A);None;None;None;None","0.94A","2nnhA-5ereA:undetectable","2nnhA-5ereA:20.21"],["2Q72_A_IXXA802_1","TRANSPORTER","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ILE A 496;SER A 495;ILE A 467;PHE A 371","None","1.07A","2q72A-5ereA:undetectable","2q72A-5ereA:23.10"],["2QEI_A_CXXA802_1","TRANSPORTER","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"SER A 495;PHE A 492;ILE A 467;PHE A 371","None","1.29A","2qeiA-5ereA:undetectable","2qeiA-5ereA:23.10"],["2QQT_A_AINA596_1","LACTOPEROXIDASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"GLU A 462;PHE A 464;GLN A 489;PRO A 490","CYT A 602 (-2.8A);None;None;None","1.39A","2qqtA-5ereA:0.1","2qqtA-5ereA:22.31"],["2W98_A_P1ZA1351_1","PROSTAGLANDIN REDUCTASE 2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"TYR A 191;ILE A 198;LEU A 213;VAL A 214;LEU A 215","None","1.47A","2w98A-5ereA:5.3","2w98A-5ereA:20.21"],["2WSC_B_PQNB1773_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"PHE A  67;SER A  63;ALA A 300;LEU A 301;ALA A  66","None","1.47A","2wscB-5ereA:undetectable","2wscB-5ereA:19.56"],["2WSE_B_PQNB1774_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"PHE A  67;SER A  63;ALA A 300;LEU A 301;ALA A  66","None","1.46A","2wseB-5ereA:undetectable","2wseB-5ereA:19.56"],["2WSF_B_PQNB1773_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"PHE A  67;SER A  63;ALA A 300;LEU A 301;ALA A  66","None","1.48A","2wsfB-5ereA:undetectable","2wsfB-5ereA:19.56"],["2X2I_B_QPSB1060_1","ALPHA-1,4-GLUCAN LYASE ISOZYME 1","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"VAL A  98;SER A 106;SER A 125;GLY A  74;ALA A  81","None","1.39A","2x2iB-5ereA:undetectable","2x2iB-5ereA:19.26"],["2YGN_A_PCFA1179_1","WNT INHIBITORY FACTOR 1","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"PHE A 329;PRO A 338;VAL A  37;PHE A 285","None","1.07A","2ygnA-5ereA:undetectable","2ygnA-5ereA:15.30"],["3CL9_A_MTXA602_2","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"VAL A 238;ARG A 180;ILE A 174;THR A 261","None","1.27A","3cl9A-5ereA:undetectable","3cl9A-5ereA:21.69"],["3GWV_A_RFXA801_1","TRANSPORTER","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"LEU A 258;GLY A 257;LEU A 237;ALA A 212;LEU A 150","None","0.93A","3gwvA-5ereA:undetectable","3gwvA-5ereA:23.39"],["3GWX_A_EPAA1_2","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"LEU A 588;ILE A 370;ILE A 496;MET A 374;LEU A 454","None","1.33A","3gwxA-5ereA:undetectable","3gwxA-5ereA:20.73"],["3TF1_A_ACTA191_0","METHYL-ACCEPTING CHEMOTAXIS PROTEIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"THR A 488;ILE A 467;PHE A 371;LEU A 469","None","1.39A","3tf1A-5ereA:undetectable","3tf1A-5ereA:16.22"],["4E3H_A_HQEA303_1","CARBONIC ANHYDRASE 2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"VAL A 121;VAL A  99;LEU A 297;THR A 296;VAL A  35","None","1.06A","4e3hA-5ereA:undetectable","4e3hA-5ereA:19.78"],["4KT0_A_PQNA2001_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"GLY A 392;ARG A 391;LEU A 390;GLY A 389;LEU A 581","None","1.08A","4kt0A-5ereA:undetectable;4kt0J-5ereA:undetectable","4kt0A-5ereA:22.61;4kt0J-5ereA:6.35"],["4PWJ_B_30ZB201_1","TRANSTHYRETIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"LEU A 511;THR A 591;ALA A 589;SER A 578","None","0.64A","4pwjB-5ereA:undetectable","4pwjB-5ereA:15.19"],["4QZT_C_RTLC201_0","RETINOL-BINDING PROTEIN 2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"ILE A 205;ALA A 228;GLN A 227;TYR A 191;LEU A 163","None","1.49A","4qztC-5ereA:undetectable","4qztC-5ereA:11.09"],["4XDT_A_ACTA407_0","FAD:PROTEIN FMN TRANSFERASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",3,"ASP A 436;GLY A 419;ASP A 416","None","0.67A","4xdtA-5ereA:undetectable","4xdtA-5ereA:22.51"],["5BOJ_B_4TXB201_1","TRANSTHYRETIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"LEU A 511;THR A 591;ALA A 589;SER A 578","None","0.65A","5bojB-5ereA:undetectable","5bojB-5ereA:12.13"],["5FUK_A_SNPA1236_1","MROUPO;MROUPO","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ILE A 467;ILE A 579;ILE A 496;LEU A 588","None","0.81A","5fukA-5ereA:undetectable;5fukB-5ereA:undetectable","5fukA-5ereA:19.00;5fukB-5ereA:19.00"],["5J7W_C_MTXC402_1","THYMIDYLATE SYNTHASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"ILE A 518;GLY A 494;PHE A 493;ILE A 526;ALA A 523","None;ACY A 603 (-3.7A);ACY A 603 (-4.6A);None;None","1.19A","5j7wC-5ereA:undetectable","5j7wC-5ereA:18.88"],["5JQ7_B_T0RB705_1","ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1,ENVELOPE GLYCOPROTEIN 1;ENVELOPE GLYCOPROTEIN 2","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"VAL A 378;LEU A 402;ALA A 379;LEU A 469;LEU A 581","None","1.36A","5jq7A-5ereA:undetectable","5jq7A-5ereA:22.89"],["5TE8_B_08JB602_1","CYTOCHROME P450 3A4","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"SER A 103;THR A 240;ILE A 243;ALA A 218","COI A 601 (-2.4A);None;None;COI A 601 ( 4.3A)","0.81A","5te8B-5ereA:undetectable","5te8B-5ereA:21.05"],["5UXD_B_ZITB501_1","MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"LEU A  39;VAL A  37;PHE A 271;ALA A 323;GLY A 325","None","1.01A","5uxdB-5ereA:undetectable","5uxdB-5ereA:21.60"],["5ZVG_A_SAMA401_0","389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"ALA A 382;GLY A 389;SER A 485;ASP A 375;PRO A 472","None;None;CYT A 602 (-3.5A);None;None","1.13A","5zvgA-5ereA:undetectable","5zvgA-5ereA:22.45"],["5ZVG_B_SAMB401_0","389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"ALA A 382;GLY A 389;SER A 485;ASP A 375;PRO A 472","None;None;CYT A 602 (-3.5A);None;None","1.16A","5zvgB-5ereA:2.2","5zvgB-5ereA:22.45"],["6BRD_A_RFPA502_1","RIFAMPIN MONOOXYGENASE","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",5,"HIS A 447;VAL A 453;VAL A 461;THR A 420;GLY A 419","None;None;CYT A 602 (-3.7A);None;None","1.10A","6brdA-5ereA:undetectable","6brdA-5ereA:9.82"],["6HD6_A_STIA603_1","TYROSINE-PROTEIN KINASE ABL1","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"LEU A 324;TYR A 265;ILE A 216;GLY A 287","None","0.96A","6hd6A-5ereA:0.7","6hd6A-5ereA:8.70"],["6HIS_A_TKTA508_0","5-HYDROXYTRYPTAMINE RECEPTOR 3A","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ASP A 334;ILE A 137;ARG A 138;ARG A 130","None;None;EDO A 606 (-2.7A);None","1.21A","6hisA-5ereA:undetectable;6hisB-5ereA:undetectable","6hisA-5ereA:8.98;6hisB-5ereA:8.98"],["6HIS_B_TKTB508_0","5-HYDROXYTRYPTAMINE RECEPTOR 3A","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ASP A 334;ILE A 137;ARG A 138;ARG A 130","None;None;EDO A 606 (-2.7A);None","1.21A","6hisB-5ereA:undetectable;6hisC-5ereA:undetectable","6hisB-5ereA:8.98;6hisC-5ereA:8.98"],["6HIS_C_TKTC508_0","5-HYDROXYTRYPTAMINE RECEPTOR 3A","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ASP A 334;ILE A 137;ARG A 138;ARG A 130","None;None;EDO A 606 (-2.7A);None","1.21A","6hisC-5ereA:undetectable;6hisD-5ereA:undetectable","6hisC-5ereA:8.98;6hisD-5ereA:8.98"],["6HIS_D_TKTD501_0","5-HYDROXYTRYPTAMINE RECEPTOR 3A","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ASP A 334;ILE A 137;ARG A 138;ARG A 130","None;None;EDO A 606 (-2.7A);None","1.21A","6hisD-5ereA:undetectable;6hisE-5ereA:undetectable","6hisD-5ereA:8.98;6hisE-5ereA:8.98"],["6HIS_E_TKTE501_0","5-HYDROXYTRYPTAMINE RECEPTOR 3A","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ASP A 334;ILE A 137;ARG A 138;ARG A 130","None;None;EDO A 606 (-2.7A);None","1.21A","6hisA-5ereA:undetectable;6hisE-5ereA:undetectable","6hisA-5ereA:8.98;6hisE-5ereA:8.98"],["6J20_A_GBQA1201_1","SUBSTANCE-P RECEPTOR,ENDOLYSIN","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"ILE A 443;GLN A 440;GLU A 435;VAL A 415","None;CYT A 602 (-2.9A);None;None","1.12A","6j20A-5ereA:undetectable","6j20A-5ereA:22.56"],["6MA7_A_TPFA602_0","CYTOCHROME P450 3A4","5ere","EXTRACELLULAR LIGAND-BINDING RECEPTOR","Desulfohalobium retbaense",4,"SER A 103;THR A 240;ILE A 243;ALA A 218","COI A 601 (-2.4A);None;None;COI A 601 ( 4.3A)","0.81A","6ma7A-5ereA:undetectable","6ma7A-5ereA:8.45"]]