SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5erg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 8 GLU B 116
GLY B 118
SER B 121
GLU B 139
ASP B 168
None
SAM  B 401 (-3.4A)
SAM  B 401 (-3.1A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
1.03A 1jg4A-5ergB:
11.5
1jg4A-5ergB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 120
SER B 121
LEU B  87
HIS B 126
ILE B 164
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
None
1.16A 1kyvA-5ergB:
undetectable
1kyvE-5ergB:
undetectable
1kyvA-5ergB:
18.68
1kyvE-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.14A 1kyvA-5ergB:
undetectable
1kyvB-5ergB:
undetectable
1kyvA-5ergB:
18.68
1kyvB-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.14A 1kyvB-5ergB:
undetectable
1kyvC-5ergB:
undetectable
1kyvB-5ergB:
18.68
1kyvC-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.15A 1kyvC-5ergB:
undetectable
1kyvD-5ergB:
undetectable
1kyvC-5ergB:
18.68
1kyvD-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.14A 1kyvD-5ergB:
undetectable
1kyvE-5ergB:
undetectable
1kyvD-5ergB:
18.68
1kyvE-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
PHE B 138
PHE B 152
LEU B 135
LEU B 195
None
1.07A 1og5B-5ergB:
undetectable
1og5B-5ergB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 172
GLY B 173
VAL B 217
SER B 137
LEU B 195
None
0.92A 1ya4C-5ergB:
undetectable
1ya4C-5ergB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 120
ASP B 168
VAL B 169
PRO B 205
SER B 356
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 ( 4.9A)
None
1.07A 1zq9A-5ergB:
13.7
1zq9A-5ergB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
6 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
LEU B 204
PRO B 205
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-4.5A)
SAM  B 401 ( 4.9A)
0.64A 1zq9B-5ergB:
13.6
1zq9B-5ergB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 GLY B 120
SER B 121
LEU B  87
HIS B 126
ILE B 164
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
None
1.12A 2a58A-5ergB:
undetectable
2a58E-5ergB:
undetectable
2a58A-5ergB:
18.68
2a58E-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.13A 2a58A-5ergB:
undetectable
2a58B-5ergB:
undetectable
2a58A-5ergB:
18.68
2a58B-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.13A 2a58B-5ergB:
undetectable
2a58C-5ergB:
undetectable
2a58B-5ergB:
18.68
2a58C-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.13A 2a58C-5ergB:
undetectable
2a58D-5ergB:
undetectable
2a58C-5ergB:
18.68
2a58D-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
1.13A 2a58D-5ergB:
undetectable
2a58E-5ergB:
undetectable
2a58D-5ergB:
18.68
2a58E-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 8 ASP B 241
LYS B 245
GLY B 247
ASP B 250
None
1.05A 2aouA-5ergB:
12.1
2aouA-5ergB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
3 / 3 GLY B 118
GLU B 139
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.3A)
0.35A 2b25B-5ergB:
20.6
2b25B-5ergB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 PHE B  39
ILE B  51
SER B  58
ILE B  13
VAL B  31
None
1.17A 2ft9A-5ergB:
undetectable
2ft9A-5ergB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.87A 2pxcA-5ergB:
8.8
2pxcA-5ergB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 GLU B 116
GLY B 118
GLY B 120
GLU B 139
ASP B 168
None
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
0.84A 3dxyA-5ergB:
11.1
3dxyA-5ergB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLU B 116
GLY B 118
GLY B 120
GLU B 139
ASP B 168
None
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
0.65A 3gryA-5ergB:
14.6
3gryA-5ergB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 GLY B 118
GLU B 139
PHE B 140
ASP B 168
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-4.8A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.75A 3id5B-5ergB:
14.0
3id5B-5ergB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 GLY B 118
GLU B 139
PHE B 140
ASP B 168
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-4.8A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.76A 3id5F-5ergB:
13.9
3id5F-5ergB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLU B 139
PHE B 140
ASP B 168
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-4.8A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.72A 3id6C-5ergB:
13.8
3id6C-5ergB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
GLY B 122
ASP B 168
LEU B 204
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-4.5A)
0.58A 3ihtA-5ergB:
10.0
3ihtA-5ergB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 5 SER B 356
ARG B 144
GLY B 118
GLU B 139
None
SAM  B 401 (-4.7A)
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
1.32A 3k9fA-5ergB:
undetectable
3k9fB-5ergB:
undetectable
3k9fC-5ergB:
undetectable
3k9fA-5ergB:
22.75
3k9fB-5ergB:
22.75
3k9fC-5ergB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 4 GLY B 118
GLU B 139
ASP B 168
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.30A 3mb5A-5ergB:
22.2
3mb5A-5ergB:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLU B 139
PHE B 140
ASP B 168
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-4.8A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.75A 3nvkF-5ergB:
undetectable
3nvkJ-5ergB:
14.7
3nvkF-5ergB:
22.63
3nvkJ-5ergB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.84A 3p97A-5ergB:
8.7
3p97A-5ergB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLU B 116
GLY B 118
GLY B 120
ASP B 168
VAL B 169
None
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
0.63A 3sglA-5ergB:
undetectable
3sglA-5ergB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 6 GLY B 120
GLU B 139
ASP B 168
ASP B 203
SAM  B 401 (-3.3A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.72A 3vywC-5ergB:
10.6
3vywC-5ergB:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.87A 4ctkA-5ergB:
8.7
4ctkA-5ergB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 4 LEU B 226
ILE B 102
GLY B 225
PHE B 360
None
1.04A 4dc3A-5ergB:
3.9
4dc3A-5ergB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
VAL B 169
LEU B 204
PRO B 205
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.7A)
SAM  B 401 (-4.5A)
SAM  B 401 ( 4.9A)
0.80A 4gc9A-5ergB:
10.5
4gc9A-5ergB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 5 HIS B  48
VAL B  38
GLU B  37
VAL B  31
None
1.09A 4p6vB-5ergB:
undetectable
4p6vE-5ergB:
undetectable
4p6vB-5ergB:
21.18
4p6vE-5ergB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
3 / 3 PRO B 205
LEU B 204
HIS B 213
SAM  B 401 ( 4.9A)
SAM  B 401 (-4.5A)
None
0.70A 4pevA-5ergB:
2.6
4pevA-5ergB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 SER B 137
LEU B 135
VAL B  94
ILE B 102
GLY B 120
None
None
SAM  B 401 (-3.8A)
None
SAM  B 401 (-3.3A)
1.03A 4y8wC-5ergB:
undetectable
4y8wC-5ergB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 120
GLY B 122
GLU B 139
ASP B 203
LEU B 204
SAM  B 401 (-3.3A)
SAM  B 401 (-3.9A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.3A)
SAM  B 401 (-4.5A)
0.97A 5c0oF-5ergB:
20.4
5c0oF-5ergB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
SER B 121
GLY B 122
LEU B 204
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
SAM  B 401 (-3.9A)
SAM  B 401 (-4.5A)
0.70A 5c0oH-5ergB:
19.6
5c0oH-5ergB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.87A 5ehgA-5ergB:
8.6
5ehgA-5ergB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.89A 5eifA-5ergB:
8.6
5eifA-5ergB:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
12 / 12 GLN B  92
ILE B  93
VAL B  94
GLY B 122
SER B 123
PHE B 124
HIS B 141
ARG B 144
VAL B 169
CYH B 170
LEU B 204
PRO B 205
None
SAM  B 401 ( 4.3A)
SAM  B 401 (-3.8A)
SAM  B 401 (-3.9A)
SAM  B 401 (-4.2A)
None
None
SAM  B 401 (-4.7A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.6A)
SAM  B 401 (-4.5A)
SAM  B 401 ( 4.9A)
0.05A 5ergB-5ergB:
45.3
5ergB-5ergB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
7 / 7 GLY B 118
GLY B 120
SER B 121
GLU B 139
PHE B 140
ASP B 168
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
SAM  B 401 (-2.9A)
SAM  B 401 (-4.8A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.00A 5ergB-5ergB:
45.3
5ergB-5ergB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 11 GLY B 120
GLU B 139
ASP B 168
VAL B 169
PRO B 205
SAM  B 401 (-3.3A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 ( 4.9A)
1.19A 5hjiA-5ergB:
12.7
5hjiA-5ergB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.85A 5ikmA-5ergB:
8.7
5ikmA-5ergB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.93A 5ikmA-5ergB:
8.7
5ikmA-5ergB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 8 THR B  84
SER B 123
THR B  96
SER B  99
None
SAM  B 401 (-4.2A)
None
None
1.03A 5l4eA-5ergB:
undetectable
5l4eB-5ergB:
undetectable
5l4eC-5ergB:
undetectable
5l4eD-5ergB:
undetectable
5l4eE-5ergB:
undetectable
5l4eA-5ergB:
22.65
5l4eB-5ergB:
22.65
5l4eC-5ergB:
22.65
5l4eD-5ergB:
22.65
5l4eE-5ergB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.90A 5njvA-5ergB:
8.6
5njvA-5ergB:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
1.02A 5wz1A-5ergB:
8.6
5wz1A-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
1.01A 5wz1C-5ergB:
8.6
5wz1C-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
1.02A 5wz1D-5ergB:
8.6
5wz1D-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
1.04A 5wz1F-5ergB:
8.5
5wz1F-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
1.01A 5wz1G-5ergB:
8.6
5wz1G-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 122
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
1.00A 5wz1H-5ergB:
8.5
5wz1H-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.89A 5wz2A-5ergB:
8.7
5wz2A-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
5 / 12 GLY B 118
GLY B 120
ASP B 168
VAL B 169
ASP B 203
SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.7A)
SAM  B 401 (-3.3A)
0.85A 5wz2B-5ergB:
8.7
5wz2B-5ergB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 6 GLU B 139
ARG B 144
ASP B 168
ASP B 203
SAM  B 401 (-2.9A)
SAM  B 401 (-4.7A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
0.53A 5zw4A-5ergB:
17.0
5zw4A-5ergB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
4 / 6 SER B 125
GLU B 139
ARG B 144
ASP B 168
None
SAM  B 401 (-2.9A)
SAM  B 401 (-4.7A)
SAM  B 401 (-3.5A)
1.09A 5zw4A-5ergB:
17.0
5zw4A-5ergB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae)
3 / 3 GLY B 122
THR B 119
GLU B 116
SAM  B 401 (-3.9A)
None
None
0.65A 6b58A-5ergB:
2.9
6b58A-5ergB:
20.45