SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5erm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		3 / 3 GLU A 290
ASP A 307
TYR A 311
 None
 0.79A 2yvlB-5ermA:
undetectable		 2yvlB-5ermA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		3 / 3 LEU A 214
TRP A 162
TYR A 305
 None
 0.99A 3aicB-5ermA:
undetectable		 3aicB-5ermA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		3 / 3 LEU A 214
TRP A 162
TYR A 305
 None
 1.01A 3aicE-5ermA:
undetectable		 3aicE-5ermA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 7 SER A 320
SER A 236
GLU A 240
ASP A  96
 None
MG  A 405 ( 2.3A)
MG  A 405 (-2.5A)
MG  A 403 (-2.4A)
 1.09A 3bc9A-5ermA:
undetectable		 3bc9A-5ermA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 5 TYR A 311
VAL A  25
SER A 314
GLY A  22
 None
 1.17A 3v4tA-5ermA:
undetectable
3v4tD-5ermA:
undetectable		 3v4tA-5ermA:
23.11
3v4tD-5ermA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 12 VAL A  70
TYR A 305
ILE A 209
GLY A 206
ILE A  74
 None
 0.99A 4iv0A-5ermA:
undetectable		 4iv0A-5ermA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 12 VAL A  70
TYR A 305
ILE A 209
GLY A 206
ILE A  74
 None
 0.97A 4mwzB-5ermA:
undetectable		 4mwzB-5ermA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 6 ASP A  96
ASP A  92
ASN A 232
ARG A 188
 MG  A 403 (-2.4A)
MG  A 404 (-2.3A)
210  A 401 ( 2.5A)
210  A 401 ( 2.3A)
 1.29A 4ntxA-5ermA:
undetectable
4ntxC-5ermA:
undetectable		 4ntxA-5ermA:
21.71
4ntxC-5ermA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		6 / 9 ASP A  92
ARG A 188
ASN A 232
SER A 236
GLU A 240
ARG A 325
 MG  A 404 (-2.3A)
210  A 401 ( 2.3A)
210  A 401 ( 2.5A)
MG  A 405 ( 2.3A)
MG  A 405 (-2.5A)
210  A 401 (-3.1A)
 0.71A 5dz2A-5ermA:
23.1		 5dz2A-5ermA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		6 / 9 ASP A  92
ASN A 232
SER A 236
GLU A 240
ARG A 325
TYR A 326
 MG  A 404 (-2.3A)
210  A 401 ( 2.5A)
MG  A 405 ( 2.3A)
MG  A 405 (-2.5A)
210  A 401 (-3.1A)
210  A 401 (-4.5A)
 0.52A 5dz2A-5ermA:
23.1		 5dz2A-5ermA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		7 / 9 ASP A  92
ARG A 188
ASN A 232
SER A 236
GLU A 240
ARG A 325
TYR A 326
 MG  A 404 (-2.3A)
210  A 401 ( 2.3A)
210  A 401 ( 2.5A)
MG  A 405 ( 2.3A)
MG  A 405 (-2.5A)
210  A 401 (-3.1A)
210  A 401 (-4.5A)
 0.71A 5dz2B-5ermA:
23.0		 5dz2B-5ermA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 9 ASP A  96
ARG A 188
ASN A 232
SER A 236
TYR A 326
 MG  A 403 (-2.4A)
210  A 401 ( 2.3A)
210  A 401 ( 2.5A)
MG  A 405 ( 2.3A)
210  A 401 (-4.5A)
 1.34A 5dz2B-5ermA:
23.0		 5dz2B-5ermA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5erm FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 5 LEU A 205
VAL A 201
MET A 309
CYH A 217
 None
 1.42A 5te0A-5ermA:
undetectable		 5te0A-5ermA:
20.70