SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ern'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 10 ASP A 173
GLY A 177
ILE A 172
ARG A 213
GLY A 212
 None
 1.49A 1fohA-5ernA:
undetectable		 1fohA-5ernA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 10 ASP A 173
GLY A 177
ILE A 172
ARG A 213
GLY A 212
 None
 1.46A 1fohB-5ernA:
undetectable		 1fohB-5ernA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 10 ASP A 173
GLY A 177
ILE A 172
ARG A 213
GLY A 212
 None
 1.49A 1fohC-5ernA:
undetectable		 1fohC-5ernA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 5 LEU A 210
TRP A  62
MET A 324
LEU A 328
 None
 1.04A 1p93D-5ernA:
3.2		 1p93D-5ernA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 11 SER A  84
LEU A  85
THR A 176
GLN A 216
ASP A 219
 None
 0.96A 1rqjA-5ernA:
20.2		 1rqjA-5ernA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 11 SER A  84
LEU A  85
THR A 176
GLN A 216
ASP A 219
 None
 0.94A 1rqjB-5ernA:
20.2		 1rqjB-5ernA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 12 LEU A  85
ASP A  88
GLN A 150
THR A 176
GLN A 216
 None
 0.91A 2f94F-5ernA:
8.0		 2f94F-5ernA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 6 ILE A 286
SER A 291
LEU A 292
THR A 295
 None
 0.63A 3deuB-5ernA:
undetectable		 3deuB-5ernA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		3 / 3 LEU A 302
HIS A 303
MET A 299
 None
 0.87A 3thrD-5ernA:
undetectable		 3thrD-5ernA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 12 VAL A  77
THR A 208
PHE A  55
ILE A  56
HIS A 205
 None
 1.23A 4c49C-5ernA:
undetectable		 4c49C-5ernA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 6 LEU A 211
LEU A 207
ILE A 313
THR A 184
 None
 0.95A 4do3B-5ernA:
undetectable		 4do3B-5ernA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 5 ALA A  58
ILE A 313
LEU A 207
ASN A 321
 None
 1.13A 4g19A-5ernA:
undetectable		 4g19A-5ernA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 12 LEU A  85
ASP A  88
GLN A 150
THR A 176
GLN A 216
 None
 0.97A 4ng6A-5ernA:
13.4		 4ng6A-5ernA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 9 LEU A  85
ASP A  88
GLN A 150
LYS A 175
THR A 176
 None
 1.11A 4umjB-5ernA:
12.9		 4umjB-5ernA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		5 / 12 LEU A  87
THR A 117
ILE A 120
ILE A 143
MET A 140
 None
 1.28A 5ifuA-5ernA:
undetectable		 5ifuA-5ernA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5ern FUSICOCCADIENE
SYNTHASE
(Diaporthe
amygdali) 		4 / 8 ILE A 182
ILE A 120
ALA A 123
ILE A 124
 None
 0.60A 5mvmA-5ernA:
4.1
5mvmB-5ernA:
4.2		 5mvmA-5ernA:
13.50
5mvmB-5ernA:
13.50