SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5erp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		5 / 11 VAL A 383
GLY A 429
ILE A 409
PRO A 379
THR A 380
 None
NAG  A 806 ( 4.5A)
NAG  A 806 (-3.5A)
None
None
 0.90A 1c6yA-5erpA:
undetectable		 1c6yA-5erpA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		5 / 11 GLY A 167
THR A 166
HIS A 163
THR A 170
GLY A 128
 None
 1.33A 2fn1B-5erpA:
undetectable		 2fn1B-5erpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		4 / 5 ASN A 304
LEU A 261
GLY A 301
THR A 221
 CA  A 816 (-2.8A)
None
None
None
 0.92A 3dl9A-5erpA:
undetectable		 3dl9A-5erpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		5 / 9 VAL A 383
GLY A 429
ILE A 409
PRO A 379
THR A 380
 None
NAG  A 806 ( 4.5A)
NAG  A 806 (-3.5A)
None
None
 1.13A 3el4B-5erpA:
undetectable		 3el4B-5erpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		4 / 8 GLY A 429
ILE A 409
PRO A 379
THR A 380
 NAG  A 806 ( 4.5A)
NAG  A 806 (-3.5A)
None
None
 0.82A 3el9A-5erpA:
undetectable		 3el9A-5erpA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		4 / 7 ASP A 465
ASP A 434
GLN A 433
GLU A 401
 CA  A 817 ( 3.2A)
CA  A 817 (-3.0A)
None
CA  A 817 ( 2.5A)
 1.10A 3l2vA-5erpA:
undetectable		 3l2vA-5erpA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		4 / 8 ASP A 465
ASP A 434
GLN A 433
GLU A 401
 CA  A 817 ( 3.2A)
CA  A 817 (-3.0A)
None
CA  A 817 ( 2.5A)
 1.12A 3oyaA-5erpA:
undetectable		 3oyaA-5erpA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		3 / 3 GLN A 201
THR A 202
THR A 203
 None
None
MAN  A 801 (-2.1A)
 0.56A 4fu9A-5erpA:
undetectable		 4fu9A-5erpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		3 / 3 GLN A 201
THR A 202
THR A 203
 None
None
MAN  A 801 (-2.1A)
 0.56A 4fufA-5erpA:
undetectable		 4fufA-5erpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		5 / 12 VAL A 383
GLY A 429
ILE A 409
PRO A 379
THR A 380
 None
NAG  A 806 ( 4.5A)
NAG  A 806 (-3.5A)
None
None
 1.05A 4njvA-5erpA:
undetectable		 4njvA-5erpA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		5 / 11 VAL A 383
GLY A 429
ILE A 409
PRO A 379
THR A 380
 None
NAG  A 806 ( 4.5A)
NAG  A 806 (-3.5A)
None
None
 1.03A 4njvB-5erpA:
undetectable		 4njvB-5erpA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		5 / 12 VAL A 383
GLY A 429
ILE A 409
PRO A 379
THR A 380
 None
NAG  A 806 ( 4.5A)
NAG  A 806 (-3.5A)
None
None
 1.13A 4njvD-5erpA:
undetectable		 4njvD-5erpA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		4 / 8 ILE A 448
VAL A 513
LEU A 529
ILE A 515
 None
 0.74A 4r38A-5erpA:
undetectable		 4r38A-5erpA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		4 / 7 GLY A 301
GLN A 299
TYR A 225
PHE A 220
 None
 1.18A 4ws0A-5erpA:
undetectable		 4ws0A-5erpA:
21.47