SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5es2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 ALA A 190
LEU A 366
VAL A 369
LEU A 370
ILE A 337
 None
EDO  A 506 (-4.1A)
None
None
ACT  A 505 ( 4.3A)
 0.99A 1df7A-5es2A:
undetectable		 1df7A-5es2A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 PHE A  75
LEU A 129
GLY A 128
TYR A 168
ALA A 164
 None
 1.23A 1hvyA-5es2A:
undetectable		 1hvyA-5es2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 11 PHE A  75
LEU A 129
GLY A 128
TYR A 168
ALA A 164
 None
 1.27A 1ju6A-5es2A:
undetectable		 1ju6A-5es2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 11 PHE A  75
LEU A 129
GLY A 128
TYR A 168
ALA A 164
 None
 1.27A 1ju6D-5es2A:
undetectable		 1ju6D-5es2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 ILE A 298
THR A 301
GLY A 282
SER A 308
TYR A 288
 None
SO4  A 507 (-3.3A)
None
None
None
 1.04A 1rjdA-5es2A:
undetectable		 1rjdA-5es2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 ILE A 298
THR A 301
GLY A 282
SER A 308
TYR A 288
 None
SO4  A 507 (-3.3A)
None
None
None
 1.07A 1rjdB-5es2A:
undetectable		 1rjdB-5es2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 ILE A 298
THR A 301
GLY A 282
SER A 308
TYR A 288
 None
SO4  A 507 (-3.3A)
None
None
None
 1.04A 1rjdC-5es2A:
undetectable		 1rjdC-5es2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 LEU A 133
LEU A 129
ALA A  78
VAL A  82
LEU A  38
 None
 1.27A 3b0wA-5es2A:
undetectable		 3b0wA-5es2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		4 / 7 GLU A  62
LEU A  53
LYS A  16
ASN A  54
 None
 1.40A 3k8mB-5es2A:
undetectable		 3k8mB-5es2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		4 / 6 ARG A 127
GLY A 128
GLU A 175
GLU A 171
 ACT  A 505 ( 4.9A)
None
None
None
 0.81A 3k9fA-5es2A:
undetectable
3k9fB-5es2A:
undetectable
3k9fD-5es2A:
undetectable		 3k9fA-5es2A:
20.65
3k9fB-5es2A:
20.65
3k9fD-5es2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 PHE A  75
LEU A 129
GLY A 128
TYR A 168
ALA A 164
 None
 1.13A 4eb4A-5es2A:
undetectable		 4eb4A-5es2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 PHE A  75
LEU A 129
GLY A 128
TYR A 168
ALA A 164
 None
 1.15A 4eb4B-5es2A:
undetectable		 4eb4B-5es2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		4 / 6 GLY A 275
PHE A 248
ILE A 332
PHE A 364
 None
 0.99A 4qogA-5es2A:
undetectable
4qogB-5es2A:
undetectable		 4qogA-5es2A:
21.04
4qogB-5es2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		4 / 4 LEU A 307
ILE A 284
HIS A 304
VAL A 280
 None
 1.18A 4xyzA-5es2A:
undetectable		 4xyzA-5es2A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		4 / 8 ILE A  35
ASN A  54
THR A  22
PHE A  19
 None
 1.04A 5x23A-5es2A:
undetectable		 5x23A-5es2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		5 / 12 LEU A 307
GLY A 306
TYR A 278
MET A 277
ALA A 274
 None
 1.02A 5x5qB-5es2A:
undetectable		 5x5qB-5es2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5es2 UNCHARACTERIZED
PROTEIN LPG0634
(Legionella
pneumophila) 		4 / 6 ILE A 136
LEU A 146
ARG A 381
THR A 382
 None
 1.03A 6nmfN-5es2A:
2.0
6nmfW-5es2A:
undetectable		 6nmfN-5es2A:
20.68
6nmfW-5es2A:
8.65