SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5es9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.45A 1kiaA-5es9A:
2.2		 1kiaA-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.45A 1kiaB-5es9A:
2.2		 1kiaB-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 7 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.45A 1kiaC-5es9A:
2.2		 1kiaC-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 7 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.45A 1kiaD-5es9A:
2.1		 1kiaD-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 ASP A  58
ARG A  64
ILE A  48
ASP A  46
ARG A  68
 None
 1.44A 1kijA-5es9A:
undetectable		 1kijA-5es9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.43A 1nbhA-5es9A:
1.9		 1nbhA-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 7 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.43A 1nbhB-5es9A:
undetectable		 1nbhB-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.43A 1nbhC-5es9A:
undetectable		 1nbhC-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 7 TYR A 294
ASN A 544
ARG A 545
TYR A 350
 None
 1.44A 1nbhD-5es9A:
undetectable		 1nbhD-5es9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 10 ASP A 265
LEU A 260
HIS A 324
LEU A 241
ILE A 320
 None
 1.41A 1sq5B-5es9A:
2.6		 1sq5B-5es9A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		6 / 10 GLY A 409
ALA A 410
ASP A 385
ILE A 437
ILE A 402
VAL A 223
 None
 1.47A 1t3rA-5es9A:
undetectable		 1t3rA-5es9A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		3 / 3 LEU A 406
LEU A 208
MET A 274
 None
 0.77A 1ya3B-5es9A:
undetectable		 1ya3B-5es9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 LEU A 400
TYR A 439
ILE A 460
GLY A 482
 None
 0.91A 2du8A-5es9A:
undetectable		 2du8A-5es9A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 LEU A 400
TYR A 439
ILE A 460
GLY A 482
 None
 0.87A 2du8B-5es9A:
2.9		 2du8B-5es9A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 9 TYR A 378
TYR A 478
GLY A 380
TYR A 375
HIS A 405
 None
 1.45A 2zm9A-5es9A:
undetectable		 2zm9A-5es9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 MET A 654
ILE A 600
LEU A 650
PRO A 602
LEU A 581
 None
 1.19A 3a51C-5es9A:
undetectable		 3a51C-5es9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		3 / 3 ARG A 512
GLU A 536
ASP A 343
 None
 0.88A 3g2oA-5es9A:
undetectable		 3g2oA-5es9A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 LEU A 264
HIS A 413
SER A 438
GLY A 409
LEU A 406
 None
 1.32A 3j6pB-5es9A:
undetectable		 3j6pB-5es9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 4 PHE A 205
TYR A 375
VAL A 348
LEU A 345
 None
 1.40A 3keeD-5es9A:
undetectable		 3keeD-5es9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 11 ILE A 504
ILE A 515
GLU A 530
THR A 566
ILE A 533
 None
 0.85A 3kw4A-5es9A:
undetectable		 3kw4A-5es9A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 5 THR A 487
GLY A 539
ASN A 367
TYR A 347
 None
 1.27A 3u8qA-5es9A:
undetectable		 3u8qA-5es9A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 THR A 484
GLY A 482
ARG A 562
ILE A 533
 None
 1.23A 4ac9C-5es9A:
3.4		 4ac9C-5es9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 CYH A 486
ARG A 562
GLY A 539
TYR A 347
ARG A 510
 None
 1.47A 4kosA-5es9A:
undetectable		 4kosA-5es9A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 LEU A 368
GLU A 373
LEU A 208
ARG A 376
 None
 1.15A 5dxeA-5es9A:
undetectable		 5dxeA-5es9A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 GLY A 582
ARG A 569
ASN A 479
THR A 491
LEU A 531
 None
 1.42A 5fhzD-5es9A:
3.9		 5fhzD-5es9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 MET A 492
TYR A 478
LEU A 400
TYR A 375
PHE A 379
 None
 1.38A 5g6sB-5es9A:
undetectable
5g6sC-5es9A:
2.6		 5g6sB-5es9A:
18.29
5g6sC-5es9A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 LEU A 407
LEU A 412
PHE A 205
LEU A 271
 None
 1.02A 5gs4A-5es9A:
undetectable		 5gs4A-5es9A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 ILE A 713
GLY A 727
LEU A 751
LEU A 760
 None
 0.82A 5hs1A-5es9A:
undetectable		 5hs1A-5es9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 ILE A 100
LEU A  21
ILE A   4
TYR A  51
 None
 0.87A 5ieoA-5es9A:
undetectable		 5ieoA-5es9A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 LEU A 264
HIS A 413
SER A 438
GLY A 409
LEU A 406
 None
 1.23A 5m50E-5es9A:
undetectable		 5m50E-5es9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 THR A 404
LEU A 407
VAL A 213
TYR A 231
 None
 1.19A 5ov9B-5es9A:
undetectable		 5ov9B-5es9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 5 GLU A 601
THR A 613
HIS A 607
LEU A 646
 None
 1.09A 5utuH-5es9A:
3.5		 5utuH-5es9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 LEU A 368
GLU A 373
LEU A 208
ARG A 376
 None
 1.19A 6cbzA-5es9A:
undetectable		 6cbzA-5es9A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 7 VAL A 673
LEU A 678
LEU A 616
LEU A 612
 None
 0.63A 6g9bA-5es9A:
undetectable
6g9bB-5es9A:
undetectable		 6g9bA-5es9A:
7.51
6g9bB-5es9A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 ASN A 175
GLU A 518
GLN A 523
PRO A 524
GLY A 526
 None
 1.31A 6gnfC-5es9A:
undetectable		 6gnfC-5es9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 ASP A 265
TYR A 329
ASP A 322
GLU A 311
 None
 1.35A 6mn5A-5es9A:
undetectable		 6mn5A-5es9A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 ASP A 265
TYR A 329
ASP A 322
GLU A 311
 None
 1.29A 6mn5C-5es9A:
undetectable		 6mn5C-5es9A:
8.64