SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5esa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 4 VAL B  47
TRP A 109
TRP B  34
 None
 1.45A 1gmkC-5esaB:
undetectable
1gmkD-5esaB:
undetectable		 1gmkC-5esaB:
6.83
1gmkD-5esaB:
6.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		6 / 12 TYR B  35
GLN B  88
PHE B  97
VAL A  37
ALA A  97
TRP A 109
 None
 0.66A 1h8sA-5esaB:
17.8		 1h8sA-5esaB:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 GLY B  23
GLN B   6
VAL B  32
ALA B  70
 None
 0.78A 1p6kA-5esaB:
undetectable		 1p6kA-5esaB:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  35
PRO B  43
TYR B  86
TYR A  95
 None
 0.74A 2oldA-5esaB:
16.4
2oldB-5esaB:
21.4		 2oldA-5esaB:
46.85
2oldB-5esaB:
46.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 MET B 174
LEU B 135
SER A 184
VAL B 158
 None
 0.81A 2qd2A-5esaB:
undetectable		 2qd2A-5esaB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 9 ALA A  61
TYR A  60
ALA A  58
GLY A  50
ILE A  70
 None
 1.15A 2v7bA-5esaA:
undetectable		 2v7bA-5esaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 9 ALA A  61
TYR A  60
ALA A  58
GLY A  50
ILE A  70
 None
 1.14A 2v7bB-5esaA:
undetectable		 2v7bB-5esaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR B  73
TYR B  85
TRP B  34
ARG B  19
 None
 1.19A 3wipB-5esaB:
2.9
3wipC-5esaB:
undetectable		 3wipB-5esaB:
23.95
3wipC-5esaB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR B  73
TYR B  85
TRP B  34
ARG B  19
 None
 1.26A 3wipC-5esaB:
undetectable
3wipD-5esaB:
2.6		 3wipC-5esaB:
23.95
3wipD-5esaB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 TRP B  34
ARG B  19
THR B  73
TYR B  85
 None
 1.30A 3wipA-5esaB:
2.6
3wipE-5esaB:
2.5		 3wipA-5esaB:
23.95
3wipE-5esaB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 TYR A  95
TRP A 109
VAL B  44
VAL B  46
 None
 1.14A 4aftD-5esaA:
undetectable
4aftE-5esaA:
undetectable		 4aftD-5esaA:
24.90
4aftE-5esaA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TRP B  90
TRP A  47
THR A  35
 None
 1.46A 4bboB-5esaB:
undetectable		 4bboB-5esaB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR B  71
SER B  64
THR B  69
SER B  66
 None
 0.94A 5l4eA-5esaB:
2.5
5l4eB-5esaB:
2.5
5l4eC-5esaB:
2.5
5l4eD-5esaB:
undetectable
5l4eE-5esaB:
2.5		 5l4eA-5esaB:
21.58
5l4eB-5esaB:
21.58
5l4eC-5esaB:
21.58
5l4eD-5esaB:
21.58
5l4eE-5esaB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ASP B  52
TRP B  34
HIS B  33
TYR B  85
 None
 1.42A 5ov9B-5esaB:
undetectable		 5ov9B-5esaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 159
THR B 177
VAL B 132
SER B 130
THR A 123
 None
 1.37A 5v1tA-5esaB:
undetectable		 5v1tA-5esaB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 LEU A 130
PRO A 129
PHE B 134
THR A 171
VAL A 169
 None
 1.16A 6debB-5esaA:
undetectable		 6debB-5esaA:
18.59