SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5esp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5esp I-PANMI
(Podospora
anserina) 		4 / 7 LEU A 114
ARG A  38
THR A  26
LEU A  25
 None
 1.07A 2eikA-5espA:
undetectable
2eikJ-5espA:
undetectable		 2eikA-5espA:
19.96
2eikJ-5espA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5esp I-PANMI
(Podospora
anserina) 		5 / 9 LEU A 126
LEU A 127
ILE A 151
LEU A 144
ILE A  27
 None
 1.20A 2f78A-5espA:
undetectable		 2f78A-5espA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5esp I-PANMI
(Podospora
anserina) 		5 / 9 LEU A 126
LEU A 127
ILE A 151
LEU A 144
ILE A  27
 None
 1.17A 2f7aB-5espA:
undetectable		 2f7aB-5espA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 5esp I-PANMI
(Podospora
anserina) 		4 / 6 THR A 237
VAL A 236
CYH A 221
SER A 241
 None
 1.25A 3b6rB-5espA:
undetectable		 3b6rB-5espA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5esp I-PANMI
(Podospora
anserina) 		4 / 8 ASN A 138
SER A 205
GLU A 177
GLU A  20
 None
None
CA  A 302 (-3.1A)
CA  A 301 (-3.0A)
 1.15A 3sg9B-5espA:
undetectable		 3sg9B-5espA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5esp I-PANMI
(Podospora
anserina) 		5 / 10 VAL A 270
PHE A 180
SER A 199
MET A 294
VAL A 269
 None
 1.45A 4eilD-5espA:
undetectable		 4eilD-5espA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5esp I-PANMI
(Podospora
anserina) 		5 / 12 LEU A 211
VAL A 174
GLY A 178
LEU A 170
SER A 214
 None
 1.36A 4ot2A-5espA:
undetectable		 4ot2A-5espA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5esp I-PANMI
(Podospora
anserina) 		5 / 12 GLY A  15
ASN A   9
ILE A  98
PHE A  62
PHE A  61
 None
 1.14A 4zvmA-5espA:
undetectable
4zvmB-5espA:
undetectable		 4zvmA-5espA:
21.94
4zvmB-5espA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5esp I-PANMI
(Podospora
anserina) 		5 / 11 PHE A  62
PHE A  61
GLY A  15
ASN A   9
ILE A  98
 None
 1.24A 4zvmA-5espA:
undetectable
4zvmB-5espA:
undetectable		 4zvmA-5espA:
21.94
4zvmB-5espA:
21.94