SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5esv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5esv CH03 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 GLY A  33
ARG A  71
PHE A  29
GLY A  95
PHE A  27
 None
 1.39A 1ho5B-5esvA:
undetectable		 1ho5B-5esvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5esv CH03 HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ASP A 100
GLY A 100
ASP A  56
THR A 100
 None
None
BMA  E 417 (-3.1A)
NAG  E 416 ( 4.7A)
 0.90A 1m4iA-5esvA:
undetectable		 1m4iA-5esvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 GLY E 118
CYH E 313
ASP E 211
ALA E 208
ALA E 205
 None
 1.10A 2br4A-5esvE:
undetectable		 2br4A-5esvE:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 GLY E 118
CYH E 313
ASP E 211
ALA E 208
ALA E 205
 None
 1.12A 2br4B-5esvE:
undetectable		 2br4B-5esvE:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5esv CH03 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.52A 3huoA-5esvA:
undetectable		 3huoA-5esvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 LEU E 285
PHE E 246
ILE E 213
LEU E 209
ASP E 237
 None
 1.17A 3ko0A-5esvE:
undetectable
3ko0B-5esvE:
undetectable
3ko0C-5esvE:
undetectable
3ko0D-5esvE:
undetectable		 3ko0A-5esvE:
20.39
3ko0B-5esvE:
20.39
3ko0C-5esvE:
20.39
3ko0D-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 ASP E 237
LEU E 285
PHE E 246
ILE E 213
LEU E 209
 None
 1.15A 3ko0G-5esvE:
undetectable
3ko0H-5esvE:
undetectable
3ko0I-5esvE:
undetectable
3ko0J-5esvE:
undetectable		 3ko0G-5esvE:
20.39
3ko0H-5esvE:
20.39
3ko0I-5esvE:
20.39
3ko0J-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 11 ASP E 237
LEU E 209
LEU E 285
PHE E 246
ILE E 213
 None
 1.15A 3ko0A-5esvE:
undetectable
3ko0B-5esvE:
undetectable
3ko0I-5esvE:
undetectable
3ko0J-5esvE:
undetectable		 3ko0A-5esvE:
20.39
3ko0B-5esvE:
20.39
3ko0I-5esvE:
20.39
3ko0J-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 LEU E 285
PHE E 246
ILE E 213
LEU E 209
ASP E 237
 None
 1.21A 3ko0K-5esvE:
undetectable
3ko0L-5esvE:
undetectable
3ko0S-5esvE:
undetectable
3ko0T-5esvE:
undetectable		 3ko0K-5esvE:
20.39
3ko0L-5esvE:
20.39
3ko0S-5esvE:
20.39
3ko0T-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 LEU E 209
LEU E 285
PHE E 246
ILE E 213
ASP E 237
 None
 1.20A 3ko0K-5esvE:
undetectable
3ko0L-5esvE:
undetectable
3ko0M-5esvE:
undetectable
3ko0N-5esvE:
undetectable		 3ko0K-5esvE:
20.39
3ko0L-5esvE:
20.39
3ko0M-5esvE:
20.39
3ko0N-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 ASP E 237
LEU E 209
LEU E 285
PHE E 246
ILE E 213
 None
 1.16A 3ko0M-5esvE:
undetectable
3ko0N-5esvE:
undetectable
3ko0O-5esvE:
undetectable
3ko0P-5esvE:
undetectable		 3ko0M-5esvE:
20.39
3ko0N-5esvE:
20.39
3ko0O-5esvE:
20.39
3ko0P-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		5 / 12 ILE E 222
GLY E 215
GLY E 220
ILE E 213
ALA E 245
 None
 0.99A 4kicB-5esvE:
undetectable		 4kicB-5esvE:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5esv CH03 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 GLY A  33
TYR A  32
GLY A  95
LEU A  34
LEU A   4
 None
 1.35A 5hwkA-5esvA:
undetectable		 5hwkA-5esvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5esv CH03 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 GLY A  33
TYR A  32
GLY A  95
LEU A  34
LEU A   4
 None
 1.35A 5hwkB-5esvA:
undetectable		 5hwkB-5esvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5esv CH03 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 207
THR A 205
VAL A 211
GLY A 118
VAL A 152
 None
 1.08A 6drzA-5esvA:
undetectable		 6drzA-5esvA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		4 / 6 GLY E 215
LEU E 219
VAL E 259
PHE E 246
 None
 0.90A 6h7lA-5esvE:
undetectable		 6h7lA-5esvE:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		4 / 6 GLY E 215
LEU E 219
VAL E 259
PHE E 246
 None
 0.91A 6h7lB-5esvE:
undetectable		 6h7lB-5esvE:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160
(Haemophilus
influenzae;
Human
immunodeficiency
virus
1) 		4 / 7 ASP E 237
ARG E 243
ASP E 284
GLU E 283
 None
 1.37A 6mn5E-5esvE:
undetectable		 6mn5E-5esvE:
17.22