SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5esx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		3 / 3 ASN A 144
ALA A 115
ASN A 119
 None
 0.74A 1n4fA-5esxA:
undetectable		 1n4fA-5esxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		5 / 8 VAL A 103
VAL A 104
LEU A  56
ILE A  46
CYH A  47
 None
 1.40A 3wzeA-5esxA:
undetectable		 3wzeA-5esxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 6 GLY A  84
TRP A  88
GLU A 120
ARG A  91
 None
 1.15A 4bqfA-5esxA:
undetectable		 4bqfA-5esxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 8 ARG A 173
ASP A 167
VAL A  48
ASP A 105
 None
5GP  A 600 (-4.4A)
None
5GP  A 600 (-3.7A)
 1.16A 4xqgB-5esxA:
2.1		 4xqgB-5esxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 6 PHE A 151
SER A  20
VAL A  23
ASP A  28
 None
 1.09A 5hesA-5esxA:
undetectable		 5hesA-5esxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 6 VAL A 156
MET A 166
ILE A 107
ASP A 109
 None
None
5GP  A 600 (-4.2A)
5GP  A 600 (-4.0A)
 1.15A 5iwuA-5esxA:
undetectable		 5iwuA-5esxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		3 / 3 LYS A  13
HIS A 185
HIS A 182
 None
 1.31A 5oexA-5esxA:
undetectable		 5oexA-5esxA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		3 / 3 LYS A  13
HIS A 185
HIS A 182
 None
 1.26A 5oexB-5esxA:
undetectable		 5oexB-5esxA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		3 / 3 LYS A  13
HIS A 185
HIS A 182
 None
 1.28A 5oexC-5esxA:
undetectable		 5oexC-5esxA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		3 / 3 LYS A  13
HIS A 185
HIS A 182
 None
 1.30A 5oexD-5esxA:
undetectable		 5oexD-5esxA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 5 VAL A 135
PRO A  55
GLY A 165
TYR A 164
 None
 1.10A 5x80A-5esxA:
undetectable
5x80B-5esxA:
undetectable		 5x80A-5esxA:
22.44
5x80B-5esxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 5 PRO A  55
GLY A 165
TYR A 164
VAL A 135
 None
 1.15A 5x80C-5esxA:
undetectable
5x80D-5esxA:
0.9		 5x80C-5esxA:
22.44
5x80D-5esxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		5 / 12 LEU A  60
HIS A  61
ARG A  62
ILE A  32
ASP A  28
 None
 1.28A 6bxnA-5esxA:
3.2		 6bxnA-5esxA:
20.36