SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5et1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 5 HIS A 184
GLU A 182
ALA A 212
HIS A 252
 None
GOL  C1301 ( 4.8A)
None
None
 1.12A 1errA-5et1A:
undetectable
1errB-5et1A:
undetectable		 1errA-5et1A:
21.49
1errB-5et1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 5 HIS A 184
GLU A 182
ALA A 213
HIS A 252
 None
GOL  C1301 ( 4.8A)
None
None
 1.29A 1errA-5et1A:
undetectable
1errB-5et1A:
undetectable		 1errA-5et1A:
21.49
1errB-5et1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5et1 ESPIN
(Mus
musculus) 		4 / 4 HIS A 317
ALA A 312
PHE A 314
GLY A 316
 None
 1.26A 1mj2B-5et1A:
undetectable		 1mj2B-5et1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5et1 ESPIN
(Mus
musculus) 		4 / 4 HIS A 317
ALA A 312
PHE A 314
GLY A 316
 None
 1.33A 1mj2D-5et1A:
undetectable		 1mj2D-5et1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 4 HIS A 317
ALA A 312
PHE A 314
GLY A 316
 None
 1.29A 1mjoB-5et1A:
undetectable		 1mjoB-5et1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 4 HIS A 317
ALA A 312
PHE A 314
GLY A 316
 None
 1.29A 1mjoA-5et1A:
undetectable		 1mjoA-5et1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 4 HIS A 317
ALA A 312
PHE A 314
GLY A 316
 None
 1.29A 1mjoD-5et1A:
undetectable		 1mjoD-5et1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5et1 ESPIN
(Mus
musculus) 		4 / 8 ALA A 243
ALA A 264
LEU A 225
VAL A 226
 None
 0.72A 2bxgA-5et1A:
undetectable		 2bxgA-5et1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5et1 ESPIN
(Mus
musculus) 		4 / 6 THR A 326
VAL A 327
LEU A 298
ALA A 309
 None
 1.07A 2e1qA-5et1A:
undetectable		 2e1qA-5et1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5et1 ESPIN
(Mus
musculus) 		4 / 6 THR A 326
VAL A 327
LEU A 298
ALA A 309
 None
 1.03A 2e1qC-5et1A:
undetectable		 2e1qC-5et1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5et1 ESPIN
MYOSIN-IIIB
(Mus
musculus) 		4 / 7 ALA A 105
ASP C1264
TYR C1268
HIS A  75
 None
 1.38A 2pncA-5et1A:
undetectable		 2pncA-5et1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5et1 ESPIN
MYOSIN-IIIB
(Mus
musculus) 		4 / 6 ALA A 105
ASP C1264
TYR C1268
HIS A  75
 None
 1.39A 2pncB-5et1A:
undetectable		 2pncB-5et1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5et1 ESPIN
MYOSIN-IIIB
(Mus
musculus) 		5 / 10 TYR C1267
TYR C1268
ALA A  78
ALA A  74
VAL A  40
 None
 1.26A 2wuzA-5et1C:
undetectable		 2wuzA-5et1C:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5et1 ESPIN
MYOSIN-IIIB
(Mus
musculus) 		5 / 10 TYR C1267
TYR C1268
ALA A  78
ALA A  74
VAL A  40
 None
 1.24A 2wuzB-5et1C:
undetectable		 2wuzB-5et1C:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5et1 ESPIN
(Mus
musculus) 		4 / 6 LEU A  90
GLY A  94
LEU A  86
SER A  84
 None
 0.89A 3aiaA-5et1A:
undetectable		 3aiaA-5et1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5et1 ESPIN
MYOSIN-IIIB
(Mus
musculus) 		4 / 7 ASP A  33
HIS A  42
TYR C1268
ASN A  69
 None
 0.94A 3avpA-5et1A:
undetectable		 3avpA-5et1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5et1 ESPIN
(Mus
musculus) 		5 / 12 LEU A 110
ALA A  74
LEU A  90
ALA A 111
THR A  72
 None
 1.03A 3dfrA-5et1A:
undetectable		 3dfrA-5et1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5et1 ESPIN
(Mus
musculus) 		5 / 12 LEU A  89
LEU A  90
LEU A  83
GLY A  47
LEU A  49
 None
 1.02A 3olsA-5et1A:
undetectable		 3olsA-5et1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5et1 ESPIN
(Mus
musculus) 		5 / 12 LEU A  89
LEU A  90
LEU A  83
GLY A  47
LEU A  49
 None
 1.08A 3q95B-5et1A:
undetectable		 3q95B-5et1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5et1 ESPIN
(Mus
musculus) 		4 / 7 THR A 326
VAL A 327
LEU A 298
ALA A 309
 None
 1.01A 3uniA-5et1A:
undetectable		 3uniA-5et1A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5et1 ESPIN
MYOSIN-IIIB
(Mus
musculus;
Mus
musculus) 		3 / 3 TYR C1267
HIS A  42
ARG A  45
 None
 1.00A 4htfA-5et1C:
undetectable		 4htfA-5et1C:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5et1 ESPIN
(Mus
musculus) 		3 / 3 ARG A 250
HIS A 252
SER A 249
 None
 0.94A 4mjwA-5et1A:
undetectable
4mjwB-5et1A:
undetectable		 4mjwA-5et1A:
20.87
4mjwB-5et1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5et1 ESPIN
(Mus
musculus) 		3 / 3 SER A 249
ARG A 250
HIS A 252
 None
 0.94A 4mjwA-5et1A:
undetectable
4mjwB-5et1A:
undetectable		 4mjwA-5et1A:
20.87
4mjwB-5et1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5et1 ESPIN
(Mus
musculus) 		5 / 12 LEU A  89
LEU A  90
LEU A  83
GLY A  47
LEU A  49
 None
 1.02A 4pxmA-5et1A:
undetectable		 4pxmA-5et1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 6 LEU A   3
LEU A  18
LEU A  21
HIS A  42
 None
 0.96A 5gs4A-5et1A:
undetectable		 5gs4A-5et1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5et1 ESPIN
(Mus
musculus) 		4 / 6 LEU A   7
LEU A  18
LEU A  21
LEU A  61
 None
 0.95A 5gs4A-5et1A:
undetectable		 5gs4A-5et1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5et1 ESPIN
(Mus
musculus) 		5 / 12 VAL A 107
LEU A 108
ALA A 132
GLY A 127
LEU A  90
 None
None
GOL  A 401 (-3.7A)
GOL  A 402 ( 4.4A)
None
 0.99A 5kirA-5et1A:
undetectable		 5kirA-5et1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5et1 ESPIN
(Mus
musculus) 		5 / 12 VAL A  64
SER A  65
THR A  72
ALA A  74
VAL A  56
 None
 1.36A 6drxA-5et1A:
undetectable		 6drxA-5et1A:
21.82